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Tailored new compound can dramatically reduce brain damage resulting from stroke

After suffering a stroke, about three-fourths of patients exhibit some disability. The extent of a patient's symptoms depends on the degree and location of brain tissue damage following the stroke event. This week in ACS Central Science, researchers show that by using a tailored small molecule to turn off the production of a key neuromodulator in the brain, they can dramatically reduce brain damage in stroke models in rats.

10 Mar 2016

Discovery may provide potential target for new therapies to treat bipolar disorder

Bipolar disorder, which affects nearly eight million Americans, takes a toll not only on patients, but also on their families and communities.

10 Mar 2016

PAH role proposed for left heart failure biomarker

Levels of galectin-3 are elevated in patients with pulmonary arterial hypertension and correlate with disease severity, research shows.

10 Mar 2016

New imaging approach could aid earlier diagnosis of diseases

Scientists have devised a technique for visualising tissues that could aid diagnosis and treatment of diseases including cancer.

10 Mar 2016

New vaccine delays effects of nicotine within first 10 minutes after injection

Many people who smoke want to quit, but the urge to light up is often irresistible. An effective vaccine to help people kick the habit once and for all has been elusive. But now, scientists report in ACS' Journal of Medicinal Chemistry a new vaccine design that could help achieve this goal.

10 Mar 2016

Scientists discover brain mechanisms that separate food consumption from cravings

Researchers investigating eating disorders often study chemical and neurological functions in the brain to discover clues to overeating. Understanding non-homeostatic eating -- or eating that is driven more by palatability, habit and food cues -- and how it works in the brain may help neuroscientists determine how to control cravings, maintain healthier weights and promote healthier lifestyles. Scientists at the University of Missouri recently discovered the chemical circuits and mechanisms in the brain that separate food consumption from cravings. Knowing more about these mechanisms could help researchers develop drugs that reduce overeating.

9 Mar 2016

New software takes ensemble approach to determine presence of chemical structure in drug molecule

A computer program that can predict whether or not a given pharmaceutical will have worrying side effects has been developed by researchers in the USA. Md Jamiul Jahid and Jianhua Ruan of the Department of Computer Science, at the University of Texas at San Antonio, have developed the "in silico" testing system for drugs in the early stage of drug development.

9 Mar 2016

Therapy change significantly improves treatment outcomes for renal cell carcinoma patients

A research team of the Comprehensive Cancer Center of MedUni Vienna and AKH Vienna was able to demonstrate that a therapy change in the area of metastasising renal cell carcinoma significantly increases the life average expectancy and clearly improves the compatibility of the therapy.

9 Mar 2016

Nociceptin could help to reduce effects of asthma attacks

An international team of researchers from the Universities of Leicester and Naples has examined the role of a receptor in the body that could help to prevent or reduce the effects of asthma attacks.

9 Mar 2016

New possibilities in malaria drug development

Bringing three powerful chemical groups together offers new possibilities in drug development.A new chemical route for potential antimalarial compounds has been pioneered by chemists at KAUST. It offers hope for improved treatment of malaria, a disease that kills more than a million people each year

8 Mar 2016

Researchers find new link between elevation of certain amino acids and type 2 diabetes

More than 29 million Americans are currently living with diabetes. The majority have type 2 diabetes, and for them insulin resistance - their body's inability to effectively process sugar - is a part of daily life. Therefore, understanding the cause of insulin resistance is critical to tackling this chronic disease.

8 Mar 2016

Bonn scientists identify immune factor partially responsible for chronic viral infection

Many viral diseases tend to become chronic - including infections with the HI virus. In persons affected, the immune response is not sufficient to eliminate the virus permanently.

8 Mar 2016

Researchers discover how E. coli bacteria adhere to urinary tract

Almost every second woman suffers from a bladder infection at some point in her life. Also men are affected by cystitis, though less frequently. In eighty percent of the cases, it is caused by the intestinal bacterium E. coli.

8 Mar 2016

CTRC study provides new insight into how Angelina Jolie gene functions in normal breast tissue

Scientists from the Cancer Therapy & Research Center in San Antonio today (March 4) published work that provides deeper insight into how the Angelina Jolie gene, BRCA1, functions in normal breast tissue and how its loss results in breast cancer.

7 Mar 2016

American scientists produce metal-free recyclable polyester from biofeedstock-based chemical

Most plastic and polymer materials around are poorly sustainable, as they are petroleum-based, their preparation needs metal catalysis, and they persist in the environment and cannot be effectively recycled. Seeking for true sustainability, American scientists have now prepared a fully recyclable biopolyester from a biofeedstock-based chemical without any metal catalyst involved.

7 Mar 2016

Unlocking H5N1 virus replication: an interview with Martin Blackledge

We were able to show that one small domain of the polymerase, the part that is essential for entry of a piece of the polymerase into the cell nucleus, changes its conformation to allow it to interact with the transporter protein than takes it into the nucleus.

3 Mar 2016

Scientists solve first 3-D structure of DNAzyme

DNA does not always adopt the form of the double helix which is associated with the genetic code; it can also form intricate folds and act as an enzyme: a deoxyribozyme. A researcher from Spain and other scientists from the Max Planck Institute for Biophysical Chemistry (Germany) have solved the first three-dimensional structure of this biomolecule that has proved much more flexible than previously thought.

3 Mar 2016

High-fat diet may make intestinal stem cells to become cancerous

Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer. Now, a new study from Whitehead Institute and MIT's Koch Institute for Integrative Cancer Research reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous.

3 Mar 2016

TSRI researchers find way to predict therapeutic potential of stem cells against different diseases

Scientists from the Florida campus of The Scripps Research Institute have for the first time developed a way to predict how a specific type of stem cell will act against different diseases.

2 Mar 2016

Blueberry Therapeutics set to create safe, effective nanomedicines to tackle unmet healthcare needs

Blueberry Therapeutics Ltd, a leading pharmaceutical company focused on the major medical problems of inflammation and infection, are exploring the anti-microbial agenda through the development of new anti-fungal drugs and treatments to tackle this important unmet healthcare need.

2 Mar 2016

Molecule News and Research

Tailored new compound can dramatically reduce brain damage resulting from stroke

Discovery may provide potential target for new therapies to treat bipolar disorder

PAH role proposed for left heart failure biomarker

New imaging approach could aid earlier diagnosis of diseases

New vaccine delays effects of nicotine within first 10 minutes after injection

Scientists discover brain mechanisms that separate food consumption from cravings

New software takes ensemble approach to determine presence of chemical structure in drug molecule

Therapy change significantly improves treatment outcomes for renal cell carcinoma patients

Nociceptin could help to reduce effects of asthma attacks

New possibilities in malaria drug development

Researchers find new link between elevation of certain amino acids and type 2 diabetes

Bonn scientists identify immune factor partially responsible for chronic viral infection

Researchers discover how E. coli bacteria adhere to urinary tract

CTRC study provides new insight into how Angelina Jolie gene functions in normal breast tissue

American scientists produce metal-free recyclable polyester from biofeedstock-based chemical

Unlocking H5N1 virus replication: an interview with Martin Blackledge

Scientists solve first 3-D structure of DNAzyme

High-fat diet may make intestinal stem cells to become cancerous

TSRI researchers find way to predict therapeutic potential of stem cells against different diseases

Blueberry Therapeutics set to create safe, effective nanomedicines to tackle unmet healthcare needs

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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