Genes News and Research

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HSV-1 infection induces strain-specific transcriptional differences in infected neurons

Why do some people with cold sores around their lips experience painful lesions, while others have no symptoms at all, yet still spread the virus? A new study conducted at Penn State finds that these differences could be due to variations in the way certain strains of herpes simplex (HSV-1) -- the virus that causes cold sores, as well as genital herpes -- activate gene expression in neurons.

29 Mar 2021

Apes mount a much stronger early immune response compared to African and Asian monkeys

A new study out of the University of Chicago and the University of Illinois Urbana-Champaign in humans, chimpanzees, rhesus macaques and baboons has found key differences in early gene expression in response to pathogen exposure, highlighting the importance of choosing the right animal model for the right questions.

29 Mar 2021

New modeling approach to better understand how tumors become aggressive

Although the development of secondary cancerous growths, called metastasis, is the primary cause of death in most cancers, the cellular changes that drive it are poorly understood.

29 Mar 2021

Rare genetic variant may explain severe COVID-19 in young healthy male patients

A recent study describes the association of rare alleles in a specific gene with severe COVID-19 in young male patients.

29 Mar 2021

GBP5 protein may play a key role in suppressing inflammation in rheumatoid arthritis

New research led by scientists at Washington State University has found that a protein known as GBP5 appears to play a key role in suppressing inflammation in rheumatoid arthritis, a potentially debilitating disease in which the immune system mistakenly attacks the body's own joint tissues.

29 Mar 2021

Researchers examine circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2

New research published in Briefings in Bioinformaticsm has identified thousands of circRNAs in Betacoronaviruses, including MERS-CoV, SARS-CoV-1, and SARS-CoV-2, from the RNA-sequencing data of viral infections. These coronaviruses have a similar genomic structure with a diverse circRNA coding ability. Researchers have also systematically characterized circRNAs in coronaviruses, with regard to their size, sequence feature, expressions, genome, location preference, and functions. This opens the door to further explore and understand the mode of action of individual circRNAs in coronaviruses.

29 Mar 2021

Researchers identify new drug candidates for treating patients with severe COVID-19

University of Maryland School of Medicine (UMSOM) researchers have identified the most toxic proteins made by SARS-COV-2--the virus that causes COVID-19 - and then used an FDA-approved cancer drug to blunt the viral protein's detrimental effects.

27 Mar 2021

Research challenges perception that dingoes are virtually extinct in the wild

Almost all wild canines in Australia are genetically more than half dingo, a new study led by UNSW Sydney shows – suggesting that lethal measures to control ‘wild dog’ populations are primarily targeting dingoes.

27 Mar 2021

Researchers identify neural circuit involved in reciprocally regulating weight gain and depression

Research has found that obesity and mental disorders such as depression and anxiety seem to often go hand in hand.

26 Mar 2021

New blood test makes it easier to follow the progression of multiple myeloma

A new method makes it much easier to follow the progression of multiple myeloma, a form of blood cancer.

26 Mar 2021

Researchers develop first human model for studying the neuronal pathology of Leigh syndrome

Leigh syndrome is the most severe mitochondrial disease in children. It causes severe muscle weakness, movement defects, and intellectual disabilities.

26 Mar 2021

Scientists reveal molecular mechanisms involved in eliminating unwanted body cells

Scientists at the Institute for Integrated Cell-Material Sciences (iCeMS) and colleagues in Japan have revealed molecular mechanisms involved in eliminating unwanted cells in the body.

26 Mar 2021

DAPK3 slows tumor growth by activating fierce-sounding STING pathway

The glow of a panther's eyes in the darkness. The zig-zagging of a shark's dorsal fin above the water. Humans are always scanning the world for threats.

26 Mar 2021

New "machine learning" method helps analyze large amounts of biological data

Studying genetic material on a cellular level, such as single-cell RNA-sequencing, can provide scientists with a detailed, high-resolution view of biological processes at work.

26 Mar 2021

Scientists describe the mechanisms that regulate embryonic stem cells

Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed by Javier Muñoz, have described the mechanisms, unknown to date, involved in maintaining embryonic stem cells in the best possible state for their use in regenerative medicine.

26 Mar 2021

Study identifies gene variants that cause metabolic deficiency in the eye

Treatments for a rare retinal disease may be on the horizon after a new study has identified gene variants that cause a metabolic deficiency in the eye.

25 Mar 2021

UB receives $1.5 million grant to develop new therapies for oral cancers

The University at Buffalo has received a $1.5 million grant from the United States Department of Defense to develop new therapies that help reduce chronic inflammation and immunosuppression in oral cancers.

25 Mar 2021

UCLA researchers receive NIH grants to identify new ways to treat pancreatic cancer

A team of researchers from the UCLA Jonsson Comprehensive Cancer Center has been awarded two research grants totaling $6 million from the National Institutes of Health to identify new ways to treat pancreatic cancer.

25 Mar 2021

Could dry swabs provide cheaper, safer and faster material for SARS-CoV-2 testing?

A new study deals with the feasibility of using dry swab samples to isolate the virus, as compared to wet swabs, to reduce costs while improving safety.

25 Mar 2021

Researchers examine SARS-CoV-2 RNA interactome

A new study focuses on the identification of RNA-binding protein by mass spectrometry (ChIRP-M/S) approach. This study develops a global map that contains the complete set of host proteins that involve the SARS-CoV-2 genome during infection. This study has successfully identified new SARS-CoV-2 host dependency factors by merging proteomics data with gene silencing experiments. Such a discovery has paved new roads to develop more antiviral therapies.

25 Mar 2021

Genes News and Research

HSV-1 infection induces strain-specific transcriptional differences in infected neurons

Apes mount a much stronger early immune response compared to African and Asian monkeys

New modeling approach to better understand how tumors become aggressive

Rare genetic variant may explain severe COVID-19 in young healthy male patients

GBP5 protein may play a key role in suppressing inflammation in rheumatoid arthritis

Researchers examine circRNAs encoded by MERS-CoV, SARS-CoV-1 and SARS-CoV-2

Researchers identify new drug candidates for treating patients with severe COVID-19

Research challenges perception that dingoes are virtually extinct in the wild

Researchers identify neural circuit involved in reciprocally regulating weight gain and depression

New blood test makes it easier to follow the progression of multiple myeloma

Researchers develop first human model for studying the neuronal pathology of Leigh syndrome

Scientists reveal molecular mechanisms involved in eliminating unwanted body cells

DAPK3 slows tumor growth by activating fierce-sounding STING pathway

New "machine learning" method helps analyze large amounts of biological data

Scientists describe the mechanisms that regulate embryonic stem cells

Study identifies gene variants that cause metabolic deficiency in the eye

UB receives $1.5 million grant to develop new therapies for oral cancers

UCLA researchers receive NIH grants to identify new ways to treat pancreatic cancer

Could dry swabs provide cheaper, safer and faster material for SARS-CoV-2 testing?

Researchers examine SARS-CoV-2 RNA interactome

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