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Researchers partially restore lost function of isolated cystic fibrosis lung cells

In experiments with isolated cystic fibrosis lung cells, University of Alabama at Birmingham researchers and colleagues from two other institutions have partially restored the lost function of those cells.

26 May 2016

PET imaging with PiB may help in early diagnosis of Alzheimer's disease

The effort to find ways to detect and diagnose preclinical Alzheimer's disease (AD) has taken a big step forward with the use of positron emission tomography (PET), a "nuclear medicine" for imaging processes in the body, when PET is used with a special 'tracer' that binds to the amyloid plaques in the brain that are a characteristic cause of AD.

25 May 2016

Single enzyme doing the work of a trio could offer precise way to treat diseases

Researchers identified a single enzyme doing the work of a trio thought necessary to control a common cellular signaling process being pursued as a therapeutic target.

24 May 2016

Researchers discover new potential treatment target for liver cancer

Researchers at the University of Eastern Finland and Eberhard Karls Universität Tübingen have discovered a new molecular mechanism that can be used to inhibit the growth of hepatocellular carcinoma, which is the most common liver cancer.

24 May 2016

Chloride switch controls critical step in basement membrane formation

Chloride plays a key role in the formation of the basement membrane, a suprastructure on the outside of cells that undergirds and guides the function of most of the tissues of the body.

24 May 2016

Purdue researchers find potential way to overcome limitations posed by CAR T-cell therapy

Purdue University researchers may have figured out a way to call off a cancer cell assassin that sometimes goes rogue and assign it a larger tumor-specific "hit list."

24 May 2016

Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

The lab of Rice University synthetic organic chemist K.C. Nicolaou has reported the streamlined total synthesis of delta12-prostaglandin J3, a molecule previously claimed to kill leukemic cancer cells.

24 May 2016

Chemical compound eCF506 may be highly effective at blocking growth of breast cancer cells

A drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research.

24 May 2016

Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

The investigational anticancer therapeutic abemaciclib, which targets CDK4 and CDK6, showed durable clinical activity when given as continuous single-agent therapy to patients with a variety of cancer types, including breast cancer, non-small cell lung cancer (NSCLC), glioblastoma, and melanoma, according to results from a phase I clinical trial.

23 May 2016

Cornell researchers develop nanoparticle-based drug delivery mechanism for combination cancer therapy

A team of researchers from Cornell University in Ithaca, New York demonstrated a drug delivery mechanism that utilizes two independent vehicles, allowing for delivery of chemically and physically dis-tinct agents.

23 May 2016

High-resolution image of Zika virus helicase may help develop antiviral drugs

A team led by researchers from Tianjin University has solved the structure of the Zika virus helicase, which is a key target for antiviral development. The research is published in Springer's journal Protein & Cell.

23 May 2016

Harvard researchers create new, simplified platform for antibiotic discovery

Harvard researchers have created a new, greatly simplified, platform for antibiotic discovery that may go a long way to solving the crisis of antibiotic resistance.

23 May 2016

Inhibiting palmitate-adding enzyme can make cancer cells sensitive to EGFR inhibitors

The mistaken activation of certain cell-surface receptors contributes to a variety of human cancers. Knowing more about the activation process has led researchers to be able to induce greater vulnerability by cancer cells to an existing first-line treatment for cancers (mainly lung) driven by a receptor called EGFR.

23 May 2016

Wresting back control of CHI3L1 protein could stave off cancer spread in mice

For cancer to spread, the cells that take off into the bloodstream must find a tissue that will permit them to thrive. They don't just go looking, though. Instead, they actively prepare the tissue, in one case by co-opting a protein that suppresses defenses the body would otherwise mount.

21 May 2016

AstraZeneca, MedImmune to provide update on extensive oncology pipeline at ASCO 2016

AstraZeneca and its global biologics research and development arm, MedImmune, will provide an update on their extensive oncology pipeline at the annual meeting of the American Society of Clinical Oncology in Chicago, USA, on 3-7 June 2016.

20 May 2016

Distek launches BIOne benchtop scale single-use bioreactor system

From the company that has brought you 40 years of excellence in laboratory pharmaceutical instruments, Distek, Inc. is proud to introduce the BIOne Single-Use Bioreactor System.

20 May 2016

Study examines effects of ultra-low doses of glyphosate on gene expression profiles

Glyphosate, often sold under the brand name of Roundup, is the world's most widely used weed-killer. While Glyphosate has approval from regulatory bodies worldwide, there are growing concerns about its possible adverse health effects.

20 May 2016

TAK1 deficit protects mice from obesity

Obesity and subsequent complications are increasing in frequency worldwide. The accumulation of adipose tissue is associated with increased inflammation, and it has been proposed that modification of proinflammatory responses could alter adipose tissue composition.

20 May 2016

Biosensor can detect molecules linked to neurodegenerative diseases, cancer

A biosensor developed by researchers at the National Nanotechnology Laboratory in Campinas, São Paulo State, Brazil, has been proven capable of detecting molecules associated with neurodegenerative diseases and some types of cancer.

20 May 2016

Microglia plays vital role in reducing effects of cocaine in the brain

A type of brain cell known as microglia plays a key role in reducing the effects of cocaine in the brain, according to a major study by a team from the Research Institute of the McGill University Health Centre in Montreal.

20 May 2016

Molecule News and Research

Researchers partially restore lost function of isolated cystic fibrosis lung cells

PET imaging with PiB may help in early diagnosis of Alzheimer's disease

Single enzyme doing the work of a trio could offer precise way to treat diseases

Researchers discover new potential treatment target for liver cancer

Chloride switch controls critical step in basement membrane formation

Purdue researchers find potential way to overcome limitations posed by CAR T-cell therapy

Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

Chemical compound eCF506 may be highly effective at blocking growth of breast cancer cells

Investigational drug abemaciclib shows durable clinical activity for variety of cancer types

Cornell researchers develop nanoparticle-based drug delivery mechanism for combination cancer therapy

High-resolution image of Zika virus helicase may help develop antiviral drugs

Harvard researchers create new, simplified platform for antibiotic discovery

Inhibiting palmitate-adding enzyme can make cancer cells sensitive to EGFR inhibitors

Wresting back control of CHI3L1 protein could stave off cancer spread in mice

AstraZeneca, MedImmune to provide update on extensive oncology pipeline at ASCO 2016

Distek launches BIOne benchtop scale single-use bioreactor system

Study examines effects of ultra-low doses of glyphosate on gene expression profiles

TAK1 deficit protects mice from obesity

Biosensor can detect molecules linked to neurodegenerative diseases, cancer

Microglia plays vital role in reducing effects of cocaine in the brain

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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