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LJI study could provide important target for autoimmune disease interventions

Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensable for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones.

3 May 2016

BioAFM Advancements

In this interview, News Medical talks to Dr. Thomas Mueller of Bruker Nano surface, about the advances in BioAFM.

From Bruker Nano Surfaces and Metrology 3 May 2016

Mitochondrial dysfunction linked to chemotherapeutic resistance in African-American men with prostate cancer

Improper functioning of the mitochondria, a cell's source of energy, may help account for the fact that African-American men with prostate cancer respond poorly to the same conventional therapies provided to Caucasian-American men, according to research led by Dhyan Chandra, PhD, Associate Professor of Oncology in the Department of Pharmacology and Therapeutics at Roswell Park Cancer Institute.

30 Apr 2016

CMGH study offers insight into future interventions for Crohn's disease, chronic pancreatitis

Cellular and Molecular Gastroenterology and Hepatology is committed to publishing impactful digestive biology research covering a broad spectrum of themes in GI, hepatology and pancreatology. We wanted to share two new CMGH articles, which both offer important insight into future interventions for chronic conditions.

30 Apr 2016

Predictive statistical approach opens door to development of more effective therapies for breast cancer

Designing effective new drugs, especially drugs to fight cancer, demands that you know as much as you can about the molecular workings of cancer growth. Without that, it's like planning to fight a war against an enemy you've never seen.

29 Apr 2016

University of Kaiserslautern uses JPK NanoWizard AFM to study bacterial interaction with microstructured surfaces

JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the research into the interaction of bacteria with microstructured surfaces in the Department of Physics at the University of Kaiserslautern in Germany.

From Bruker BioAFM 29 Apr 2016

University of Kaiserslautern uses JPK NanoWizard AFM to study bacterial interaction with microstructured surfaces

From Bruker BioAFM 29 Apr 2016

Experimental therapy has over 90% remission rate for advanced leukemia patients

Twenty-seven of 29 patients with an advanced type of leukemia that had proved resistant to multiple other forms of therapy went into remission after their T cells (disease-fighting immune cells) were genetically engineered to fight their cancers.

28 Apr 2016

IPC PAS‘s chemical sensor can rapidly and effectively detect fungal infections

Fungal infections are a serious problem in modern health care. A critical factor in their successful treatment is time: the faster they are detected, the more effectively dangerous infections can be prevented.

28 Apr 2016

Study reveals surprising results that may impair future therapeutic approaches in TGF-beta pathway

Researchers at Helmholtz Zentrum München describe how breast cancer cells challenged with a small-molecule inhibitor targeting specific invasive properties switch to an alternative mode-of-action, rendering them even more aggressive. The results may impair future therapeutic approaches in the TGF-beta pathway and are published in the journal 'Oncotarget'.

27 Apr 2016

New rat study shows specific genetic factors may contribute to differences in addiction among humans

Why does one person who tries cocaine get addicted, while another might use it and then leave it alone? Why do some people who kick a drug habit manage to stay clean, while others relapse? And why do some families seem more prone to addiction than others?

27 Apr 2016

New fruit fly model study reveals metabolic pathway that can be targeted to treat FXS patients

Fragile X syndrome (FXS) is the most common genetically inherited cause of intellectual disability in humans. New research shows how the hormone insulin -- usually associated with diabetes -- is involved in the daily activity patterns and cognitive deficits in the fruitfly model of FXS, according to a new study from the Perelman School of Medicine at the University of Pennsylvania published online this month in Molecular Psychiatry in advance of the print issue.

27 Apr 2016

First small molecule targeted therapy holds promise for Usher syndrome

Usher syndrome (USH) is characterized by hearing loss or deafness at birth and progressive vision loss, and is the most common cause of inherited dual sensory deficit. No treatment is currently available to stop or slow the progression of vision or hearing loss in USH3, one of three clinical classifications for USH that are further divided into subtypes and all associated with different genes.

27 Apr 2016

Newly published manuscripts enhance understanding of the immune system

MedImmune, the global biologics research and development arm of AstraZeneca, today announced that it has achieved a significant scientific milestone by publishing three manuscripts in Nature Immunology that advance the understanding of the immune system and highlight underlying mechanisms in two little-understood disease areas -- chronic obstructive pulmonary disease (COPD) and systemic lupus erythematosus (SLE).

26 Apr 2016

Zinc sparks help doctors choose best eggs to transfer during IVF

A stunning explosion of zinc fireworks occurs when a human egg is activated by a sperm enzyme, and the size of these "sparks" is a direct measure of the quality of the egg and its ability to develop into an embryo, according to new research from Northwestern Medicine.

26 Apr 2016

Study reveals how visceral fat contributes to insulin resistance, inflammation

Researchers have long-known that visceral fat - the kind that wraps around the internal organs - is more dangerous than subcutaneous fat that lies just under the skin around the belly, thighs and rear. But how visceral fat contributes to insulin resistance and inflammation has remained unknown.

26 Apr 2016

Light-sensitive serotonin receptors may help study causes of anxiety, depression

Anxiety and depression are two of the most frequently occurring mental disorders worldwide. Light-activated nerve cells may indicate how they are formed.

26 Apr 2016

UK charity Action on Hearing Loss funds new project to develop medicines for hearing loss

Today, UK charity Action on Hearing Loss announces a major investment to fund a new project to develop medicines to treat age-related hearing loss and noise-induced hearing loss at BioTrinity 2016 – Europe’s Leading Investment and Biopartnering Conference.

26 Apr 2016

Hydrocortisone drug can also prevent lung damage in premature babies

Research from Ann & Robert H. Lurie Children's Hospital of Chicago conducted in mice shows the drug hydrocortisone -- a steroid commonly used to treat a variety of inflammatory and allergic conditions -- can also prevent lung damage that often develops in premature babies treated with oxygen.

26 Apr 2016

New photo-switchable molecule for PDT could help treat rapidly growing tumors

Photoswitchable agents might reduce side effects of a chemotherapy. So far, photodynamic therapies have been dependent on oxygen in the tissue. But hardly any oxygen exists in malignant, rapidly growing tumors.

25 Apr 2016

Molecule News and Research

LJI study could provide important target for autoimmune disease interventions

BioAFM Advancements

Mitochondrial dysfunction linked to chemotherapeutic resistance in African-American men with prostate cancer

CMGH study offers insight into future interventions for Crohn's disease, chronic pancreatitis

Predictive statistical approach opens door to development of more effective therapies for breast cancer

University of Kaiserslautern uses JPK NanoWizard AFM to study bacterial interaction with microstructured surfaces

University of Kaiserslautern uses JPK NanoWizard AFM to study bacterial interaction with microstructured surfaces

Experimental therapy has over 90% remission rate for advanced leukemia patients

IPC PAS‘s chemical sensor can rapidly and effectively detect fungal infections

Study reveals surprising results that may impair future therapeutic approaches in TGF-beta pathway

New rat study shows specific genetic factors may contribute to differences in addiction among humans

New fruit fly model study reveals metabolic pathway that can be targeted to treat FXS patients

First small molecule targeted therapy holds promise for Usher syndrome

Newly published manuscripts enhance understanding of the immune system

Zinc sparks help doctors choose best eggs to transfer during IVF

Study reveals how visceral fat contributes to insulin resistance, inflammation

Light-sensitive serotonin receptors may help study causes of anxiety, depression

UK charity Action on Hearing Loss funds new project to develop medicines for hearing loss

Hydrocortisone drug can also prevent lung damage in premature babies

New photo-switchable molecule for PDT could help treat rapidly growing tumors

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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