Clinical Trial News and Research

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Insilico Medicine develops new deep-learning based hematological human aging clock

Today, Insilico Medicine, Inc., a Baltimore-based company specializing in the application of artificial intelligence for drug discovery, biomarker development and aging research, announced a publication of a research paper titled "Population-specific biomarkers of human aging: a big data study using South Korean, Canadian and Eastern-European patient populations" in The Journal of Gerontology.

11 Jan 2018

CAP releases new guideline for HPV testing in patients with head and neck cancers

Certain head and neck cancers that are positive for high-risk types of human papillomavirus (HPV) have a better prognosis and may need less aggressive treatment.

11 Jan 2018

Clinical study investigates lifestyle biomarkers in prostate cancer survivors

Advanced glycation end products, which have been linked to many chronic diseases, including diabetes, cardiovascular disease and cancer, build up in the body from birth due to normal metabolism but are often higher in those eating the high-fat, high-sugar, highly processed foods characteristic of the Western diet.

11 Jan 2018

Scientists use artificial intelligence to create new ‘ImmunoMap’

Johns Hopkins scientists have used a form of artificial intelligence to create a map that compares types of cellular receptors, the chemical "antennas" on the surface of immune system T-cells.

8 Jan 2018

Beta blockers may improve survival for melanoma patients

A common, inexpensive drug that is used to prevent heart attacks and lower blood pressure may also help melanoma patients live longer, according to researchers.

8 Jan 2018

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced a collaboration for the development of a potential gene therapy using zinc finger protein transcription factors (ZFP-TFs) to treat amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to mutations of the C9ORF72 gene.

8 Jan 2018

HSS researchers win grant to determine if stem cell therapy can improve outcomes for rotator cuff tears

A multidisciplinary team led by Scott Rodeo, MD, and Christopher Mendias, PhD, at Hospital for Special Surgery has been awarded the Orthopaedic Research and Education Foundation Clinical Research Grant in Cellular Therapy in honor of James Urbaniak, MD in Collaboration with National Stem Cell Foundation.

5 Jan 2018

Experimental device could help ease tinnitus symptoms by targeting unruly nerve activity in the brain

Millions of Americans hear ringing in their ears -- a condition called tinnitus -- but a new study shows an experimental device could help quiet the phantom sounds by targeting unruly nerve activity in the brain.

5 Jan 2018

Study suggests vitamin C enhances tuberculosis drugs effectiveness

A new study conducted by researchers at the Albert Einstein College of Medicine, Bronx, NY, proposed the use of vitamin C together with tuberculosis drugs for rapid eradication of the disease-causing pathogens. The studies were carried out on mice and in tissue cultures and the results have been published in the journal of American Society for Microbiology, Antimicrobial Agents and Chemotherapy.

5 Jan 2018

Specific bacteria in the intestines can improve response rate to cancer immunotherapy

In the Jan. 5, 2018 issue of Science, researchers from the University of Chicago Medicine show that specific strains of commensal bacteria – the swarms of microorganisms naturally dwelling in the intestines – can improve the response rate to immunotherapy for patients being treated for advanced melanoma.

5 Jan 2018

Researchers discover genetic mechanism for resistance to immunotherapy drugs

An urgent question for cancer scientists is why immunotherapy achieves dramatic results in some cases but doesn't help most patients.

5 Jan 2018

Phase III clinical study of regenerative therapy for treating damaged cartilage has started

A group of researchers at Osaka University developed a synthetic tissue using synovium-derived mesenchymal stem cells (MSCs) for treating damaged cartilage, which had previously been incurable and had no effective therapies.

4 Jan 2018

Scientists develop promising new approach to tinnitus treatment

An experimental device that delivers precisely timed signals to target nerve activity in the brain could help ease the symptoms of tinnitus.

4 Jan 2018

Generic skin cream may reduce squamous cell carcinoma risk

New results from a clinical trial involving more than 900 military veterans at high risk for keratinocyte carcinoma skin cancer provides evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk of a squamous cell carcinoma (SCC) needing surgery by 75 percent within a year.

3 Jan 2018

TriNetX reveals Natural Language Processing to Better Identify Patients for Clinical Trials

TriNetX, the global health research network for healthcare organizations, biopharmaceutical companies, and Contract Research Organizations (CROs), today announced the general availability of its Natural Language Processing (NLP) service.

3 Jan 2018

Rutgers researcher receives $1 million grant for international prostate cancer study

A $1 million grant from Gateway for Cancer Research will help Rutgers Cancer Institute of New Jersey Urologic Oncology Chief Isaac Yi Kim, MD, PhD, MBA evaluate the impact of surgically removing the prostate in men with metastatic prostate cancer in the United States and Asia.

2 Jan 2018

Experts report new guidelines for clinical trial design in patients with brain metastases

Clinical trials of new anti-cancer therapies have often excluded patients whose disease has spread to the brain or central nervous system (CNS) or, if such patients were allowed on trial, trials have often failed to clearly capture information on the drug's effect in the brain.

30 Dec 2017

$Study uncovers genomic targets in refractory neuroblastoma$

Study uncovers genomic targets in refractory neuroblastoma

Neuroblastoma (NB) is the most common solid tumor found in children. It starts in some very early forms of nerve cells found in the embryo or fetus.

28 Dec 2017

Nanobiotix receives FDA approval for first immuno-oncology trial

NANOBIOTIX, a late clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the U.S. Food and Drug Administration has approved its Investigational New Drug Application for NBTXR3, a first-in-class nanoparticle designed for direct injection into cancerous tumors, activated by stereotactic ablative radiotherapy (SABR) and administered in combination with an anti-PD1 antibody (nivolumab or pembrolizumab).

26 Dec 2017

Novartis announces FDA approval of its first and only CML therapy with TFR data in product label

Novartis announced today that the US Food and Drug Administration (FDA) approved the inclusion of Treatment-free Remission (TFR) data in the Tasigna® (nilotinib) US product label.

26 Dec 2017

Clinical Trial News and Research

Insilico Medicine develops new deep-learning based hematological human aging clock

CAP releases new guideline for HPV testing in patients with head and neck cancers

Clinical study investigates lifestyle biomarkers in prostate cancer survivors

Scientists use artificial intelligence to create new ‘ImmunoMap’

Beta blockers may improve survival for melanoma patients

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

HSS researchers win grant to determine if stem cell therapy can improve outcomes for rotator cuff tears

Experimental device could help ease tinnitus symptoms by targeting unruly nerve activity in the brain

Study suggests vitamin C enhances tuberculosis drugs effectiveness

Specific bacteria in the intestines can improve response rate to cancer immunotherapy

Researchers discover genetic mechanism for resistance to immunotherapy drugs

Phase III clinical study of regenerative therapy for treating damaged cartilage has started

Scientists develop promising new approach to tinnitus treatment

Generic skin cream may reduce squamous cell carcinoma risk

TriNetX reveals Natural Language Processing to Better Identify Patients for Clinical Trials

Rutgers researcher receives $1 million grant for international prostate cancer study

Experts report new guidelines for clinical trial design in patients with brain metastases

Study uncovers genomic targets in refractory neuroblastoma

Nanobiotix receives FDA approval for first immuno-oncology trial

Novartis announces FDA approval of its first and only CML therapy with TFR data in product label

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