Mutation News and Research

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Colon has safety mechanism to restrict formation and growth of adenomas

Colon cancer development starts with the formation of benign tumours called adenomas. It is estimated that between 30% and 50% of people over 50 will develop one of these tumours.

24 Jun 2014

Clusters of protein linked to cancer warp cell membranes

Supercomputer simulations have shown that clusters of a protein linked to cancer warp cell membranes, according to scientists at The University of Texas Health Science Center at Houston (UTHealth) Medical School.

24 Jun 2014

Clovis Oncology begins TIGER2 study for treatment of NSCLC patients with EGFR/T790M mutations

Clovis Oncology, Inc. announced today that the TIGER2 study has commenced with the dosing of the first patient at a U.S. study site.

23 Jun 2014

FGFR1 amplification predicts poor outcome in early-stage NSCLC

Amplification of fibroblast growth factor receptor 1 is associated with poor clinical outcome in patients with early-stage non-small-cell lung cancer, Swiss researchers report.

20 Jun 2014

Greenlander study identifies single mutation with large diabetes risk

Researchers have used a Greenlandic cohort to identify a genetic mutation whose effect on the risk of diabetes is “several times larger” than any previously discovered.

20 Jun 2014

UCLA study sheds light on the development of lung cancer

UCLA researchers led by Dr. Brigitte Gomperts have discovered the inner workings of the process thought to be the first stage in the development of lung cancer. Their study explains how factors that regulate the growth of adult stem cells that repair tissue in the lungs can lead to the formation of precancerous lesions.

20 Jun 2014

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Pancreatic cancer tumors addicted to mutant Kras signaling for their growth and progression have a ready-made substitute to tap if they're ever forced to go cold-turkey on the mutant oncogene, scientists at The University of Texas MD Anderson Cancer Center report in the journal Cell.

20 Jun 2014

Clinical trial shows that selumetinib drug can delay progression of metastatic uveal melanoma

For the first time, a therapy has been found that can delay progression of metastatic uveal melanoma, a rare and deadly form of melanoma of the eye.

20 Jun 2014

Clinically relevant mouse model for difficult-to-treat squamous cell lung cancer

Only 15% of patients with squamous cell lung cancer - the second most common lung cancer - survive five years past diagnosis.

20 Jun 2014

Research provides unique insight into lncRNAs that regulate lung development

It's a long way from DNA to RNA to protein, and only about two percent of a person's genome is eventually converted into proteins.

19 Jun 2014

Researchers discover crucial process that regulates development of blood vessels

Biologists at The Scripps Research Institute (TSRI) have discovered a crucial process that regulates the development of blood vessels.

19 Jun 2014

Researchers find shared genetic link in autoimmune response among PV patients

Autoimmune disease occurs when the body's own natural defense system rebels against itself. One example is pemphigus vulgaris (PV), a blistering skin disease in which autoantibodies attack desmoglein 3 (Dsg3), the protein that binds together skin cells.

19 Jun 2014

U of MD researchers to use $3.7 million NIH grant to develop novel method to treat monogenic diabetes

The National Institutes of Health has awarded a four-year, $3.7 million grant to researchers at the University of Maryland School of Medicine to develop a personalized medicine program to help doctors diagnose and treat monogenic diabetes - a form of diabetes caused by a mutation in a single gene.

19 Jun 2014

Common mutation in gene with overweight results in elevated ALAT values in children

A study carried out at the Institute of Biomedicine of the University of Eastern Finland shows that a common mutation in the PNPLA3 gene combined with overweight results in elevated ALAT values in children.

18 Jun 2014

New breakthrough in pediatric leukaemia treatment

Melbourne researchers have shown a type of leukaemia can be successfully 'reversed' by coaxing the cancer cells back into normal development.

18 Jun 2014

U-M researchers detail new discoveries about basic biology of dystonia

Twist and hold your neck to the left. Now down, and over to the right, until it hurts. Now imagine your neck - or arms or legs - randomly doing that on their own, without you controlling it.

18 Jun 2014

UT Southwestern launches regional brain tissue collection program

To promote greater understanding of autism, UT Southwestern Medical Center has launched a regional brain tissue collection program that will support research on this condition, which affects an estimated one in 68 children.

18 Jun 2014

Researchers discover that genetic pathway could slow spread of ovarian cancer

University of Adelaide research into the origins of ovarian cancer has led to the discovery of a genetic pathway that could slow the spread of the cancer.

18 Jun 2014

Scottsdale Healthcare, TGen initiate AG-120 clinical trial in patients with solid tumors

The Virginia G. Piper Cancer Center at Scottsdale Healthcare and the Translational Genomics Research Institute are studying the safety and effectiveness of a new drug, AG-120, for treatment of patients with solid tumors, especially those with brain tumors and gallbladder bile duct cancer.

18 Jun 2014

Researchers identify new mechanism by which normal cells turn malignant in mammary epithelial tissues

A team of researchers led by David J. Mooney, Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences, have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

17 Jun 2014

Mutation News and Research

Colon has safety mechanism to restrict formation and growth of adenomas

Clusters of protein linked to cancer warp cell membranes

Clovis Oncology begins TIGER2 study for treatment of NSCLC patients with EGFR/T790M mutations

FGFR1 amplification predicts poor outcome in early-stage NSCLC

Greenlander study identifies single mutation with large diabetes risk

UCLA study sheds light on the development of lung cancer

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Clinical trial shows that selumetinib drug can delay progression of metastatic uveal melanoma

Clinically relevant mouse model for difficult-to-treat squamous cell lung cancer

Research provides unique insight into lncRNAs that regulate lung development

Researchers discover crucial process that regulates development of blood vessels

Researchers find shared genetic link in autoimmune response among PV patients

U of MD researchers to use $3.7 million NIH grant to develop novel method to treat monogenic diabetes

Common mutation in gene with overweight results in elevated ALAT values in children

New breakthrough in pediatric leukaemia treatment

U-M researchers detail new discoveries about basic biology of dystonia

UT Southwestern launches regional brain tissue collection program

Researchers discover that genetic pathway could slow spread of ovarian cancer

Scottsdale Healthcare, TGen initiate AG-120 clinical trial in patients with solid tumors

Researchers identify new mechanism by which normal cells turn malignant in mammary epithelial tissues

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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