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Researchers explore use of miR-192 as clinical marker for pancreatic cancer

Pancreatic cancer is regarded as the cancer type with the lowest survival rates. Fewer than seven in 100 patients survive the first five years after diagnosis. Clinicians attribute this devastating prognosis to two circumstances: Pancreatic cancers often do not cause any signs or symptoms and by the time they are detected they have already reached a very advanced stage in most cases.

2 Jun 2016

New mouse model offers more insight into development of ASD in humans

A new mouse model, developed by researchers at the University of Wisconsin-Madison, is the first to show that when more of a specific biological molecule moves between different parts of nerve cells in the mouse brain, it can lead to behaviors that resembles some aspects of autism spectrum disorder (ASD) in humans.

2 Jun 2016

New IRAP inhibitors may hold promise for improving cognitive functions in animal models

Researchers have discovered three new inhibitors of insulin-regulated aminopeptidase (IRAP), compounds shown to improve cognitive functions in animal models of human disorders.

2 Jun 2016

Duke scientists discover new small-molecule drugs to treat chronic pain

A research team at Duke University has discovered a potential new class of small-molecule drugs that simultaneously block two sought-after targets in the treatment of pain.

1 Jun 2016

Toxic substance acrolein may play role in preventing fibrillation linked to Alzheimer's disease

Scientists from RIKEN in Japan have discovered that acrolein—a toxic substance produced in cells during times of oxidative stress—in fact may play a role in preventing the process of fibrillation, an abnormal clumping of peptides that has been associated with Alzheimer's disease and other neural diseases.

1 Jun 2016

Understanding how opiates affect brain pathways to drive addiction cycle

New research by Steven Laviolette's research team at Western University is contributing to a better understanding of the ways opiate-class drugs modify brain circuits to drive the addiction cycle.

1 Jun 2016

TSRI scientists develop first drug candidate that neutralizes disease-causing RNA repeats

In an important new study with implications for the treatment of dozens of incurable diseases, scientists from the Florida campus of The Scripps Research Institute have for the first time created a drug candidate that attacks and neutralizes the RNA structure that causes an incurable progressive, inherited disease involving a gradual loss of control over body movement.

1 Jun 2016

Study provides new insights into molecular basis of CaSR-related human diseases

A study led by researchers at Georgia State University provides new insights into the molecular basis of human diseases resulting from mutations in the calcium-sensing receptor (CaSR), a protein found in cell membranes.

1 Jun 2016

Researchers design ProAgio protein that may potentially treat cancer, other illnesses

A protein designed by researchers at Georgia State University can effectively target a cell surface receptor linked to a number of diseases, showing potential as a therapeutic treatment for an array of illnesses, including cancer, according to the research team.

1 Jun 2016

New experimental drug may prevent stress damage in the brain

Chronic stress can make us worn-out, anxious, depressed--in fact, it can change the architecture of the brain.

31 May 2016

New research uncovers vital role of DHHC9 enzyme in brain circuit development

Research by Dr. Shernaz Bamji, from the University of British Columbia, uncovers the mechanism of action of an enzyme called DHHC9 in the normal development and function of neural networks in the brain.

31 May 2016

New CRISPR-EZ method makes genome editing much easier in mice

University of California, Berkeley scientists have developed a quicker and more efficient method to alter the genes of mice with CRISPR-Cas9, simplifying a procedure growing in popularity because of the ease of using the new gene-editing tool.

28 May 2016

Increasing specific microRNA levels can restore chemotherapy sensitivity in pancreatic cancer cells

By increasing the level of a specific microRNA (miRNA) molecule, researchers have for the first time restored chemotherapy sensitivity in vitro to a line of human pancreatic cancer cells that had developed resistance to a common treatment drug.

27 May 2016

NR supplements can reduce diabetes-related complications in mice

A naturally occurring vitamin, nicotinamide riboside (NR), can lower blood sugar levels, reduce fatty liver, and prevent peripheral nerve damage in mouse models of prediabetes and type 2 diabetes (T2D), according to a new study by researchers at the University of Iowa and the Iowa City VA Health Care System.

27 May 2016

New understanding of neurotransmitter transporter mechanism gives hope for treating depression, addicition

When nerve cells have to communicate with each other in our brains, it involves release of small signal molecules, the so-called neurotransmitters, which act as chemical messengers in specific points of contact between nerve cells, called synapses.

27 May 2016

Novel method for designing geometric structures created from DNA

Among the valuable holdings in London's Wellcome Library is a rough pencil sketch made in 1953 by Francis Crick. The drawing is one of the first to show the double-helix structure of DNA--Nature's blueprint for the design of sea snails, human beings, and every other living form on earth.

27 May 2016

Drexel scientists identify how two new antimalarial drugs work

Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite's skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream.

27 May 2016

Small drug-like molecule that alters perception of food may hold key to extending human healthspan

Researchers at the Buck Institute have shown a new effect on aging via a small drug-like molecule that alters the perception of food in the nematode C. elegans. Publishing in Aging Cell, researchers "tricked" the worm's metabolism into a state of caloric restriction, extending the animal's lifespan by 50 percent.

27 May 2016

TSRI scientists discover new method for harnessing venoms for therapeutic use

There are lessons to be learned from venoms. Scorpions, snakes, snails, frogs and other creatures are thought to produce tens or even hundreds of millions of distinct venoms. These venoms have been honed to strike specific targets in the body.

26 May 2016

Researchers spot molecular key that breast cancer cells use to invade bone marrow

Scientists at the Duke Cancer Institute have identified a molecular key that breast cancer cells use to invade bone marrow in mice, where they may be protected from chemotherapy or hormonal therapies that could otherwise eradicate them.

26 May 2016

Molecule News and Research

Researchers explore use of miR-192 as clinical marker for pancreatic cancer

New mouse model offers more insight into development of ASD in humans

New IRAP inhibitors may hold promise for improving cognitive functions in animal models

Duke scientists discover new small-molecule drugs to treat chronic pain

Toxic substance acrolein may play role in preventing fibrillation linked to Alzheimer's disease

Understanding how opiates affect brain pathways to drive addiction cycle

TSRI scientists develop first drug candidate that neutralizes disease-causing RNA repeats

Study provides new insights into molecular basis of CaSR-related human diseases

Researchers design ProAgio protein that may potentially treat cancer, other illnesses

New experimental drug may prevent stress damage in the brain

New research uncovers vital role of DHHC9 enzyme in brain circuit development

New CRISPR-EZ method makes genome editing much easier in mice

Increasing specific microRNA levels can restore chemotherapy sensitivity in pancreatic cancer cells

NR supplements can reduce diabetes-related complications in mice

New understanding of neurotransmitter transporter mechanism gives hope for treating depression, addicition

Novel method for designing geometric structures created from DNA

Drexel scientists identify how two new antimalarial drugs work

Small drug-like molecule that alters perception of food may hold key to extending human healthspan

TSRI scientists discover new method for harnessing venoms for therapeutic use

Researchers spot molecular key that breast cancer cells use to invade bone marrow

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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