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Decline in specific protein levels linked to Alzheimer’s disease, not buildup of amyloid plaques

New research from the University of Cincinnati bolsters a hypothesis that Alzheimer's disease is caused by a decline in levels of a specific protein, contrary to a prevailing theory that has been recently called into question.

5 Oct 2022

Omicron reduces host antibody response by lower B-cell antigenicity

A new study explores the functional relevance of some Omicron mutations in terms of their ability to escape neutralizing antibody responses.

4 Oct 2022

Antibody escape mutations of SARS-CoV-2 BA.2.75

A new study discusses how immune escape mutations allow a recent SARS-CoV-2 variant to evade neutralizing antibodies and cause breakthrough infections.

4 Oct 2022

Newly identified mechanism may explain why women are more vulnerable to Alzheimer's disease

Case Western Reserve University researchers have identified a mechanism in brain tissue that may explain why women are more vulnerable to Alzheimer's disease - a finding that they say could help lead to new medicines to treat the disease.

4 Oct 2022

Comparative immunogenicity of COVID-19 vaccines in North California

In new research, researchers evaluated vaccine responses among North Californian residents, including differences in vaccine side effects and antibody (Ab) titers by age, sex, and vaccine type.

4 Oct 2022

Small antiviral molecules termed assembly modulators show therapeutic efficacy against cancer

In a new study, researchers evaluated the anti-cancer therapeutic efficacy of two structurally-unrelated small molecules, PAV-617 and PAV-951.

4 Oct 2022

Multiomic comparison shows a reduction in circulating monocytes correlated with persistent post-COVID-19 pulmonary fibrosis

In a new study, researchers identified distinguishing immune features of coronavirus disease 2019 (COVID-19) in patients with late-resolving pulmonary fibrosis (LR COVID-PF) and early-resolving (ER COVID-PF).

4 Oct 2022

What are the challenges of COVID-19 vaccination and herd immunity?

A new study reviewed the challenges of coronavirus disease 2019 (COVID-19) vaccination and herd immunity.

4 Oct 2022

What are the genetic associations of stroke pathogenesis across ancestry groups?

In new research, researchers identified genetic associations of stroke pathogenesis.

4 Oct 2022

Spike-specific memory B cells develop resilience to SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers explored the cross-reactivity, avidity, and kinetics of memory B-cells and serum antibodies in vaccinated and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals.

4 Oct 2022

How COVID-19 affects the female reproductive system

A new review in the Biology of Reproduction journal analyzed the relationship between the immune system and the female reproductive system while focusing on the effects of COVID-19-associated immune responses on the reproductive system. The study searched PubMed to identify peer-reviewed literature in English up to May 2022 and finally included 83 studies.

3 Oct 2022

Study reveals a promising therapeutic target for spinocerebellar ataxia type 14

Spinocerebellar ataxias are a group of neurodegenerative diseases characterized by the degeneration of Purkinje cells, a major class of neurons in the cerebellum.

3 Oct 2022

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

Stanford University researchers have discovered a rapid and sustainable way to synthetically produce a promising cancer-fighting compound right in the lab.

3 Oct 2022

BU neuroscientists hope to uncover new ways to treat memory-related disorders

You may not realize it, but each time you recall a memory - like your first time riding a bike or walking into your high school prom - your brain changes the memory ever so slightly.

3 Oct 2022

A case for updating COVID vaccines with beta variant spike sequences

A recent Nature Communications study has discussed preclinical and clinical data on COVID-19 vaccine antigens that could be utilized to develop effective booster vaccines.

3 Oct 2022

ASU scientists discover an unusual RNA biogenesis pathway

For the very first time, a study led by Julian Chen and his group in Arizona State University's School of Molecular Sciences and the Biodesign Institute's Center for the Mechanism of Evolution, has discovered an unprecedented pathway producing telomerase RNA from a protein-coding messenger RNA (mRNA).

3 Oct 2022

Study provides new insights into the underlying physiology of mevalonate kinase deficiency

A new study from the Garvan Institute of Medical Research shows how rises in core body temperature may trigger the inflammatory flares in people with a rare genetic autoinflammatory disease.

3 Oct 2022

Social motivator effectively rescues rehab participation in mice after spinal cord injury

A research finding in mice that the drug gabapentin improved rehab compliance after spinal cord injury led scientists to a related, unexpected discovery: Injured mice that didn't receive gabapentin and declined to exercise by themselves were willing to hop on the treadmill when presented with a group rehab option.

3 Oct 2022

Enzyme found to play a crucial role in guiding cellular response to stress

An enzyme called Fic, whose biochemical role was discovered at UT Southwestern more than a dozen years ago, appears to play a crucial part in guiding the cellular response to stress, a new study suggests.

3 Oct 2022

Mount Sinai study suggests significant role of reactive oxygen species in maintaining healthy intestines

Mount Sinai researchers have published one of the first studies to demonstrate the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during wound repair, which could provide greater insights into the prevention and treatment of inflammatory bowel diseases (IBD), according to findings published in the journal Gut on October 3.

3 Oct 2022

Protein C News and Research

Decline in specific protein levels linked to Alzheimer’s disease, not buildup of amyloid plaques

Omicron reduces host antibody response by lower B-cell antigenicity

Antibody escape mutations of SARS-CoV-2 BA.2.75

Newly identified mechanism may explain why women are more vulnerable to Alzheimer's disease

Comparative immunogenicity of COVID-19 vaccines in North California

Small antiviral molecules termed assembly modulators show therapeutic efficacy against cancer

Multiomic comparison shows a reduction in circulating monocytes correlated with persistent post-COVID-19 pulmonary fibrosis

What are the challenges of COVID-19 vaccination and herd immunity?

What are the genetic associations of stroke pathogenesis across ancestry groups?

Spike-specific memory B cells develop resilience to SARS-CoV-2

How COVID-19 affects the female reproductive system

Study reveals a promising therapeutic target for spinocerebellar ataxia type 14

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

BU neuroscientists hope to uncover new ways to treat memory-related disorders

A case for updating COVID vaccines with beta variant spike sequences

ASU scientists discover an unusual RNA biogenesis pathway

Study provides new insights into the underlying physiology of mevalonate kinase deficiency

Social motivator effectively rescues rehab participation in mice after spinal cord injury

Enzyme found to play a crucial role in guiding cellular response to stress

Mount Sinai study suggests significant role of reactive oxygen species in maintaining healthy intestines

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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