Preclinical News and Research

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CoQ10 shows promise in boosting female fertility by reviving aging eggs

Researchers reviewed evidence on Coenzyme Q10 (CoQ10) and found it may enhance mitochondrial function, improve oocyte quality, and counteract age-related fertility decline. The review highlights promising results from clinical, preclinical, and in vitro studies but calls for larger trials to confirm safety, dosing, and effectiveness.

16 Sep 2025

Novel biotechnical vector integrates viral and synthetic features for targeted cancer therapy

Gene therapy offers the possibility of addressing cancer at its molecular roots by targeting disease-causing genes rather than relying solely on surgery, chemotherapy, or radiotherapy.

16 Sep 2025

Inside the lab of the future: Automation, NMR, and the power of integration

Discover how Bruker is changing the future of labs and NMR through its R&D efforts.

From Bruker BioSpin Group 16 Sep 2025

Boosting PI31 to restore synaptic function and prevent neurodegeneration

One fundamental feature of neurodegenerative diseases is a breakdown in communication. Even before brain cells die, the delicate machinery that keeps neurons in touch-by clearing away protein waste at the synapses-starts to fail.

16 Sep 2025

Researchers receive new funding to advance promising therapy for multiple sclerosis

A Canadian-led international research team, spearheaded by Dr. Fang Liu at the Centre for Addiction and Mental Health (CAMH) has received nearly $800,000 US ($1,137,868 CAD) in new funding to advance a promising therapy for multiple sclerosis (MS).

15 Sep 2025

Genetic study shows dual GIPR/GLP1R action curbs binge alcohol use

Researchers used drug-target Mendelian randomization to test whether genetically proxied activation of GLP1R and GIPR influences alcohol-related behaviors. They found that GIPR, especially when combined with GLP1R, was linked to lower binge and heavy drinking, healthier food preferences, improved liver markers, and reduced coronary artery disease risk.

15 Sep 2025

Texas Tech research team earns $3 million renewal to advance stroke therapy

Stroke research aims to understand the brain's self-protective and repair mechanisms. Gaining detailed insight into these mechanisms is crucial as such knowledge could lead to newly developed medications and interventions which mimic or engage the brain's self-protective/repair mechanisms, leading to innovative stroke therapies.

13 Sep 2025

A universal solution emerges: Anti-linker antibodies simplify CAR-T detection and development

CAR-T cell therapy has demonstrated remarkable success in treating hematologic malignancies and is now expanding into solid tumors.

From Sino Biological Inc. 13 Sep 2025

Repurposed diabetes drugs boost CAR T therapy effectiveness in bladder cancer

Urothelial carcinoma (UC) is the second most common genitourinary cancer, leading to over 16,000 deaths a year in the United States. Despite recent advances, the 5-year survival rate for metastatic UC remains around five to ten percent.

12 Sep 2025

Infection or stressful events during pregnancy may increase anxiety risk in offspring

Increased risk for anxiety may begin before birth, shaped by infection or stressful events during pregnancy, according to a new preclinical study from researchers at Weill Cornell Medicine.

11 Sep 2025

Experts warn tiny plastics in arteries may raise heart attack risk

Experts caution that nanoplastics and microplastics may constitute an emerging cardiovascular risk factor, with particles identified in arterial plaques associated with a 4.5-fold increase in major adverse cardiovascular events. Experimental evidence points to inflammation, oxidative stress, and vascular injury as key mechanisms.

10 Sep 2025

Lung tumors rewire immune cells in the bone marrow before they reach cancer sites

Lung tumors don't just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy

10 Sep 2025

Mediterranean-style diet benefits maternal health during pregnancy and breastfeeding

A Mediterranean-style diet, rich in fiber, vegetable proteins and healthy fats, benefits maternal health during pregnancy and breastfeeding.

10 Sep 2025

New AI model can identify treatments that reverse disease states in cells

In a move that could reshape drug discovery, researchers at Harvard Medical School have designed an artificial intelligence model capable of identifying treatments that reverse disease states in cells.

10 Sep 2025

IFITM3 found to be critical regulator of immunotherapy sensitivity in small cell lung cancer

New research presented identifies interferon-induced transmembrane protein 3 (IFITM3) as a critical regulator of immunotherapy sensitivity in small cell lung cancer (SCLC), offering a promising new avenue for overcoming resistance to PD-1/PD-L1 checkpoint blockade.

9 Sep 2025

New tool can predict where deadly brain cancer might reappear

Glioblastoma is a devastatingly effective brain cancer. Doctors can cut it out or blast it with radiation, but that only buys time. The cancer has an insidious ability to hide enough tumor cells in tissue around the tumor to allow it to return as deadly as ever.

9 Sep 2025

Preclinical News and Research

CoQ10 shows promise in boosting female fertility by reviving aging eggs

Novel biotechnical vector integrates viral and synthetic features for targeted cancer therapy

Inside the lab of the future: Automation, NMR, and the power of integration

Boosting PI31 to restore synaptic function and prevent neurodegeneration

Researchers receive new funding to advance promising therapy for multiple sclerosis

Genetic study shows dual GIPR/GLP1R action curbs binge alcohol use

Texas Tech research team earns $3 million renewal to advance stroke therapy

A universal solution emerges: Anti-linker antibodies simplify CAR-T detection and development

Repurposed diabetes drugs boost CAR T therapy effectiveness in bladder cancer

Infection or stressful events during pregnancy may increase anxiety risk in offspring

Experts warn tiny plastics in arteries may raise heart attack risk

Lung tumors rewire immune cells in the bone marrow before they reach cancer sites

Mediterranean-style diet benefits maternal health during pregnancy and breastfeeding

New AI model can identify treatments that reverse disease states in cells

IFITM3 found to be critical regulator of immunotherapy sensitivity in small cell lung cancer

New tool can predict where deadly brain cancer might reappear

New hydrogel may help alleviate negative impacts of menopause

Blood-based biomarkers reveal barriers to diversity in Alzheimer’s disease trials

Targeting ADAR1 offers new hope against glioblastoma

Impaired spatial orientation found in older adults at risk for Alzheimer’s disease

Event guide: 4th LNP Formulation & Process Development Summit eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

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Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics