Cellular Biology News and Research

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Connectome remains dynamic during development, says Scripps Research

Connected highways of nerve cells carry information to and from different areas of the brain and the rest of the nervous system. Scientists are trying to draw a complete atlas of these connections-sometimes referred to as the "connectome"-to gain a better understanding of how the brain functions in health and disease.

28 Jan 2011

Scripps Research receives NIH grant to develop therapies for circadian rhythm disorders

The Scripps Research Institute has been awarded $3.17 million over four years to develop compounds that will counteract disruptions of the human biological clock - the circadian rhythm that regulates our patterns of activity and rest over a 24-hour daily cycle.

19 Jan 2011

Vanderbilt, Scripps Research form partnership to open new institute

The Scripps Research Institute and Vanderbilt University have formed a partnership to advance science at the interface of chemistry and medicine, the institutions announced today.

14 Jan 2011

Personal genetic tests have promising effects on consumers

New findings from a landmark research study led by Scripps Health and the Scripps Translational Science Institute (STSI) reveal that personal genetic tests have some promising effects on consumers who choose to undergo the screenings. STSI is an initiative of Scripps Health in collaboration with The Scripps Research Institute.

13 Jan 2011

NIDA awards Scripps Research, University of Pennsylvania $8.2M grant to develop tobacco addiction treatment

The Scripps Research Institute and the University of Pennsylvania School of Medicine have been awarded approximately $8.2 million over five years to develop novel compounds that could eventually become drug candidates for the treatment of tobacco addiction. Of the funds awarded, $5.7 million will go to Scripps Research, and $2.5 million to the University of Pennsylvania.

12 Jan 2011

All fat cells not the same

All fat cells are not the same - a fact that has implications in the understanding and treatment of type 2 diabetes and obesity, said researchers from Baylor College of Medicine (www.bcm.edu) in a report that appears in the current issue of the Journal of Cell Biology (http://www.jcb.rupress.org/).

10 Jan 2011

University of Michigan lab takes top honours in worldwide protein prediction competition

The University of Michigan Health System took top honors in the Critical Assessment of Techniques for Protein Structure Prediction, a biennial scientific competition to test protein structure and function prediction methods developed by laboratories all over the world.

5 Jan 2011

Unique vaccine produces long-lasting anti-cocaine immunity in mice

Researchers from The Scripps Research Institute, Weill Cornell Medical College, and Cornell University have produced a long-lasting anti-cocaine immunity in mice by giving them a unique vaccine that combines bits of the common cold virus with a particle that mimics cocaine.

5 Jan 2011

Researchers develop unique vaccine that produces long-lasting anti-cocaine immunity in mice

5 Jan 2011

Single cancer cell could be detected in future using new test

Soon scientists will be able to detect a single cancer cell among the billions of cells that circulate in the human bloodstream. The method could detect whether the therapy has worked or even show which therapy would work best. The test depends on circulating tumor cells (CTCs) or cancer cells that have detached from the main tumor and are traveling to other parts of the body.

4 Jan 2011

CDK1 protein deactivates EZH2 enzyme that causes cancer spread

By sticking a chemical group to it at a specific site, a protein arrests an enzyme that may worsen and spread cancer, an international research team led by scientists at The University of Texas MD Anderson Cancer Center reports in the January issue of Nature Cell Biology.

4 Jan 2011

Molecular interaction between structural HCV protein and protein critical to viral replication identified

Scientists from the Florida campus of The Scripps Research Institute have identified a molecular interaction between a structural hepatitis C virus protein (HCV) and a protein critical to viral replication. This new finding strongly suggests a novel method of inhibiting the production of the virus and a potential new therapeutic target for hepatitis C drug development.

29 Dec 2010

Scientist discovers molecular switch controlling synthesis of ribosomes

A scientist from the Florida campus of The Scripps Research Institute has discovered a molecular switch that controls the synthesis of ribosomes. Ribosomes are the large machineries inside all living cells that produce proteins, the basic working units of any cell. These new findings offer a novel target for potential treatments for a range of diseases, including cancer.

23 Dec 2010

NIH grants $7.5 million for researchers to develop novel compounds in treating nicotine addiction

The Scripps Research Institute and the University of California, San Diego, School of Medicine have been awarded approximately $7.5 million over five years to develop novel compounds that could eventually become drug candidates for the treatment of nicotine dependence, and possibly other drug addictions.

16 Dec 2010

Researchers generate insulin-secreting pancreatic islet cells from human SSCs

Insulin-secreting pancreatic islet cells have been generated from human spermatogonial stem cells (SSCs) directly isolated from human testicular tissue, researchers reported today at the American Association of Cell Biology 50th Annual Meeting in Philadelphia.

13 Dec 2010

Researchers discover central switch that regulates movement of cancer cells

Researchers at the University of Georgia have discovered a central switch that controls whether cells move or remain stationary. The misregulation of this switch may play a role in the increased movement of tumor cells and in the aggressiveness of tumors themselves.

9 Dec 2010

NIH awards Scripps Research $2.35M to study new treatment for obesity

The Scripps Research Institute has been awarded a $2.35 million grant from the National Institutes of Health to study a new way of treating obesity as part of a national consortium with the Dana-Farber Cancer Institute.

8 Dec 2010

New approach to biomarker detection for early lung cancer diagnosis

Even with astounding advances in genomic science, genetic analysis of disease remains largely a measure of risk rather than actual disease state. A truer and more immediate measure of health can be obtained by analysis of proteins, especially those that are biomarkers of disease state.

2 Dec 2010

Exposure to BPA during perinatal development impairs reproductive capacity of female offspring

Exposure to a ubiquitous environmental chemical during pregnancy may impair reproductive capacity of female offspring, according to a study published online in advance of print on December 2 in Environmental Health Perspectives. Fertility decreased over time in female mice that had been exposed during fetal and neonatal (perinatal) development to doses of bisphenol-A (BPA) that were lower than or equal to human environmental exposure levels.

2 Dec 2010

Tension-dependent stabilization helps chromosome separation machinery

Scientists have discovered an amazingly simple way that cells stabilize their machinery for forcing apart chromosomes. Their findings are reported Nov. 25 in Nature.

25 Nov 2010

Cellular Biology News and Research

Connectome remains dynamic during development, says Scripps Research

Scripps Research receives NIH grant to develop therapies for circadian rhythm disorders

Vanderbilt, Scripps Research form partnership to open new institute

Personal genetic tests have promising effects on consumers

NIDA awards Scripps Research, University of Pennsylvania $8.2M grant to develop tobacco addiction treatment

All fat cells not the same

University of Michigan lab takes top honours in worldwide protein prediction competition

Unique vaccine produces long-lasting anti-cocaine immunity in mice

Researchers develop unique vaccine that produces long-lasting anti-cocaine immunity in mice

Single cancer cell could be detected in future using new test

CDK1 protein deactivates EZH2 enzyme that causes cancer spread

Molecular interaction between structural HCV protein and protein critical to viral replication identified

Scientist discovers molecular switch controlling synthesis of ribosomes

NIH grants $7.5 million for researchers to develop novel compounds in treating nicotine addiction

Researchers generate insulin-secreting pancreatic islet cells from human SSCs

Researchers discover central switch that regulates movement of cancer cells

NIH awards Scripps Research $2.35M to study new treatment for obesity

New approach to biomarker detection for early lung cancer diagnosis

Exposure to BPA during perinatal development impairs reproductive capacity of female offspring

Tension-dependent stabilization helps chromosome separation machinery

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