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EMA grants PRIME designation to Themis' chikungunya vaccine candidate

Themis announced today that the European Medicines Agency has granted PRIority MEdicines designation to its most advanced program in development, a vaccine to prevent chikungunya fever.

11 Jun 2018

Two-drug combination provides more reliable, effective care for women suffering miscarriage

A combination of the drugs mifepristone and misoprostol can help bring closure to some women and their families suffering from miscarriage, and reduces the need for surgical intervention to complete the painful miscarriage process.

7 Jun 2018

Study finds factors that help or hinder patient involvement in clinical trials of mitochondrial disease

As clinical trials gear up with the aim of attaining the first FDA-approved treatments for mitochondrial disease, a new study reports for the first time what patients and families say would motivate them for or against participating in such research trials.

7 Jun 2018

Microbiotica collaborates with Genentech to develop drugs for IBD

Microbiotica, a leading player in microbiome-based therapeutics spun out of the Wellcome Sanger Institute, today announced that it has entered into a multi-year strategic collaboration with Genentech, a member of the Roche Group, to discover, develop and commercialize biomarkers, targets and medicines for inflammatory bowel disease.

6 Jun 2018

Classifying heart failure patients based on redox status may help personalize treatment

For more than six decades, oxidative stress has been linked to heart failure, a progressive weakening of the heart muscle that can lead to death. While antioxidant supplements such as vitamin C, vitamin B and beta-carotene have been widely used in heart failure, they often prove ineffective.

6 Jun 2018

Cedars-Sinai study identifies gut gas associated with diarrhea

Cedars-Sinai investigators have for the first time identified a gas produced in gut that could improve the diagnosis and treatment of patients with two common intestinal illnesses - small intestine bacterial overgrowth and irritable bowel syndrome.

6 Jun 2018

Disintegrating brain lesions could predict disease progression in MS patients

For decades, clinicians treating multiple sclerosis have interpreted the appearance of new or expanding brain lesions on magnetic resonance imaging scans as a sign that a patient's disease is getting worse.

5 Jun 2018

MiNA Therapeutics announces initial results from phase I trial of saRNA candidate in liver cancer patients

MiNA Therapeutics, the pioneer in RNA activation therapeutics, today announced preliminary results from its ongoing Phase I study of small activating RNA candidate MTL-CEBPA in advanced liver cancer.

4 Jun 2018

Phase I trial shows safety of investigational drug in treating chronic lymphocytic leukemia

Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the "stemness" of chronic leukemia cancer cells - their ability to self-renew and resist terminal differentiation and senescence.

1 Jun 2018

Research finds keyhole surgery to be more effective than physiotherapy for groin pain

As the FIFA World Cup approaches researchers have found that keyhole surgery could help get injured footballers back on the pitch faster than physiotherapy-led treatments.

1 Jun 2018

Opdivo plus low-dose Yervoy shows promising results in treating renal cell carcinoma patients

Bristol-Myers Squibb Company today announced patient-reported outcomes data from the Phase 3 CheckMate -214 trial in intermediate- and poor-risk patients with advanced renal cell carcinoma treated with the Immuno-Oncology combination Opdivo plus low-dose Yervoy versus sunitinib over a two-year follow-up period.

1 Jun 2018

Research project offers hope for pediatric patients with thalassemia

Children born with thalassaemia, a genetic blood disease, cannot create normal haemoglobin, which is needed to produce healthy red blood cells. Regular blood transfusions are the only treatment available, but iron overload is inevitable.

1 Jun 2018

Agendia and Angsana partner to market MammaPrint, BluePrint breast cancer tests in Southeast Asia

Agendia, Inc., a world leader in personalized medicine and molecular cancer diagnostics, and Angsana Molecular & Diagnostics Laboratory Pte Ltd, a subsidiary of Parkway Pantai, announce a partnership to market the MammaPrint Breast Cancer Risk of Recurrence test and the BluePrint Molecular Subtyping test to physicians across Southeast Asia, including Singapore, Malaysia, Vietnam, Brunei and Myanmar.

31 May 2018

FDA approves first stand-alone prosthetic iris in the U.S.

The U.S. Food and Drug Administration today approved the first stand-alone prosthetic iris in the United States, a surgically implanted device to treat adults and children whose iris (the colored part of the eye around the pupil) is completely missing or damaged due to a congenital condition called aniridia or other damage to the eye.

30 May 2018

New trial to test if omega-3 capsules can stop secondary liver cancer recurrence after surgery

A new clinical trial from the University of Leeds is testing omega-3 capsules in patients who have bowel cancer which has spread to the liver, to see if it can stop the cancer returning after surgery.

30 May 2018

New studies focus on vitamin D supplementation in pregnancy, for infants, children

Vitamin D supplementation in pregnancy and for infants and children is the focus of two studies, an editorial and a patient page.

30 May 2018

Fewer women meet eligibility criteria for clinical trial of heart failure drugs, study finds

Clinical trial enrolment favors men, according to a study presented today at Heart Failure 2018 and the World Congress on Acute Heart Failure, a European Society of Cardiology congress. The study found that fewer women meet eligibility criteria for trials of heart failure medication.

28 May 2018

Causes and treatment of acute heart failure vary by region, registry shows

Triggers of acute heart failure vary globally, according to late breaking results from the REPORT-HF registry presented today at Heart Failure 2018 and the World Congress on Acute Heart Failure, a European Society of Cardiology Congress.

26 May 2018

Delivery of standardized diabetes care could help achieve equitable health outcomes for all patients

Although kidney problems related to type 2 diabetes disproportionately affect blacks, when black and white individuals received comparable diabetes care within the context of a clinical trial, black race was not associated with faster development or progression of chronic kidney disease.

25 May 2018

Researchers find novel ways to improve participation in clinical research

Videos and creative uses of other visuals provide a novel way to obtain informed consent during clinical trials to improve participants' understanding and retention of trial information, according to a study by Nemours Children's Health System presented at the American Thoracic Society (ATS) Annual Conference.

25 May 2018

Clinical Trial News and Research

EMA grants PRIME designation to Themis' chikungunya vaccine candidate

Two-drug combination provides more reliable, effective care for women suffering miscarriage

Study finds factors that help or hinder patient involvement in clinical trials of mitochondrial disease

Microbiotica collaborates with Genentech to develop drugs for IBD

Classifying heart failure patients based on redox status may help personalize treatment

Cedars-Sinai study identifies gut gas associated with diarrhea

Disintegrating brain lesions could predict disease progression in MS patients

MiNA Therapeutics announces initial results from phase I trial of saRNA candidate in liver cancer patients

Phase I trial shows safety of investigational drug in treating chronic lymphocytic leukemia

Research finds keyhole surgery to be more effective than physiotherapy for groin pain

Opdivo plus low-dose Yervoy shows promising results in treating renal cell carcinoma patients

Research project offers hope for pediatric patients with thalassemia

Agendia and Angsana partner to market MammaPrint, BluePrint breast cancer tests in Southeast Asia

FDA approves first stand-alone prosthetic iris in the U.S.

New trial to test if omega-3 capsules can stop secondary liver cancer recurrence after surgery

New studies focus on vitamin D supplementation in pregnancy, for infants, children

Fewer women meet eligibility criteria for clinical trial of heart failure drugs, study finds

Causes and treatment of acute heart failure vary by region, registry shows

Delivery of standardized diabetes care could help achieve equitable health outcomes for all patients

Researchers find novel ways to improve participation in clinical research

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