Therapy News and Research

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Novel T cell receptor therapy shows early promise for treating solid tumors

Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), an adoptive T cell receptor (TCR) therapy targeting the MAGE-A4 cancer antigen, achieved clinically significant results for patients with multiple solid tumor types in a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

9 Jan 2023

Newly identified gene drives development of the second most common type of lung carcinoma

A team led by researchers at NYU Langone Health's Perlmutter Cancer Center has identified a gene that drives development of the second most common type of lung carcinoma, offering greater insight into how the disease might someday be treated.

9 Jan 2023

Review focuses on the link between the pathogenesis and management of hepatocellular carcinoma

A new review was published in Genes & Cancer on December 13, 2022, entitled, "Pathogenesis to management of hepatocellular carcinoma."

9 Jan 2023

Study suggests air pollution is an important independent risk factor for asthma exacerbations in children living in urban areas

A new study reported that moderate levels of outdoor air pollutants, ozone, and fine particulate matter correlated to non-viral asthma attacks in children and adolescents who live in low-income urban areas.

9 Jan 2023

Researchers discover a highly potent biomarker for clinical response to CAR-T cell therapy

A MedUni Vienna research team has discovered a highly potent biomarker for clinical response to CAR-T cell therapy, describing the prerequisites for optimal use of this novel therapy for lymphoma treatment.

9 Jan 2023

UCD HealthTech spin-out raises €525,000 to launch a 12-month weight management program

Beyondbmi, a University College Dublin (UCD) HealthTech spin-out company supported by NovaUCD, has announced closing a €525,000 pre-seed funding round, advised by CKS Finance.

9 Jan 2023

The attitudes of women with a new diagnosis of gestational diabetes to the required lifestyle changes

A recent study evaluated the attitudes of women newly diagnosed with GDM towards the required lifestyle changes, particularly regarding diet and exercise.

9 Jan 2023

Clinically relevant biomarker strategies in drug development

In this interview, NewsMedical speaks with Dr. Justin Devine and Dr. Nicholas Woudberg about biomarkers, their importance for drug development as well as the potential they have when it comes to machine learning.

From Synexa Life Sciences 9 Jan 2023

Research suggests people on rheumatoid arthritis drugs show weaker response to SARS-CoV-2 vaccines

Researchers conducted a comparative study among a cohort of individuals on rheumatoid arthritis (RA) therapies vis-à-vis healthy controls to assess their responses to coronavirus disease 2019 (COVID-19) vaccines.

9 Jan 2023

Study: Almost a third of patients with chronic pain use cannabis

As more U.S. states legalize cannabis (also known as marijuana) for medical and recreational use, increasing numbers of people are experimenting with it for pain relief. According to a new study published in JAMA Network Open, almost a third of patients with chronic pain reported using cannabis to manage it.

6 Jan 2023

'Family Expectations' program benefits expectant parents

The birth of a child is a major life transition, and it can be a stressful time for new parents. Family and relationship education programs are available to help individuals and couples deal with these challenges. But do such programs work as intended?

6 Jan 2023

New research on DNA-repair enzyme could help enhance cancer drug development

Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, took a close look at one of ways cells repair broken strands of DNA and discovered details that could help make a particular enzyme a promising target for precision cancer therapy.

6 Jan 2023

PSMA PET/MRI can successfully determine the risk of prostate cancer recurrence

In men recently diagnosed with intermediate or high-grade prostate cancer, prostate specific membrane antigen (PSMA) PET/MRI can successfully determine whether their cancer is likely to return within two years of a prostatectomy.

6 Jan 2023

Researchers show how liver cancer cells hijack circadian clock machinery to divide and spread

The most common type of liver cancer, hepatocellular carcinoma (HCC), is already the third leading cause of cancer-related deaths globally - and cases are on the rise, both in the U.S. and worldwide.

6 Jan 2023

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

A new research paper was published in Oncotarget's Volume 13 on December 20, 2022, entitled, "Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression."

6 Jan 2023

High affinity antibodies isolated to safely target Claudin 6-positive tumors

Integral Molecular, the industry leader in antibody discovery for membrane proteins, has published the targeting mechanism enabling best-in-class specificity of its Claudin 6 (CLDN6) antibody CTIM-76 being developed for cancer therapy with Context Therapeutics.

6 Jan 2023

Brief tele-cognitive behavioral therapy for head and neck cancer survivors with body-image distress shows promising results

Talking, smiling, eating together – these are all social activities that are inherent to the human experience. But for some head and neck cancer survivors, they are dreaded tasks.

6 Jan 2023

Study links epigenetic biological aging and aberrations in neural oscillatory activity in people with HIV

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 24, entitled, "Epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV."

6 Jan 2023

Is appropriate initial empirical antimicrobial therapy associated with lower in-hospital mortality in patients with bloodstream infections?

Researchers estimated the association between the receipt of appropriate initial empirical antibiotic treatment and in-hospital death among individuals hospitalized with BSI (bloodstream infections).

6 Jan 2023

Study describes the variations in drug response across genetic subtypes of childhood leukemia

Scientists at St. Jude Children's Research Hospital are reporting the most comprehensive study to date describing the variations in drug response across different genetic subtypes of acute lymphoblastic leukemia (ALL).

5 Jan 2023

Therapy News and Research

Novel T cell receptor therapy shows early promise for treating solid tumors

Newly identified gene drives development of the second most common type of lung carcinoma

Review focuses on the link between the pathogenesis and management of hepatocellular carcinoma

Study suggests air pollution is an important independent risk factor for asthma exacerbations in children living in urban areas

Researchers discover a highly potent biomarker for clinical response to CAR-T cell therapy

UCD HealthTech spin-out raises €525,000 to launch a 12-month weight management program

The attitudes of women with a new diagnosis of gestational diabetes to the required lifestyle changes

Clinically relevant biomarker strategies in drug development

Research suggests people on rheumatoid arthritis drugs show weaker response to SARS-CoV-2 vaccines

Study: Almost a third of patients with chronic pain use cannabis

'Family Expectations' program benefits expectant parents

New research on DNA-repair enzyme could help enhance cancer drug development

PSMA PET/MRI can successfully determine the risk of prostate cancer recurrence

Researchers show how liver cancer cells hijack circadian clock machinery to divide and spread

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

High affinity antibodies isolated to safely target Claudin 6-positive tumors

Brief tele-cognitive behavioral therapy for head and neck cancer survivors with body-image distress shows promising results

Study links epigenetic biological aging and aberrations in neural oscillatory activity in people with HIV

Is appropriate initial empirical antimicrobial therapy associated with lower in-hospital mortality in patients with bloodstream infections?

Study describes the variations in drug response across genetic subtypes of childhood leukemia

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