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Researchers identify eight new active molecules against Alzheimer

Researchers of the Unit of Medicine Design and Molecular Topology (Department of Physics Chemistry) of the University of Valencia have discovered eight new active molecules against Alzheimer by a novel mechanism of action, different to the currently used medicines. The work has just been published in the "Plos One" magazine.

11 Apr 2014

Crescendo raises additional £2M ($3.3M) in final close of Series A financing from EMBL Ventures

Crescendo Biologics Limited today announces it has raised a further £2m ($3.3m), from EMBL Ventures, in a final close of its Series A financing. Originally announced in December 2013, the Series A now totals £19.5m. It was led by Imperial Innovations and included new investor Astellas Venture Management. Founding seed investor Sofinnova Partners also contributed significantly to the round.

3 Apr 2014

Scientists present protein that facilitates control of nerve cells by light

Networked nerve cells are the control center of organisms. In a nematode, 300 nerve cells are sufficient to initiate complex behavior. To understand the properties of the networks, re-searchers switch cells on and off with light and observe the resulting behavior of the organism.

2 Apr 2014

Cambridge Business Innovation Award for Crescendo Biologics

Crescendo Biologics Limited (Crescendo) today announces it has been awarded the prize for Business Innovation at the Cambridge News Business Excellence Awards 2014.

28 Mar 2014

Tumor suppressor gene linked to stem cell function

Just as archeologists try to decipher ancient tablets to discern their meaning, UT Southwestern Medical Center cancer biologists are working to decode the purpose of an ancient gene considered one of the most important in cancer research.

27 Mar 2014

Study: Dab2 can exhibit neuroprotective effects in Alzheimer's by regulating TGF-β1/SMAD signaling

Transforming growth factor-beta (TGF-β) type II receptor (TβRII) levels are extremely low in the brain tissue of patients with Alzheimer's disease.

27 Mar 2014

Researchers create new line of human embryonic stem cells

Researchers at the University of Washington have successfully created a line of human embryonic stem cells that have the ability to develop into a far broader range of tissues than most existing cell lines.

18 Mar 2014

People who experience chronic sleep disturbance could face earlier onset of dementia, Alzheimer's

People who experience chronic sleep disturbance—either through their work, insomnia or other reasons—could face an earlier onset of dementia and Alzheimer's, according to a new pre-clinical study by researchers at Temple University.

18 Mar 2014

Researchers examine role of alpha-synuclein in neuronal cells

Alpha-synuclein is a principal component of Lewy bodies and Lewy neurites, which are pathologic hall-marks of Parkinson's disease. Alpha-synuclein is generally considered to play a role in synaptic activity, although its function remains largely unknown.

13 Mar 2014

Removing gut bacteria may play critical role in reducing cancer risk

Bacteria in the gut are essential for the development of intestinal tumors in mice, according to research led by investigators from the Icahn School of Medicine at Mount Sinai. Removing the bacteria may play a critical role in reducing cancer risk, the researchers write, in the March issue of the Journal of Experimental Medicine.

5 Mar 2014

Neuroscientists unlock a piece of puzzle in fight against Lou Gehrig's disease

Keck School of Medicine of USC neuroscientists have unlocked a piece of the puzzle in the fight against Lou Gehrig's disease, a debilitating neurological disorder that robs people of their motor skills.

4 Mar 2014

CUMC researchers find potential target for treating autism, schizophrenia, and other brain disorders

Columbia University Medical Center (CUMC) researchers have determined that a small region of the hippocampus known as CA2 is essential for social memory, the ability of an animal to recognize another of the same species.

24 Feb 2014

NCKU research team identifies medicine capable of rejuvenating aged hearts

A southern Taiwan-based National Cheng Kung University (NCKU) research team has identified the critical time period and a drug as treatment for cardiac repairing, the university revealed recently at a press conference.

14 Feb 2014

Researchers develop new model for isolating effects of nutrients on gene expression, physiology

Everyday our cells take in nutrients from food and convert them into the building blocks that make life possible. However, it has been challenging to pinpoint exactly how a single nutrient or vitamin changes gene expression and physiology.

14 Feb 2014

New book encourages critical thinking and effective action for future of global agrifood system

Carbon dioxide emissions from transportation, energy generation and built infrastructure may be major contributors to climate change, but they may not be the biggest ones. According to UC Santa Barbara environmental science professor David A. Cleveland, that dubious distinction could go to the agrifood system.

6 Feb 2014

Study focuses on development and spread of Alzheimer's disease throughout the brain

The development of Alzheimer's disease and the way it spreads throughout the brain will be the focus of a pioneering study conducted at Aston University (UK).

4 Feb 2014

Research: SSeCKS/AKAP12 gene key inhibitor of prostate cancer metastasis

New evidence reported by researchers at Roswell Park Cancer Institute (RPCI) lends support to the hypothesis that the SSeCKS/AKAP12 gene is a key inhibitor of prostate cancer metastasis.

4 Feb 2014

Drugs that modify DNA structure may be beneficial for treating Alzheimer's disease

In a study published this week in Nature Neuroscience, Bess Frost, PhD, and co-authors, identify abnormal expression of genes, resulting from DNA relaxation, that can be detected in the brain and blood of Alzheimer's patients.

31 Jan 2014

Researchers identify potential genes that can be targeted for new treatments for hepatocellular cancer

Patients with advanced hepatocellular (or liver) cancer have high mortality rates, with existing drugs demonstrating only a small, but significant survival advantage. By combining a zebrafish model of liver cancer with data from human tumors, researchers from the Icahn School of Medicine at Mount Sinai hope to identify potential genes of interest that can be targeted for new treatments for hepatocellular carcinoma, the most common form of liver cancer to develop from liver cells.