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EPFL scientists develop new computer model for better design of allosteric drugs

EPFL scientists have created a new computer model that can help better design of allosteric drugs, which control proteins "at a distance".

21 Feb 2017

Penn researchers find new way to track rare T cells in blood after annual flu vaccine

For most vaccines to work the body needs two cell types - B cells and T helper cells - to make antibodies. B cells are the antibody factories and the T helper cells refine the strength and accuracy of antibodies to home and attack their targets.

20 Feb 2017

SLU scientist examines potential biomarkers for pain linked to debilitating health conditions

With new funding from The Mayday Fund, a Saint Louis University researcher will leverage her discovery of a pain pathway to determine if either of two key molecules can be used as biomarkers for pain associated with four debilitating health conditions: chemotherapy-induced peripheral neuropathy, endometriosis, interstitial cystitis and vulvodynia.

16 Feb 2017

Study identifies protein in tumor microenvironment that promotes breast cancer spread

To understand what makes breast cancer spread, researchers are looking at where it lives - not just its original home in the breast but its new home where it settles in other organs. What's happening in that metastatic niche where migrated cancer cells are growing?

16 Feb 2017

New research provides clues to how antibody treatment led to remission in SIV-infected monkeys

Scientists at the National Institutes of Health have found that the presence of the protein alpha-4 beta-7 integrin on the surface of HIV and its monkey equivalent--simian immunodeficiency virus, or SIV--may help explain why an antibody protected monkeys from SIV in previous experiments.

16 Feb 2017

Mice study shows how WAVE1 protein regulates the brain's response to cocaine

Cocaine is one of the most addictive substances known to man, and for good reason: By acting on levels of the "feel-good" chemical dopamine, it produces a tremendous sensation of euphoria.

15 Feb 2017

Two-drug combination shows promise against diabetic retinopathy in animal models

A two-drug cocktail provided better protection against diabetes-related vision loss than a single drug during testing in rat models, a team of University of Florida Health and Dutch researchers has found.

15 Feb 2017

Researchers pinpoint new neural mechanism that regulates chronic stress response

In addition to the classic stress response in our bodies - an acute reaction that gradually abates when the threat passes - our bodies appear to have a separate mechanism that deals only with chronic stress.

15 Feb 2017

Only subset of mother's HIV virus infects infants during pregnancy or breastfeeding, research shows

In the transmission of HIV-1 from mother to child only a subset of a mother's viruses infects their infants either in utero or via breastfeeding, and the viruses that are transmitted depend on whether transmission occurs during pregnancy or through breastfeeding, according to UCLA-led research.

15 Feb 2017

Research opens treatment pathways for cancers that do not respond to targeted antibodies

By hijacking a cancer cell's own metabolism, researchers have found a way to tag and target elusive cancers with small-molecule sugars. This opens treatment pathways for cancers that are not responsive to conventional targeted antibodies, such as triple-negative breast cancer.

15 Feb 2017

Researchers explore role played by nicotine in grouping of nicotinic receptors within the brain

Nicotine -- the primary compound found within tobacco smoke -- is known to change the grouping of some subtypes of nicotinic receptors, but the mechanisms for nicotine addiction remain unclear.

15 Feb 2017

New infusion therapy may help avoid debilitating symptoms in Parkinson's disease patients

Constant infusion of a drug now used intermittently to "rescue" patients with Parkinson's from bouts of immobility may also help avoid these debilitating symptoms and smooth out their movement throughout the day, physician-scientists say.

14 Feb 2017

Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

A father's nicotine use may have a significant impact on children's risk of some diseases. In a study published in the online biomedical sciences journal eLife, Oliver J. Rando, MD, PhD, and colleagues at UMass Medical School, demonstrate that mice born of fathers who are habitually exposed to nicotine inherit enhanced chemical tolerance and drug clearance abilities.

14 Feb 2017

New RNAi treatment safely blocks ocular inflammation in mice

Scientists have developed a new RNA interference therapeutic agent that safely blocked ocular inflammation in mice, potentially making it a new treatment for human uveitis and diabetic retinopathy.

14 Feb 2017

TSRI scientists describe how key molecules in the brain work together to trigger intense anxiety

In a new study, researchers at The Scripps Research Institute have described how two important molecules in the brain work together to trigger intense anxiety.

13 Feb 2017

New study reveals potential drug to combat life-threatening effects of COPD

New research published online in The FASEB Journal reveals a potential drug to combat the life-threatening effects of chronic obstructive pulmonary disease (COPD).

13 Feb 2017

Scientists identify new biomarkers that could guide bowel cancer treatment

Colorectal carcinomas arise in different forms, so all treatments do not work for all patients. OncoTrack, a public-private consortium supported by the Innovative Medicines Initiative Joint Undertaking, has conducted one of Europe's largest collaborative academic-industry research projects to develop and assess novel approaches for identification of new markers for colon cancer.

13 Feb 2017

New discovery could lead to more effective malaria vaccine

A team at the Wellcome Trust Sanger Institute has discovered how a promising malarial vaccine target - the protein RH5 - helps parasites to invade human red blood cells.

11 Feb 2017

Malaria mosquitoes exhibit similar sensitivity to heat and horseradish

Researchers at Lund University in Sweden have taken an important step on the road to understanding the underlying mechanism of how and why animals can feel pain in connection with cold or heat. However, according to the study, temperature is just one triggering factor – horseradish, mustard, cinnamon and wasabi have a similar effect.

10 Feb 2017

Scientists identify gene variants that predispose children to developing Kawasaki disease

Kawasaki disease (KD) is the most common acquired heart disease in children. Untreated, roughly one-quarter of children with KD develop coronary artery aneurysms -- balloon-like bulges of heart vessels -- that may ultimately result in heart attacks, congestive heart failure or sudden death.

9 Feb 2017

Receptor News and Research

EPFL scientists develop new computer model for better design of allosteric drugs

Penn researchers find new way to track rare T cells in blood after annual flu vaccine

SLU scientist examines potential biomarkers for pain linked to debilitating health conditions

Study identifies protein in tumor microenvironment that promotes breast cancer spread

New research provides clues to how antibody treatment led to remission in SIV-infected monkeys

Mice study shows how WAVE1 protein regulates the brain's response to cocaine

Two-drug combination shows promise against diabetic retinopathy in animal models

Researchers pinpoint new neural mechanism that regulates chronic stress response

Only subset of mother's HIV virus infects infants during pregnancy or breastfeeding, research shows

Research opens treatment pathways for cancers that do not respond to targeted antibodies

Researchers explore role played by nicotine in grouping of nicotinic receptors within the brain

New infusion therapy may help avoid debilitating symptoms in Parkinson's disease patients

Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

New RNAi treatment safely blocks ocular inflammation in mice

TSRI scientists describe how key molecules in the brain work together to trigger intense anxiety

New study reveals potential drug to combat life-threatening effects of COPD

Scientists identify new biomarkers that could guide bowel cancer treatment

New discovery could lead to more effective malaria vaccine

Malaria mosquitoes exhibit similar sensitivity to heat and horseradish

Scientists identify gene variants that predispose children to developing Kawasaki disease

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