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Influenza A virus suppresses SARS-CoV-2 replication during co-infection

SARS-CoV-2 does not suppress the replication of influenza A in simultaneous or sequential co-infections.

13 Feb 2023

Neuroprotectant linked to reduced death and disability among stroke patients

The neuroprotectant ApTOLL, a medication that may shield the brain from tissue damage, was linked to reduced death and disability among people being treated for stroke when used with standard treatments to restore blood flow, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2023.

13 Feb 2023

Using blood pressure medications after endovascular treatment for stroke may not be safe or effective

Using blood pressure medications to lower the top number of blood pressure reading (systolic blood pressure) may not be safe or effective among people who have an acute ischemic stroke and undergo a successful mechanical clot removal — endovascular therapy, according to a phase-2 late-breaking clinical trial presented today at the American Stroke Association's International Stroke Conference 2023.

13 Feb 2023

OHSU researchers confirm first-ever nonhuman primate model of Usher syndrome

Those with Usher Syndrome -- the leading hereditary cause for simultaneous deafness and blindness, for which there is no treatment -- may have a new reason for hope now that researchers have confirmed the first-ever nonhuman primate model of their disease.

13 Feb 2023

Paxlovid can prevent hospitalization and death for patients infected with Omicron variants, study shows

Though many Coloradans are proceeding as though the COVID-19 pandemic is over, the virus continues to circulate, evolve and have an impact - especially for older adults and those with underlying medical conditions.

13 Feb 2023

Scientists illuminate the mechanisms that prevent p53 activation from triggering cancer cell death

Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes.

13 Feb 2023

Researchers report a physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel

Researchers developed spherical hydrogel inhalation for enhanced lung defense to protect against SARS-CoV-2 infections.

13 Feb 2023

Long-term caloric restriction has a small effect on the DNA methylation measure of the pace of aging

Researchers assessed the impact of caloric restriction on biological aging among the comprehensive assessment of the long-term effects of reducing the intake of energy (CALERIE) randomized controlled trial participants.

13 Feb 2023

Declining PSA levels predict improved survival rates in men with non-metastatic castration-resistant prostate cancer

Declines in prostate-specific antigen (PSA) level after treatment with the next-generation androgen receptor inhibitor drug enzalutamide predict improved survival rates in men with non-metastatic castration-resistant prostate cancer (nmCRPC), reports The Journal of Urology, an Official Journal of the American Urological Association.

10 Feb 2023

Pathological significance of CEACAMS 1, 5, and 6 in cancer biology, immunology and inflammatory disease

A new review was published in Genes & Cancer on February 1, 2023, entitled, "CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens."

10 Feb 2023

Study identifies a previously unknown role of 'natural killer' immune cells

Melbourne researchers have improved our understanding of how the immune system is regulated to prevent disease, identifying a previously unknown role of 'natural killer' (NK) immune cells.

10 Feb 2023

A cost-effective approach for improving children's oral health through school-based care

In a study of nearly 3,000 schoolchildren, silver diamine fluoride - a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening - was as effective against cavities as dental sealants, the standard of care.

10 Feb 2023

Personalizing CAR-T cell stimulation during manufacturing can enhance its functionality

New adoptive T cell therapies - in which T cells, the immune system's natural hunters patrolling the body for foreign adversaries, are retrieved from cancer-riddled patients, super-charged and amplified outside the body, and then infused back into the same patient - are changing the prospects of cancer patients.

10 Feb 2023

Researchers gain new insights into the development of drug-resistant mutant lineages of cells

A deeper understanding of how tumor cells respond to treatment is vital to improving the effectiveness of therapies for diseases such as cancer.

10 Feb 2023

Pegylated interferon lambda shows good efficacy against COVID-19

In a recent study published in The New England Journal of Medicine, researchers used the TOGETHER platform trial protocol to perform a phase III randomized controlled trial (RCT) to evaluate the effectiveness of pegylated interferon (IFN) lambda (λ) therapy in outpatients with coronavirus disease 2019 (COVID-19) in Canada and Brazil.

9 Feb 2023

Can carbohydrate be reduced too low for weight loss, and glycemic control?

A new review in the Journal of Clinical Lipidology aimed to describe the definitions of carbohydrate-restricted dietary patterns, the potential benefits related to cardiometabolic risk factors, and whether healthcare professionals should consider it for glycemic management and weight loss.

9 Feb 2023

New milestones for the treatment of hemophilia

Hemophilia A is the most common severe form of hemophilia. It affects almost exclusively the male sex. The disease can usually be treated well, but the medicines known so far do not help all of those affected.

9 Feb 2023

FDA approves first drug for ESR1-mutated breast cancer

Dr. Rajkumar Lakshmanaswamy, Ph.D., Chair of the Department of Molecular and Translational Medicine, Center of Emphasis in Cancer and Dean of the L. Frederick Francis Graduate School of Biomedical Sciences at Texas Tech University Health Sciences Center El Paso is available to speak on the Federal Drug Administration's approval of the selective estrogen receptor (ER) degrader elacestrant (Orserdu).

9 Feb 2023

New strategies to beat rare tumors of the adrenal gland

Only one in 100,000 people suffer from a pheochromocytoma, a tumor of the adrenal gland. If the tumor has already metastasized, a radioactive compound can be used to detect malignant cells that have spread to other parts of the body, and to irradiate them from the inside.

9 Feb 2023

Four teams supported by SU2C focus on increasing diversity in early phase cancer clinical trials

Stand Up To Cancer today announced four teams focused on increasing diversity in early phase cancer clinical trials.

8 Feb 2023

Therapy News and Research

Influenza A virus suppresses SARS-CoV-2 replication during co-infection

Neuroprotectant linked to reduced death and disability among stroke patients

Using blood pressure medications after endovascular treatment for stroke may not be safe or effective

OHSU researchers confirm first-ever nonhuman primate model of Usher syndrome

Paxlovid can prevent hospitalization and death for patients infected with Omicron variants, study shows

Scientists illuminate the mechanisms that prevent p53 activation from triggering cancer cell death

Researchers report a physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel

Long-term caloric restriction has a small effect on the DNA methylation measure of the pace of aging

Declining PSA levels predict improved survival rates in men with non-metastatic castration-resistant prostate cancer

Pathological significance of CEACAMS 1, 5, and 6 in cancer biology, immunology and inflammatory disease

Study identifies a previously unknown role of 'natural killer' immune cells

A cost-effective approach for improving children's oral health through school-based care

Personalizing CAR-T cell stimulation during manufacturing can enhance its functionality

Researchers gain new insights into the development of drug-resistant mutant lineages of cells

Pegylated interferon lambda shows good efficacy against COVID-19

Can carbohydrate be reduced too low for weight loss, and glycemic control?

New milestones for the treatment of hemophilia

FDA approves first drug for ESR1-mutated breast cancer

New strategies to beat rare tumors of the adrenal gland

Four teams supported by SU2C focus on increasing diversity in early phase cancer clinical trials

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