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Determining Microsatellite Instability Status Using Multiplex PCR-Based Methods

Determining microsatellite instability status using multiplex PCR-based methods used to screen for Lynch Syndrome, a dominant hereditary cancer propensity.

From Promega Corporation 24 Jan 2020

First glioblastoma patient treated with genetically modified poliovirus at UH

University Hospitals Seidman Cancer Center treated its first patient in a new clinical trial to validate the groundbreaking effects of the poliovirus on glioblastoma, a deadly Grade IV cancer of the brain.

24 Jan 2020

A single number aids biomedical data scientists in finding deadly cancer cells

Biomedical data scientists at the Stanford University School of Medicine have shown that the number of genes a cell uses to make RNA is a reliable indicator of how developed the cell is, a finding that could make it easier to target cancer-causing genes.

24 Jan 2020

Meridian launches High-Specificity Pfu HS Mix to increase customers’ testing capabilities

Meridian Bioscience, Inc. today announced the launch of a High-Specificity Pfu HS Mix that not only provides high-fidelity amplification, but also offers market-leading amplification for companion diagnostic (CDx) and clinical testing.

From Meridian Bioscience, Inc. 24 Jan 2020

Iron overload, variant gene and malaria resistance linked in African study

A new study shows that a rare genetic mutation giving rise to a variant of the TP53 gene called P47S causes several linked biological processes.

24 Jan 2020

RB1 alterations in cancer cells may lead to treatment resistance

The Cancer Genetics Group of the Josep Carreras Leukaemia Research Institute, led by Montse Sánchez-Céspedes, together with Luis Montuenga from CIMA, and Enriqueta Felip from Vall d'Hebron Hospital, has revealed that inactivation of RB1 through intragenic rearrangements is frequent in lung cancer cells from non-smoking patients with EGFR mutations.

24 Jan 2020

Halting metastasis by preventing cancer cells from using fat

Healthy cells normally undergo cell division, but when a genetic mutation causes uncontrolled cell growth, they form a tumor. Cancer is one of the leading causes of death worldwide, and most deaths happen when cancer cells start to metastasize or travel from the mother tumor to other parts of the body.

23 Jan 2020

New Distinguished Scholar Award aims to mitigate gender gaps in medical research

The Icahn School of Medicine at Mount Sinai - an international leader in medical and scientific training, biomedical research, and patient care - today announced the recipients of the first-of-its-kind Distinguished Scholar Award, a new annual grant sponsored by the Office of Gender Equity in Science and Medicine. The awards aim to mitigate gender gaps in medical research by supporting researchers with additional project resources while they serve as family caretakers.

23 Jan 2020

Novel drug can simultaneously help diagnose, treat gastric cancer

A novel drug, named "FerriIridium", can simultaneously help diagnose and treat gastric cancer. The initially weakly active precursor (prodrug), based on an iridium-containing compound, is selectively activated only after reaching the interior of a tumor cell. This is possible because of the higher amount of iron present there, report scientists in the journal Angewandte Chemie.

23 Jan 2020

A two-drug combo that halts growth of cancer cells discovered

UT Southwestern Simmons Cancer Center researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations.

23 Jan 2020

Immune system cells facilitate the invasive capacity of glioblastoma

In a study published in Brain Communications, a new Open Access publication of the well-known journal Brain, the team led by Carlos Barcia, researcher at Institut de Neurociències of the Universitat Autònoma de Barcelona, analyzed the role of immune cells in the expansion of glioblastoma, the most aggressive brain tumor.

23 Jan 2020

Scientists discover new drug target for prostate cancer in the non-coding genome

Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.

23 Jan 2020

Protein p38 plays key role in supporting lung cancer growth

In 2018, 1.7 million people died from lung cancer worldwide, a number equivalent to the population of Barcelona. The high mortality rate of lung cancer reflects the need for the development of treatments that are more efficient.

23 Jan 2020

A menu of treatments for glioblastoma

Sara Piccirillo, PhD, is passionate about finding a way to beat glioblastoma, the most aggressive type of brain cancer.

23 Jan 2020

Protein linked with neurodegenerative diseases may help explore the aggressive behavior of gliomas

A protein typically associated with neurodegenerative diseases like Alzheimer's might help scientists explore how gliomas, a type of cancerous brain tumor, become so aggressive.

22 Jan 2020

GW expands clinical trial of neoadjuvant immunotherapy for high-risk cutaneous squamous cell carcinoma

The Cutaneous Oncology Program at the George Washington University (GW) Cancer Center was selected as the first global site for a clinical trial for patients with high-risk cutaneous squamous cell carcinoma.

22 Jan 2020

PET/MRI identifies potentially useful breast cancer biomarkers

Researchers have identified several potentially useful breast cancer biomarkers that indicate the presence and risk of malignancy, according to new research published in the January issue of The Journal of Nuclear Medicine.

22 Jan 2020

'Innovative Research Award' helps CU scientists to explore BRAF inhibition resistance in brain cancer

Cancers used to be defined by where they grow in the body - lung cancer, skin cancer, brain cancer, etc. But work in recent decades has shown that cancers sharing specific genetic changes may have more in common than cancers that happen to grow in an area of the body.

21 Jan 2020

Patient-specific tumor organoids may one day be used to personalize cancer treatment

A patient-specific tumor organoid platform developed by Wake Forest Institute for Regenerative Medicine researchers and their cancer center colleagues could someday take the guessing game out of immunotherapy treatments.

21 Jan 2020

Novel artificial intelligence system reveals genes that drive tumor growth

A method for finding genes that spur tumor growth takes advantage of machine learning algorithms to sift through reams of molecular data collected from studies of cancer cell lines, mouse models and human patients.

21 Jan 2020