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New insights into how obesity, type 2 diabetes can create stress response in the brain

Joslin researchers have gained new insights into how obesity and type 2 diabetes can create a stress response in the brain, especially in the hypothalamus (the brain region that regulates appetite and energy production), that may contribute to altering metabolism throughout the body. The findings are reported in the October issue of the Journal of Clinical Investigation.

2 Oct 2013

Mutant protein blocks HIV infection and transmission, scientists find

A mutant of an immune cell protein called ADAP (adhesion and degranulation-promoting adaptor protein) is able to block infection by HIV-1 (human immunodeficiency virus 1), new University of Cambridge research reveals. The researchers, who were funded by the Wellcome Trust, believe that their discovery will lead to new ways of combatting HIV.

2 Oct 2013

Women of Mexican descent more likely to be diagnosed with aggressive form of breast cancer

Scientific data suggest that a woman reduces her risk of breast cancer by breastfeeding, having multiple children and giving birth at a younger age. A study led by the University of California, San Diego School of Medicine and recently published online by Cancer Epidemiology, Biomarkers & Prevention, indicates that women of Mexican descent may not fit that profile. In fact, results suggest that women of Mexican descent with more children and those who breastfeed are more likely to be diagnosed with an aggressive form of breast cancer.

2 Oct 2013

Final patient completion of phase II study of TR040303 in patients treated for acute myocardial infarction announced by Trophos

Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics from discovery to clinical validation for indications with under-served needs in neurology and cardiology, announces today the final patient completion of a phase II study of TR040303 in patients treated for acute myocardial infarction (MI). Outcome data of this study is expected to be available towards the end of 2013.

2 Oct 2013

Precise value of EXACT in COPD uncertain

EXACT is effective in assessing exacerbations of chronic obstructive pulmonary disease in the outpatient setting, a study shows.

1 Oct 2013

WATCH: The Novex Bolt Orchestra

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1 Oct 2013

Researchers identify new prospects for developing cancer therapies

By detailing a process required for repairing DNA breakage, scientists at the Duke Cancer Institute have gained a better understanding of how cells deal with the barrage of damage that can contribute to cancer and other diseases.

1 Oct 2013

Research findings show how flawed transport gene contributes to autism

Researchers say it's clear that some cases of autism are hereditary, but have struggled to draw direct links between the condition and particular genes. Now a team at the Johns Hopkins University School of Medicine, Tel Aviv University and Technion-Israel Institute of Technology has devised a process for connecting a suspect gene to its function in autism.

1 Oct 2013

Sun Pharma, Intrexon Team Up To Target Ocular Diseases

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1 Oct 2013

Discovery paves way for new therapeutic strategies to protect heart health of diabetes patients

UC Davis Health System researchers have identified for the first time a biological pathway that is activated when blood sugar levels are abnormally high and causes irregular heartbeats, a condition known as cardiac arrhythmia that is linked with heart failure and sudden cardiac death.

1 Oct 2013

Pitt scientists open door to potential research into cures for Parkinson's disease

A mix of serendipity and dogged laboratory work allowed a diverse team of University of Pittsburgh scientists to report in the Oct. 1 issue of Nature Cell Biology that they had solved the mystery of a basic biological function essential to cellular health.

1 Oct 2013

UCSB study demonstrates new tool to resolve structure of membrane proteins

Membrane proteins are responsible for transporting chemicals and messages between a cell and its environment. But determining their structure has proved challenging for scientists. A study by UC Santa Barbara's Han Research Group demonstrates a new tool to resolve the structure of membrane-embedded and membrane-associating proteins using the water dynamics gradient they found across and above the lipid bilayer as a unique ruler.

1 Oct 2013

Sun Pharma, Intrexon partner to develop controllable gene-based therapies for ocular diseases

Sun Pharmaceutical Industries Ltd., an international specialty pharmaceutical company focused on chronic diseases, through its subsidiary, and Intrexon Corporation, a leader in synthetic biology, today announced the formation of a joint venture to develop controllable gene-based therapies for the treatment of ocular diseases that cause partial or total blindness in millions of people worldwide.

1 Oct 2013

Research reveals significant role of Axl receptor in progression, therapeutic resistance of AML

BerGenBio AS, an oncology biopharmaceutical company, announces that a paper entitled "Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine cross-talk of leukemia cells with bone marrow stroma" by Ben-Batalla et al., has been published in Blood, the most cited peer-reviewed research journal in the field of hematology.

1 Oct 2013

Standoff between a mutated gene and normal counterpart keeps certain cancer cells alive

What keeps leukemia cells alive almost forever, able to continue dividing endlessly and aggressively? New research at the Weizmann Institute suggests that, in around a quarter of all leukemias, the cancer cells rely on an internal "balance of terror" to keep going.

1 Oct 2013

Insulin interaction map could lead to new therapeutic targets for type 2 diabetes

A team led by scientists at The Scripps Research Institute has created the first comprehensive roadmap of the protein interactions that enable cells in the pancreas to produce, store and secrete the hormone insulin. The finding makes possible a deeper scientific understanding of the insulin secretion process—and how it fails in insulin disorders such as type 2 diabetes.

1 Oct 2013

FDA grants accelerated approval to Perjeta for neoadjuvant treatment of breast cancer

The U.S. Food and Drug Administration today granted accelerated approval to Perjeta (pertuzumab) as part of a complete treatment regimen for patients with early stage breast cancer before surgery (neoadjuvant setting). Perjeta is the first FDA-approved drug for the neoadjuvant treatment of breast cancer.

1 Oct 2013

Researchers discover how aspirin improves survival in patients diagnosed with colon cancer

Researchers believe they have discovered how aspirin improves survival in patients diagnosed with colon cancer, the 2013 European Cancer Congress (ECC2013) heard today.

1 Oct 2013

Shortage of zinc may contribute to diseases like Alzheimer's and Parkinson's

Scientists at the University of Wisconsin-Madison have made a discovery that, if replicated in humans, suggests a shortage of zinc may contribute to diseases like Alzheimer's and Parkinson's, which have been linked to defective proteins clumping together in the brain.

1 Oct 2013

Researchers show that men experience more harm than good from routine PSA screening

Prostate cancer screening using the prostate-specific antigen (PSA) test is widely used in France despite a lack of evidence showing that it reduces cancer deaths. Now, researchers have shown that men experience more harm than good from routine PSA screening, according to research to be presented on Monday by Professor Mathieu Boniol, at the 2013 European Cancer Congress (ECC2013).

1 Oct 2013

G Protein News and Research

New insights into how obesity, type 2 diabetes can create stress response in the brain

Mutant protein blocks HIV infection and transmission, scientists find

Women of Mexican descent more likely to be diagnosed with aggressive form of breast cancer

Final patient completion of phase II study of TR040303 in patients treated for acute myocardial infarction announced by Trophos

Precise value of EXACT in COPD uncertain

WATCH: The Novex Bolt Orchestra

Researchers identify new prospects for developing cancer therapies

Research findings show how flawed transport gene contributes to autism

Sun Pharma, Intrexon Team Up To Target Ocular Diseases

Discovery paves way for new therapeutic strategies to protect heart health of diabetes patients

Pitt scientists open door to potential research into cures for Parkinson's disease

UCSB study demonstrates new tool to resolve structure of membrane proteins

Sun Pharma, Intrexon partner to develop controllable gene-based therapies for ocular diseases

Research reveals significant role of Axl receptor in progression, therapeutic resistance of AML

Standoff between a mutated gene and normal counterpart keeps certain cancer cells alive

Insulin interaction map could lead to new therapeutic targets for type 2 diabetes

FDA grants accelerated approval to Perjeta for neoadjuvant treatment of breast cancer

Researchers discover how aspirin improves survival in patients diagnosed with colon cancer

Shortage of zinc may contribute to diseases like Alzheimer's and Parkinson's

Researchers show that men experience more harm than good from routine PSA screening

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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