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Genes associated with SARS-CoV-2 human lung cell infection

Now, a new study published on the preprint server bioRxiv in June 2020 attempts to make sense of this data to identify viral genes that are explicitly expressed in the cells infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This could help reveal new therapeutic targets.

26 Jun 2020

SARS-CoV-2 has been evolving for at least 7 years

The burning question is how novel viruses acquire the ability to recognize, bind to and enter human cells for the first time – whether this is dependent only on viral proteins recognizing host cell proteins, or adaptations in other viral processes that allow replication in a human host.

25 Jun 2020

Groundbreaking experiment marks first successful delivery of mitochondria to liver cells

University of Connecticut researcher Dr. George Wu recently published a paper in the Journal of Gastroenterology and Hepatology outlining his successful experiment delivering mitochondria to liver cells.

25 Jun 2020

New method spurs production of antibiotic or antiparasitic compounds in actinobacteria

Researchers have developed a method to spur the production of new antibiotic or antiparasitic compounds hiding in the genomes of actinobacteria, which are the source of drugs such as actinomycin and streptomycin and are known to harbor other untapped chemical riches.

25 Jun 2020

Researchers discover receptor that makes mice strong and slim

Increasing abdominal girth and shrinking muscles are two common side effects of aging. Researchers at the University of Bonn have discovered a receptor in mice that regulates both effects.

25 Jun 2020

Pixatimod is active in lab studies against SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) circulating the world has caused over 9.6 million cases and over 490,000 deaths as of June 26, 2020. With neither an effective vaccine nor therapeutic drug yet available, intensive and widespread research is ongoing to develop a pharmacological intervention that will halt the global pandemic.

25 Jun 2020

Study identifies new allergy pathway

Researchers at Johns Hopkins Bloomberg School of Public Health have identified the sequence of molecular events by which tiny, tick-like creatures called house dust mites trigger asthma and allergic rhinitis.

25 Jun 2020

Study assesses impact of anti-SARS-CoV-2 convalescent plasma in COVID-19 disease

The current COVID-19 pandemic is still very much active in most parts of the world. In the absence of effective antiviral drugs or vaccines, scientists are studying the use of blood plasma from convalescent COVID-19 patients, banking on its neutralizing antibody content.

25 Jun 2020

Protein profile in serum reflects COVID-19 severity

The wide range of manifestations of COVID-19 has continued to baffle investigators. Now, a new study published on the preprint server medRxiv in June 2020 shows that blood proteins in COVID-19 patients change over time, and these can possibly predict or reflect the severity of disease. More, they may present targets for treatment.

25 Jun 2020

Immune response variations across the COVID-19 spectrum

A new study published on the preprint server medRxiv in June 2020 describes differences in the adaptive and innate immune response in mild, moderate, and severe COVID-19. This may mean that permanent immune responses occur only in patients who recover from severe COVID-19.

25 Jun 2020

Study identifies world's first genetic and environmental risk factor for common childhood epilepsy

A new study of childhood epilepsy has identified the world's first environmental risk factor for the disease - maternal smoking in pregnancy, and discovered a new genetic association with the condition, pointing to potential new treatments for the disease.

24 Jun 2020

New assay rapidly tests SARS-CoV-2 neutralization and screens antivirals

Researchers at the University of Texas Medical Branch, Galveston, have developed a new platform that can rapidly test neutralizing antibody activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and perform high-throughput screening of potential antiviral agents.

24 Jun 2020

Effective neutralization of SARS-CoV-2 by synthetic nanobodies targeting the spike protein

In their recent bioRxiv paper, a multinational group of researchers reported rapid isolation and characterization of nanobodies from a synthetic library (known as sybodies) that target the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein – with a strikingly high neutralization ability.

24 Jun 2020

ACE inhibition in kidney could influence pathogenesis of SARS-CoV-2

The dynamics of angiotensin-converting enzyme 2 (ACE2) expression in the kidney could have implications for the infectivity and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), say researchers.

24 Jun 2020

Structured 'cut-and-paste' design enables streamlined development of SARS-CoV-2 molecular probes

A seminal study by US researchers, currently available on the bioRxiv* preprint server, demonstrates how structure-based design can be efficiently employed to develop molecular probes targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike and its domains, with possible future use in diagnostics, treatment and vaccine development.

24 Jun 2020

Statin therapy linked to lower death rate in hospitalized patients with COVID-19

The use of cholesterol-lowering drugs called statins is associated with a lower death rate and a lower incidence of mechanical ventilation in patients hospitalized with Coronavirus disease 2019 (COVID-19), researchers report June 24 in Cell Metabolism.

24 Jun 2020

New methods may contribute to future structure-based drug design

Many pharmaceuticals work by targeting what are known as "G-protein-coupled receptors". In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used in new immunotherapy against cancer bind to these receptors.

24 Jun 2020

Abnormal findings in testicular tissue of COVID-19 patients, SARS-CoV-2 mostly undetected

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 9.263 million cases and taken more than 477,000 lives as of June 24, 2020 – just six months after the initial outbreak in Wuhan, China, was reported. The illness, called COVID-19 disease, caused by SARS-CoV-2 is a severe pneumonic illness, caused by the entry of the virus into the type II alveolar cells.

24 Jun 2020

Evidence of link between ACE2 genotype and COVID-19 disease severity

A new study published on the preprint server medRxiv in June 2020 shows that variants in the ACE2 gene which encodes the enzyme receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease, are linked to the risk of severe disease.

24 Jun 2020

Smoking increases risk of COVID-19 for men but not women

Even as the COVID-19 pandemic continues to spread over the world, scientists have had to come to terms with the fact that they don’t know much about the SARS-CoV-2 or the disease it causes. Now, a new study by researchers at the University College Cork, Ireland, and published on the preprint server medRxiv in June 2020 discusses the differences in COVID-19 risk between men and women who smoke.

23 Jun 2020

Receptor News and Research

Genes associated with SARS-CoV-2 human lung cell infection

SARS-CoV-2 has been evolving for at least 7 years

Groundbreaking experiment marks first successful delivery of mitochondria to liver cells

New method spurs production of antibiotic or antiparasitic compounds in actinobacteria

Researchers discover receptor that makes mice strong and slim

Pixatimod is active in lab studies against SARS-CoV-2

Study identifies new allergy pathway

Study assesses impact of anti-SARS-CoV-2 convalescent plasma in COVID-19 disease

Protein profile in serum reflects COVID-19 severity

Immune response variations across the COVID-19 spectrum

Study identifies world's first genetic and environmental risk factor for common childhood epilepsy

New assay rapidly tests SARS-CoV-2 neutralization and screens antivirals

Effective neutralization of SARS-CoV-2 by synthetic nanobodies targeting the spike protein

ACE inhibition in kidney could influence pathogenesis of SARS-CoV-2

Structured 'cut-and-paste' design enables streamlined development of SARS-CoV-2 molecular probes

Statin therapy linked to lower death rate in hospitalized patients with COVID-19

New methods may contribute to future structure-based drug design

Abnormal findings in testicular tissue of COVID-19 patients, SARS-CoV-2 mostly undetected

Evidence of link between ACE2 genotype and COVID-19 disease severity

Smoking increases risk of COVID-19 for men but not women

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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