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Researchers reveal mechanisms involved in development of metabolic complications linked to obesity

Metabolic complications of obesity and overweight, such as type 2 diabetes, are an important challenge to public health. Teams led by Nicolas Venteclef, Inserm Research Fellow (Cordeliers Research Centre, Inserm/Pierre and Marie Curie University Joint Research Unit 1138, Paris, France) and Irina Udalova (Kennedy Institute of Rheumatology, University of Oxford, UK) in collaboration with several teams, have succeeded in elucidating part of the mechanisms involved in the development of these metabolic complications associated with obesity.

8 May 2015

Omega-3 fatty acids in fish oil can restore nerves damaged from diabetes

Approximately 50 percent of patients with diabetes suffer from nerve damage, or neuropathy. No cure exists, and the most effective treatment, keeping blood sugar in control, only slows neuropathy.

7 May 2015

Hepatitis C common among HIV-positive patients in sub-Saharan Africa

A new study has found high levels of infection with hepatitis C (HCV) across Africa, particularly in people infected with HIV...

7 May 2015

Investigational three-drug combination clears hepatitis C in 93% of patients with liver cirrhosis

A 12-week dose of an investigational three-drug hepatitis C combination cleared the virus in 93 percent of patients with liver cirrhosis who hadn't previously been treated, according to a study in the May 5, 2015, issue of The Journal of the American Medical Association.

7 May 2015

Compact Light Source generates X-ray imaging suitable for advanced computer tomography

A new study shows that the recently developed Compact Light Source (CLS) - a commercial X-ray source with roots in research and development efforts at the Department of Energy's SLAC National Accelerator Laboratory - enables computer tomography scans that reveal more detail than routine scans performed at hospitals today.

7 May 2015

LaVision BioTec reports on the research work of the Milan-based Iannacone Laboratory to study virus responses using intravital microscopy

LaVison BioTec, developers of advanced microscopy solutions for the life sciences, report on the research of Dr Matteo Iannacone of the San Raffaele Scientific Institute in Milan where intravital microscopy is being applied to the study of host-viruses and associated immune responses.

7 May 2015

Scientists identify mechanism that explains how some stem cells get new identity

Scientists at the University of Copenhagen have identified one mechanism that explains how some stem cells choose to become a given cell type: the cells combine specific sets of proteins at precise positions along the DNA. When these particular groups of proteins are combined, the gates are opened so that certain groups of genes can now be used, giving the cells a new identity.

6 May 2015

Exalenz Bioscience investigates clinical utility of BreathID test to diagnose NASH

Exalenz Bioscience, a leader in developing and marketing of non-invasive medical devices for diagnosing and monitoring a range of gastrointestinal and liver diseases, today announced the initiation of a clinical study evaluating the potential of its BreathID test to diagnose nonalcoholic steatohepatitis (NASH).

6 May 2015

Study sheds light on long-hidden link between chronic high blood sugar and disruption of mitochondria

Scientists at Johns Hopkins say they've discovered a cause-and-effect link between chronic high blood sugar and disruption of mitochondria, the powerhouses that create the metabolic energy that runs living cells. The discovery, reported online in Proceedings of the National Academy of Sciences on April 27, sheds light on a long-hidden connection and, they say, could eventually lead to new ways of preventing and treating diabetes.

6 May 2015

New study finds high levels of HCV infection among HIV-infected people across Africa

A new study has found high levels of infection with hepatitis C (HCV) across Africa, particularly in people infected with HIV.

6 May 2015

LaVision BioTec reports on the research work of the Milan-based Iannacone Laboratory to study virus responses using intravital microscopy

5 May 2015

New study identifies enzyme that causes obesity-related hypertension

Obesity is a serious health problem affecting approximately one-third of the adult population in the United States. Obese individuals have an increased risk of diabetes and cardiovascular disease, including hypertension. A recent study led by a University of Missouri researcher has identified the enzyme responsible for obesity-related hypertension -- a finding that could lead to new treatment options.

5 May 2015

Pancreatic cancer rates higher in countries with less sunlight

Writing in the April 30 online issue of the Journal of Steroid Biochemistry and Molecular Biology, researchers at University of California San Diego School of Medicine report pancreatic cancer rates are highest in countries with the least amount of sunlight. Low sunlight levels were due to a combination of heavy cloud cover and high latitude.

30 Apr 2015

Dr. Philipp Scherer to receive prestigious Banting Medal for Scientific Achievement from ADA

Dr. Philipp Scherer, Director of the Touchstone Center for Diabetes Research at UT Southwestern Medical Center, will receive the prestigious Banting Medal for Scientific Achievement, the highest honor bestowed by the American Diabetes Association.

30 Apr 2015

Fifth patient dosed in Benitec's TT-034 Phase I/IIa clinical trial for prevention of HCV infection

Benitec Biopharma, a biopharmaceutical company focused on providing potentially curative therapies with its proprietary gene-silencing technology called ddRNAi or "expressed RNAi," is pleased to advise that the fifth patient in the company's 'first in man', Phase I/IIa dose escalation clinical trial of TT-034 for hepatitis C virus (HCV) infection, has today, been dosed at the Duke Clinical Research Unit.

29 Apr 2015

New study finds that sexual function in adult living donors lower at three months after transplant

A new study found that sexual function in adult living donors was lower at the evaluation phase and at three months following liver transplantation. Results published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, suggest that donor education prior to surgery may improve recovery and ease concerns about sexual function following the transplant.

29 Apr 2015

Researchers pinpoint new mechanism responsible for malaria progression

A team of researchers from four universities has pinpointed one of the mechanisms responsible for the progression of malaria, providing a new target for possible treatments.

28 Apr 2015

Will new hepatitis C treatments strain payers’ budgets? An interview with Dr Chhatwal

Our analysis shows that these drugs would not save overall healthcare money, but would add to the budget. When something is cost effective, it does not necessarily mean it is going to save money. It essentially implies that we're willing to spend additional money to gain additional benefits...

28 Apr 2015

OHTAC recommends MRgHIFU as possible cost-effective strategy for uterine fibroid treatment

The Ontario Health Technology Advisory Committee has recommended Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MRgHIFU or MRgFUS) as a possible "cost-effective strategy" and a "safe and effective, noninvasive, uterine-preserving" option for women seeking treatment for uterine fibroids.

27 Apr 2015

Researchers move one step closer to developing effective radiotherapy for lung cancer

Radiotherapy using protons can deliver more accurate treatment to a tumour while reducing the dose to surrounding tissue. However, in mobile organs such as the lung, precise targeting of the dose is difficult. Now researchers have succeeded in making a model of breathing movement that allows for the precise measurement of narrow beams to a dummy tumour by simulating the motion and physical properties of the chest anatomy in a model, the 3rd ESTRO Forum in Barcelona, Spain, will hear today (Monday).

27 Apr 2015

Liver News and Research

Researchers reveal mechanisms involved in development of metabolic complications linked to obesity

Omega-3 fatty acids in fish oil can restore nerves damaged from diabetes

Hepatitis C common among HIV-positive patients in sub-Saharan Africa

Investigational three-drug combination clears hepatitis C in 93% of patients with liver cirrhosis

Compact Light Source generates X-ray imaging suitable for advanced computer tomography

LaVision BioTec reports on the research work of the Milan-based Iannacone Laboratory to study virus responses using intravital microscopy

Scientists identify mechanism that explains how some stem cells get new identity

Exalenz Bioscience investigates clinical utility of BreathID test to diagnose NASH

Study sheds light on long-hidden link between chronic high blood sugar and disruption of mitochondria

New study finds high levels of HCV infection among HIV-infected people across Africa

LaVision BioTec reports on the research work of the Milan-based Iannacone Laboratory to study virus responses using intravital microscopy

New study identifies enzyme that causes obesity-related hypertension

Pancreatic cancer rates higher in countries with less sunlight

Dr. Philipp Scherer to receive prestigious Banting Medal for Scientific Achievement from ADA

Fifth patient dosed in Benitec's TT-034 Phase I/IIa clinical trial for prevention of HCV infection

New study finds that sexual function in adult living donors lower at three months after transplant

Researchers pinpoint new mechanism responsible for malaria progression

Will new hepatitis C treatments strain payers’ budgets? An interview with Dr Chhatwal

OHTAC recommends MRgHIFU as possible cost-effective strategy for uterine fibroid treatment

Researchers move one step closer to developing effective radiotherapy for lung cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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