Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Gene regulation determines human-chimp differences

The vast differences between humans and chimpanzees are due more to changes in gene regulation than differences in individual genes themselves

9 Mar 2006

New genome-wide map of miRNA-MRNA interactions

Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans).

9 Mar 2006

Metabolic switch required for cellular adaptation to hypoxia

Two new studies in the March Cell Metabolism reveal a survival mechanism by which cells adapt to oxygen starvation by ratcheting down their demand.

9 Mar 2006

As children transform into adults some of the genes involved in controlling their blood pressure change as well

The study of black and white identical and fraternal twins showed that changes in gene expression between ages 14 and 18 accounted for up to one third of the blood pressure variation that occurred by age 18, says Dr. Harold Snieder, genetic epidemiologist at the Medical College of Georgia.

7 Mar 2006

Why people of African descent are more vulnerable to tuberculosis infection

A team of scientists has identified a cellular mechanism that may help explain the puzzle of why people of African descent are more susceptible to tuberculosis infection and why, once infected, they develop more severe states of the disease than whites.

27 Feb 2006

Scientists discover genetic profile eosinophilic esophagitis

Though many parents may never have heard of it, a severe and chronic condition called eosinophilic esophagitis (EE) is recognized by doctors as an emerging health problem for children.

24 Feb 2006

Inflammatory reaction drives hormone resistance in cancer

In the journal Cell, researchers report new evidence to explain why prostate cancer and other hormone-dependent cancers may become resistant to hormone therapies.

21 Feb 2006

X chromosome dosage compensation occurs in germ cells

X chromosome dosage compensation does occur in germ cells. A study published today in the open access journal Journal of Biology reveals that expression of the genes on the X chromosome is doubled in Drosophila germ cells to compensate for the missing second X chromosome.

17 Feb 2006

New method determines in a matter of hours exposure to a bioterrorism agents

Researchers at Walter Reed Army Institute of Research are developing a method to determine in a matter of hours if someone has been exposed to a bioterrorism agent just by looking at the pattern of active genes in that person's white blood cells.

17 Feb 2006

New insight into pathogenic mechanisms underlying basal-like breast cancers

Basal-like breast cancers (BLC) are highly aggressive tumors with a relatively poor prognosis that account for approximately 15% of sporadic human breast cancer.

16 Feb 2006

X chromosome dosage compensation proven in germ cells

16 Feb 2006

Protein associated with growth of tumors may prevent the spread of cancer

A protein associated with the growth of head and neck tumors may be a tumor suppressor that could prevent the spread of cancer when it is expressed above normal levels, according to a study published in the Journal of the National Cancer Institute (JNCI).

13 Feb 2006

Eosinophilic esophagitis gene discovery

Researchers at Cincinnati Children's Hospital Medical Center have discovered the first gene associated with eosinophilic esophagitis, one of a number of eosinophil-related diseases in which the body produces abnormally large amounts of white blood cells that can lead to allergy related illnesses.

7 Feb 2006

miRNA emerge as a class of gene regulators

Scientists have discovered that a wide variety of different cancers actually share something in common - a molecular "signature" made up of tiny bits of genetic material called microRNA (miRNA) that target key cancer genes and promote malignant growth.

7 Feb 2006

60 new genes controlled by regulatory sequences

Researchers worldwide are seeking to define ancient sections of our genetic code that may soon be as important to medical science as genes.

2 Feb 2006

BRCA1 gene inhibits estrogen and progesterone

It's been known that the breast cancer susceptibility gene BRCA1 regulates use of estrogen in breast and other cells, but now researchers at Georgetown University Medical Center have discovered that it also controls activity of a second sex steroid hormone, progesterone.

27 Jan 2006

New tool for genetic research

In an article appearing online today in the journal Nature Methods, researchers at the EPFL (Ecole Polytechnique Fidirale de Lausanne) unveil a powerful new tool that will facilitate genetic research and open up new avenues for the clinical treatment of genetic disease.

23 Jan 2006

New microRNA mechanism for regulating brain function

Non-coding regions of the genome - those that don't code for proteins - are now known to include important elements that regulate gene activity. Among those elements are microRNAs, tiny, recently discovered RNA molecules that suppress gene expression.

18 Jan 2006

Compounds in blackcurrants could prevent Alzheimer's disease

Compounds in blackcurrants could prevent Alzheimer's disease and the characteristics of British berries suggest they do it best, writes Jennifer Rohn in Chemistry & Industry magazine.

18 Jan 2006

Cloned stem cells are perfectly normal

Scientists generally agree that all cloned animals are biologically flawed. But they don't agree about what that means for stem cells derived from cloned embryos, the basis for therapeutic cloning.

18 Jan 2006