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New lab technique could spark a 'paradigm shift' in testing protein-based drugs

New Jersey Institute of Technology researchers have unveiled a new lab technique they say represents a "paradigm shift" in how pharmaceutical laboratories test and produce new protein-based drugs, such as therapeutic monoclonal antibodies being developed to treat a variety of diseases, from cancers to infectious diseases.

27 Sep 2022

Singapore researchers identify protein that transports degraded membrane lipids out of lysosomes

Researchers at Duke-NUS Medical School and colleagues in Singapore have identified a protein that transports degraded membrane lipids out of lysosomes, cellular organelles that are the breakdown factories of cells.

27 Sep 2022

Mutation in newly discovered small protein linked to increase in Alzheimer's disease risk

A mutation in a newly discovered small protein is connected to a significant increase in the risk for Alzheimer's disease, expanding the known gene targets for the disease and presenting a new potential avenue for treatment, according to a new USC study.

21 Sep 2022

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

Autophagy is a self-degradation process that cells use to remove unneeded or damaged components. There are several forms of autophagy, including macroautophagy, which is a bulk degradation system used to target materials in the cell's cytosol to organelles called lysosomes for enzymatic breakdown.

20 Sep 2022

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

Researchers explored the effect of SARS-CoV-2 exposure on the brain.

20 Sep 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022

First Hand Experience in the Field of Clinical and Applied Mass Spectrometry

This Interview focuses on describing the Clinical and Applied Mass Spectrometry Program available at LOYOLA UNIVERSITY CHICAGO

From Loyola University Chicago Health Sciences Campus 16 Sep 2022

SARS-CoV-2 N escape mutations do not affect rapid antigen testing

A new study maps the escape mutations found in various strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could cause them to escape neutralization by antibodies or detection by rapid antigen tests that rely on antibody binding for a positive result.

16 Sep 2022

Spectrometry News and Research

New lab technique could spark a 'paradigm shift' in testing protein-based drugs

Singapore researchers identify protein that transports degraded membrane lipids out of lysosomes

Mutation in newly discovered small protein linked to increase in Alzheimer's disease risk

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

First Hand Experience in the Field of Clinical and Applied Mass Spectrometry

SARS-CoV-2 N escape mutations do not affect rapid antigen testing

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

Interactions between SIRT5 and SARS-CoV-2 Nsp14 protein

What is the impact of COVID-19 treatments targeting intracellular Neu1?

Role of the transketolase-like 1 gene in the development of the modern human brain

Many neurocognitive benefits conferred on children born to mothers who eat fish

Photocatalyst-based ViraMap platform maps SARS-CoV-2 spike protein interactions on the cell surface

Exposure to blue light may accelerate aging

Temporo-spatial pharmacometabolomics method to evaluate microregional effect of OLZ on brain tissue

Respiratory diseases affect females and males differently, study says

New labeling technique helps analyze the contents of exosomes from cells

Exploration of glycan shield structure of sarbecoviruses provides new insights into developing pan-coronavirus vaccines

Study identifies novel neutrophil biomarkers of delayed recovery in COVID-19

Enhancing confidence in chemical ionization spectrometry data eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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