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TSRI scientists develop new process to synthesize naturally occurring compound phorbol

In a landmark feat of chemical synthesis, scientists at The Scripps Research Institute have developed a 19-step process for making the naturally occurring compound phorbol in the laboratory, in quantities that are useful for pharmaceutical research.

24 Mar 2016

Novel mechanism can suppress blood vessel leakage, reduce tumour spread in mice

Cancer therapy is often hampered by the accumulation of fluids in and around the tumour, which is caused by leakage from the blood vessels in the tumour. Researchers at Uppsala University now show how leakage from blood vessels is regulated.

24 Mar 2016

Scientists provide overview of most promising compounds to combat prostate cancer

Scientists from MIPT (Moscow Institute of Physics and Technology), MSU (Moscow State University), and National University of Science and Technology “MISIS” provided an overview of the most promising compounds which can be used as medications for prostate cancer.

23 Mar 2016

Healthy brain metabolism communicates with fluid intelligence in young adults

A healthy brain is critical to a person's cognitive abilities, but measuring brain health can be a complicated endeavor. A new study by University of Illinois researchers reports that healthy brain metabolism corresponds with fluid intelligence - a measure of one's ability to solve unusual or complex problems - in young adults.

23 Mar 2016

Targeted therapies suppress T cell activity that could actually help fight tumors

In many cases, targeted therapies for cancer are preferred as treatments over chemotherapy and surgery because they attack and kill cancer cells with specific tumor-promoting mutations while sparing healthy, normal cells that do not express these mutations.

23 Mar 2016

University of Copenhagen researchers discover Achilles heel of bacteria

Drug resistant bacteria are fast becoming one of the big worries of the 21 century. Now researchers at the University of Copenhagen have discovered a previously unknown weakness; an "Achilles heel", of bacteria. Their discovery, a crucial step in bacteria's energy metabolism, may be the first step in developing an entirely novel form of antibiotics

22 Mar 2016

Key molecule in breast, lung cancer cells can help prevent spread of cancer

Scientists have revealed that a key molecule in breast and lung cancer cells can help switch off the cancers' ability to spread around the body.

22 Mar 2016

UGA investigators find viable treatment for prostate cancer

Researchers at the University of Georgia have created a new therapeutic for prostate cancer that has shown great efficacy in mouse models of the disease. They published their findings recently in the journal Nanomedicine: Nanotechnology, Biology and Medicine.

22 Mar 2016

Aging-associated changes begin earlier than expected in human brain

A new study published in Physiological Genomics suggests that the brain shows signs of aging earlier than old age. The study found that the microglia cells—the immune cells of the brain—in middle-aged mice already showed altered activity seen in microglia from older mice.

21 Mar 2016

Study: Cox2 inhibition improves outcomes in preeclampsia-like mouse model

Preeclampsia is characterized by elevated blood pressure in the second half of pregnancy and impaired blood flow to the placenta, which increases the risk of premature birth and pregnancy complications.

21 Mar 2016

Novel compound shows promise as potential treatment for acute myeloid leukemia

A novel compound has shown promise in preclinical studies as a treatment for acute myeloid leukemia, more than doubling median days of survival even in a drug-resistant form of the disease.

21 Mar 2016

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

A common theme in medicine is that detecting a disease early on can lead to more effective treatments. This relies partly on luck that the patient gets screened at the right time, but more important is that the testing techniques are sensitive enough to register the minuscule hints that diseases leave in the blood stream.

21 Mar 2016

New type of nerve cells appears to control feeding behaviors in mice

While researching the brain's learning and memory system, scientists at Johns Hopkins say they stumbled upon a new type of nerve cell that seems to control feeding behaviors in mice. The finding, they report, adds significant detail to the way brains tell animals when to stop eating and, if confirmed in humans, could lead to new tools for fighting obesity. Details of the study will be published by the journal Science on March 18.

20 Mar 2016

Novel plasmid-based microRNA inhibitor system effectively prevents microRNA activity in cells

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Brad Amendt, University of Iowa, Iowa City, USA, will present a study titled "New Biotechnology to Inhibit MicroRNA Activity and Novel Applications for Craniofacial and Dental Research."

19 Mar 2016

Manipulation of NAD could lead to potential therapy for acute kidney injury

Approximately one out of five hospitalized adults and one out of three hospitalized children worldwide experience acute kidney injury, the sudden loss of kidney function. Many different factors, including surgery, chemotherapy or shock, can lead to acute kidney injury, but exactly why the kidneys are so vulnerable to these and other stressors has not been well understood.

19 Mar 2016

UC San Diego researchers use CRISPR-Cas9 system to target RNA in living cells for first time ever

The genetic code stored in DNA determines everything from the color of our eyes to our susceptibility to disease. This has motivated scientists to sequence the human genome and develop ways to alter the genetic code, but many diseases are linked to a different fundamental molecule: RNA.

18 Mar 2016

BioAgilytix announces acquisition of IPM Biotech

BioAgilytix, a leading provider of contract bioanalytical testing services specializing in large molecule bioanalysis, has announced the acquisition of IPM Biotech, a German-based bioanalytical contract research laboratory renowned for its expertise in large molecule bioanalysis, particularly in the area of immunogenicity.

18 Mar 2016

Inhibiting cholesterol esterification can potentiate antitumor activity of killer T cells

As key players in the immune system, T cells provide tumor surveillance and have direct antitumor effects. However, tumors can escape T-cell attack through various mechanisms in the tumor microenvironment. Reactivating the antitumor effects of T cells has shown great clinical benefits in treating various cancers.

18 Mar 2016

Global improvement in antioxidant capacity may delay ageing

The gradual accumulation of cell damage plays a very important role in the origin of ageing. There are many sources of cellular damage, however, which ones are really responsible for ageing and which ones are inconsequential for ageing is a question that still lacks an answer

17 Mar 2016

Could prebiotics benefit early life brain development? An interview with Dr Phil Burnet

Galacto-oligosaccharides are essentially sugar or saccharide molecules that have been joined together into short polymer chains.

16 Mar 2016

Molecule News and Research

TSRI scientists develop new process to synthesize naturally occurring compound phorbol

Novel mechanism can suppress blood vessel leakage, reduce tumour spread in mice

Scientists provide overview of most promising compounds to combat prostate cancer

Healthy brain metabolism communicates with fluid intelligence in young adults

Targeted therapies suppress T cell activity that could actually help fight tumors

University of Copenhagen researchers discover Achilles heel of bacteria

Key molecule in breast, lung cancer cells can help prevent spread of cancer

UGA investigators find viable treatment for prostate cancer

Aging-associated changes begin earlier than expected in human brain

Study: Cox2 inhibition improves outcomes in preeclampsia-like mouse model

Novel compound shows promise as potential treatment for acute myeloid leukemia

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

New type of nerve cells appears to control feeding behaviors in mice

Novel plasmid-based microRNA inhibitor system effectively prevents microRNA activity in cells

Manipulation of NAD could lead to potential therapy for acute kidney injury

UC San Diego researchers use CRISPR-Cas9 system to target RNA in living cells for first time ever

BioAgilytix announces acquisition of IPM Biotech

Inhibiting cholesterol esterification can potentiate antitumor activity of killer T cells

Global improvement in antioxidant capacity may delay ageing

Could prebiotics benefit early life brain development? An interview with Dr Phil Burnet

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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