DNA Damage News and Research

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Researchers identify genes that regulate cellular senescence

A research group including Professor KAMADA Shinji, Research Fellow NAGANO Taiki (both from the Kobe University Biosignal Research Center), and Unit Chief ENARI Masato (National Cancer Research Institute) has succeeded in identifying genes that control cellular senescence - permanently arrested cell growth.

13 Sep 2016

Genome-wide studies reveal evolutionary conserved enzyme facilitates DNA replication

Genome-wide studies of fission yeast (Schizosaccharomyces pombe) suggest that the evolutionary conserved enzyme Pfh1 helicase facilitates DNA synthesis by tracking along with the replication apparatus, promoting intact DNA synthesis at hard-to-replicate sites and consequently suppressing DNA damage. The findings are published in PLOS Genetics.

12 Sep 2016

Researchers identify how ionising radiation can cause cancer by damaging DNA

For the first time, researchers from the Wellcome Trust Sanger Institute and their collaborators have been able to identify in human cancers two characteristic patterns of DNA damage caused by ionising radiation.

12 Sep 2016

Researchers uncover molecular differences between African and Asian strain of Zika virus infections

Scientists have revealed molecular differences between how the African and Asian strains of Zika virus infect neural progenitor cells.

1 Sep 2016

Research findings could lead to new biomarker for early stages of tumor development

To treat or not to treat? That is the question researchers at the Department of Energy's Lawrence Berkeley National Laboratory hope to answer with a new advance that could help doctors and their cancer patients decide if a particular therapy would be worth pursuing.

31 Aug 2016

Advanced imaging technique could help select embryos most viable for successful pregnancy

Researchers at the University of Adelaide have successfully trialed a new technique that could aid the process of choosing the "best" embryo for implantation, helping to boost the chances of pregnancy success from the very first IVF cycle.

26 Aug 2016

Seeds of tropical shrub guarana contain ten times more amount of catechins than green tea

The millions of people who consume green tea all over the world benefit from the catechins it contains.

22 Aug 2016

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Maintaining proper levels of an essential helper molecule is crucial for optimal muscle function, according to a study led by Joseph Baur, PhD, an assistant professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania.

10 Aug 2016

Study reveals unexpected process for acquiring chemoresistance in breast cancers

A laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes.

25 Jul 2016

New study sheds light on pathogenesis of DNA lesions present in leukemia

Researchers have succeeded in shedding light on the pathogenesis of DNA breakpoints that are associated with leukemia.

20 Jul 2016

CNIO study shows proinflammatory molecule IL-17A can be key factor in development of NASH and HCC

Non-alcoholic steatohepatitis (NASH) is a serious hepatic condition that precedes hepatocellular carcinoma (HCC) and is currently untreatable.

12 Jul 2016

Scientists develop new nonradioactive method to determine telomere length

UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging.

30 Jun 2016

Health-promoting bacteria may protect women from breast cancer

Bacteria that have the potential to abet breast cancer are present in the breasts of cancer patients, while beneficial bacteria are more abundant in healthy breasts, where they may actually be protecting women from cancer, according to Gregor Reid, PhD, and his collaborators.

25 Jun 2016

Researchers identify new potential target for pancreatic cancer treatment

Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports.

24 Jun 2016

Researchers use sensitive technique to reveal high levels of genetic heterogeneity in schizophrenia

International researchers centered at Nagoya University use a highly sensitive technique to identify significantly more DNA sequence repeats in patients with schizophrenia than in control individuals, and outline a possible link between genome instability and disease.

24 Jun 2016

Sperm of smokers has greater extent of DNA damage than that of non-smokers

A recent study found that that sperm of men who smoke has a greater extent of DNA damage than that of non-smokers.

22 Jun 2016

Researcher aims to develop easy-to-use, inexpensive sperm sorting devices to help infertile couples

The competition is fierce and only the strongest survive the obstacle course within the female reproductive tract. Of the millions of sperm that enter the vagina, only about 10 or so make it to the oocyte or egg, demonstrating how rigorous the natural sperm selection process really is.

17 Jun 2016

Researchers aim to protect kidneys while improving cisplatin's efficacy against cancer

Cisplatin is a common, powerful chemotherapy agent used for a wide range of cancers such as breast, ovarian and lung, that in a handful of days can also permanently damage or destroy patients' kidneys.

14 Jun 2016

CNIO researchers avoid genetic manipulation to create lab mice with extra-long telomeres

The Telomeres and Telomerase Group at the Spanish National Cancer Research Centre, in collaboration with the Centre's Transgenic Mice Core Unit, has succeeded in creating mice in the laboratory with hyper-long telomeres and with reduced molecular ageing, avoiding the use of what to date has been the standard method: genetic manipulation.

3 Jun 2016

Maintaining cardiomyocyte telomere length may enhance heart regeneration in adults

Researchers at the Spanish National Center for Cardiovascular Research have discovered that the ends of heart muscle cell chromosomes rapidly erode after birth, limiting the cells' ability to proliferate and replace damaged heart tissue.

31 May 2016