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Researchers use metal-free catalyst to synthesize ketone from aldehyde

Ketones are important organic compounds found in a variety of pharmaceuticals, agrochemicals, and natural products.

4 Apr 2019

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

Human immunodeficiency virus, or HIV, attacks the immune system, making affected individuals more susceptible to infections. When patients with HIV are treated with antiretroviral therapy, their immune system can recover, but some of them produce self-destructive proteins, or autoantibodies.

2 Apr 2019

Young scientists develop cheap and simple catalyst system for organic synthesis

The removal of carboxyl groups and the release of alkyl radical fragments from the tight binding of carboxyl groups are one of the most interesting and promising directions in organic synthesis, especially in the field of new drug synthesis.

30 Mar 2019

C-Path and Japan's PMDA join forces on first-of-its-kind biomarker project

Critical Path Institute announced today that a formal consultation between its Predictive Safety Testing Consortium and Japan's Pharmaceuticals and Medical Devices Agency has resulted in an agreement on a first-of-its-kind approach to compare the levels of eight novel urinary kidney safety biomarkers in healthy Japanese volunteers to data collected on these same biomarkers in healthy Western volunteers in a bridging study.

27 Mar 2019

Researchers identify a more effective treatment for cancer

Researchers from Mount Sinai and IBM have discovered a novel clue in explaining how cancer cells with identical genomes can respond differently to the same therapy.

22 Mar 2019

Johns Hopkins study sheds light on resistance to radiation treatment

A new Johns Hopkins study offers promise towards someday being able to non-invasively examine changes in cancerous tumors to determine whether they'll respond to radiation treatment, before treatment even begins.

1 Mar 2019

New green, economical way achieves key organic synthesis via catalyst synergy

In organic chemistry, discovering new reactions is one thing, but to carry them off efficiently is quite another. Carbon-carbon bond-forming is at the heart of organic synthesis, allowing us to stitch together diverse functional groups into an endless array of useful compounds.

26 Feb 2019

HENA describes new approach to promoting health equity through intersectoral partnerships

Recognizing the persistence of health inequities in the Americas, an emerging Health Equity Network of the Americas describes its approach to promoting health equity through intersectoral partnerships in a newly released issue of Ethnicity & Disease.

23 Feb 2019

Using light-based method for production of pharmaceutical molecules

Photoelectrochemical cells are widely studied for the conversion of solar energy into chemical fuels. They use photocathodes and photoanodes to "split" water into hydrogen and oxygen respectively.

18 Feb 2019

Experts offer five solutions to achieve gender equality in medicine and science

Women's representation in science and medicine has slowly increased over the past few decades. However, this rise in numbers of women, or gender diversity, has not been matched by a rise in gender inclusion.

11 Feb 2019

Targeting aging process itself can lead to better and more effective interventions

Medical care for older adults has long focused on preventing and treating chronic diseases and the conditions that come with them.

11 Feb 2019

New solutions needed to improve care and reduce cost of high-need, high-cost patients

By many estimates, only 5% of U.S. patients are high-need, high-cost, yet they account for about 50% of health care spending.

7 Feb 2019

Researcher explore why some patients recover quickly after surgery while others don't

Why do some patients recover quickly after surgery, while others don't? That is an important question when treating older frail patients suffering from aortic stenosis. Lead author Dae Hyun Kim, M.D., M.P.H., Sc.D., and principle investigator Director Lewis A. Lipsitz in the Marcus Institute for Aging Research at Hebrew SeniorLife explore this question in a paper published today in the Journal of the American Medical Association Internal Medicine.

5 Feb 2019

Gerontologists assess change in patients' functional status after valve replacement procedure

Affecting an estimated one in eight people older than 75, aortic valve stenosis - a narrowing of the heart's main artery - makes the heart work harder to supply the body with blood, potentially limiting patient's activity levels an quality of life. Ultimately, aortic stenosis can lead to stroke, arrhythmia, heart failure and death.

5 Feb 2019

Researchers call for industry standards to help improve high-throughput genomic sequencing

Researchers from the George Washington University, the U.S. Food and Drug Administration, and industry leaders published in PLOS Biology, describing a standardized communication method for researchers performing high-throughput sequencing called BioCompute.

31 Jan 2019

Gender-specific smoking cessation strategies may improve quit outcomes in women

Gender matters when it comes to smoking cessation. Women are 31 percent less likely to quit smoking successfully, according to the National Institute of Drug Abuse, in part because nicotine replacement therapy is thought to be more effective in male smokers.

25 Jan 2019

Free screening for lung cancer can save money while building healthy relationship with patients

A free, simple screening for lung cancer can save a patient money, while building a healthy relationship for any medical needs they may have in the future.

24 Jan 2019

UTSA researchers reveal important insight into cocaine addiction

Researchers at The University of Texas at San Antonio have revealed significant insight into cocaine addiction, a phenomenon which has grown significantly in the United States since 2015.

10 Jan 2019

Drug development options diversified with new manganese catalyst

A University of Illinois team of researchers led by chemistry professor M. Christina White has developed a new manganese-based catalyst that can change the structure of druglike molecules to make new drugs, advancing the pace and efficiency of drug development.

9 Jan 2019

Scientists develop new resource-saving green alternative for drug production

For the production of drugs, pesticides and smartphone displays, most of the processes are cost-intensive and generate a large amount of waste. Scientists at the University of Göttingen have now succeeded in developing a resource-saving "green" alternative. The results were published in Nature Catalysis.

8 Jan 2019