Cholesterol News and Research

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Cholesterol is a waxy, fat-like substance made in the liver, and found in the blood and in all cells of the body. Cholesterol is important for good health and is needed for making cell walls, tissues, hormones, vitamin D, and bile acid.

Concern raised again about heart drugs Zetia and Vytorin

The editors of the New England Journal of Medicine have raised concern regarding the cholesterol-lowering drugs Zetia and Vytorin.

3 Sep 2008

Millions face undiagnosed heart risk in the UK say researchers after mass screening

One in three people with a high risk of developing cardiovascular disease (CVD) over the next 10 years have not been diagnosed, according to a major study in the September issue of IJCP, the International Journal of Clinical Practice.

2 Sep 2008

The effects of A2 inhibitor Darapladib on human coronary athlerosclerotic plaque

A twelve month study of treatment with darapladib concluded that,Lp-PLA2 inhibition with darapladib prevented necrotic core expansion, a key determinant of plaque vulnerability.

2 Sep 2008

Overcoming poor response to standard oral antiplatelet agents

Existing practice surrounding many cardiovascular medications, including anti-hypertensive and lipid-lowering agents, is based on the evaluation of response to therapy. In cases where ideal therapeutic targets (which have been identified through several previous studies) are not met in the single individual, there is evidence to support the need to intensify standard treatment so as to achieve better control of the cardiovascular risk factor under treatment (e.g. blood pressure or cholesterol levels) as this translates into a better outcome.

2 Sep 2008

Results from the Simvastatin and Ezetimibe in aortic stenosis study

The SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) study has investigated the effects of intensive cholesterol lowering with the combination of simvastatin (40 mg daily) and ezetimibe (10 mg daily) in patients with aortic stenosis.

2 Sep 2008

Intima media thickness of the carotid artery

Both in the clinic and in the research area we look for a toll to identify subjects who will develop cardiovascular disease. Decades of silent arterial wall alterations precede vascular clinical events, which then reflect advanced atherosclerotic disease.

1 Sep 2008

Save your life by taking the stairs instead of the lift

Researchers say walking up the stairs at work instead of taking the lift could be a lifesaver.

1 Sep 2008

Sex hormones link to heart risk

Men are more prone to - and likely to die of - heart disease compared with women of a similar age - and sex hormones are to blame, according to a new University of Leicester led study.

1 Sep 2008

Issues on cholesterol: diet, statins and genetics

Genetic lipoprotein disorders are frequently seen in patients with premature coronary artery disease (CAD). An example of strong genetic predisposition is the disorder: familial hypercholesterolemia, where a single gene defect (the low density lipoprotein receptor) contributes to most of the familial expression of CAD.

1 Sep 2008

Primary prevention of coronary heart disease: challenges and achievements

The European Society of Cardiology together with other partner Societies has engaged in a comprehensive programme of prevention of cardiovascular disease (CVD) since 1994. Guidelines on this important topic have been developed and updated at regular intervals over the last 13 years, most recently in 2007.

1 Sep 2008

Thiazolidinediones - diabetes drugs carry significant cardiovascular risks

A class of oral drugs used to treat type 2 diabetes may significantly increase the risk of serious cardiovascular events, according to an editorial published online in Heart Wednesday by two Wake Forest University School of Medicine faculty members.

28 Aug 2008

Alabama board approves plan to charge state employees for obesity, health problems

The Alabama State Employees' Insurance Board last week approved a plan that will require state employees who are obese or have health problems to make progress to address those issues or pay a monthly charge for health insurance, the AP/Philadelphia Inquirer reports.

26 Aug 2008

New York Health Department to decide soon whether Medicaid beneficiaries with HIV/AIDS should be moved into managed care plans

The New York State Department of Health in the next few weeks is expected to issue a final decision on whether to switch Medicaid beneficiaries with HIV/AIDS from fee-for-service plans to managed care plans, the AP/Long Island Newsday reports (AP/Long Island Newsday, 8/24).

26 Aug 2008

High cholesterol levels drop naturally in children on high-fat antiseizure diet

Elevated cholesterol levels return to normal or near normal levels over time in four out of 10 children with uncontrollable epilepsy treated with the high-fat ketogenic diet, according to results of a Johns Hopkins Children's Center study reported in the Journal of Child Neurology.

26 Aug 2008

Olive leaf extract (EFLA943) helps tackle high blood pressure and cholesterol

Taking 1000mg of a specific olive leaf extract (EFLA943) can lower cholesterol and lower blood pressure in patients with mild hypertension (high blood pressure).

26 Aug 2008

Study reveals how blood flow force protects against atherosclerosis

Machines on cell surfaces, mechanical and lifeless as bed springs, protect blood vessels by responding to blood flow force, according to research published today in the Journal of Cell Biology. By sensing and reacting to force, such machines interfere with inflammatory pathways central to atherosclerosis, the cause of clogged arteries that lead to heart attack and stroke, the authors said. The next set of studies, already underway, seeks to "tweak" the process with the goal of designing a new class of therapies.

25 Aug 2008