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New technique holds promise in cancer research and science studies

A new technique reported this week in Science overcomes several limitations of typical high-throughput chemical screens conducted on cell samples. Such screens are commonly used to try to discover new cancer drugs, and in many other biomedical applications.

8 Dec 2019

Multiplexed C dots track different cancer targets to improve treatment

For more than a decade, researchers have used glowing nanoparticles called Cornell dots, or C dots, to illuminate cancer cells, target tumors and even induce cell death.

6 Dec 2019

New tool can rapidly reveal unintended changes made by CRISPR-directed gene editing

Amidst rising hopes for using CRISPR gene editing tools to repair deadly mutations linked to conditions like cystic fibrosis and sickle cell disease, a new study in the Nature journal Communications Biology describes a new innovation that could accelerate this work by rapidly revealing unintended and potentially harmful changes introduced by a gene editing process.

6 Dec 2019

Researchers identify a missed opportunity in the treatment of ER+ breast cancers

In the United States, apart from some forms of skin cancer, breast cancer is the most common cancer in women. It is also the most common cause of death from cancer among Hispanic women and the second most common among all other women, after lung cancer.

6 Dec 2019

Study sheds light on how ‘junk DNA’ affects inherited cancer risk

A person’s risk of developing cancer is affected by genetic variations in regions of DNA that don’t code for proteins, previously dismissed as ‘junk DNA’, according to new research published in the British Journal of Cancer today (Friday).

6 Dec 2019

$Novel agent opens up new treatment option for patients with refractory myeloma$

Novel agent opens up new treatment option for patients with refractory myeloma

A novel agent called Selinexor has opened up new options for the treatment of patients with refractory myeloma. This was the conclusion of a major international clinical trial in which also the Karl Landsteiner University of Health Sciences in Krems, Austria participated.

6 Dec 2019

Researchers confirm two new prognostic markers for triple negative breast cancer

Physicians who treat patients with triple negative breast cancer have two new ways to predict which patients may benefit most from the well-established post-surgery treatment known as AC chemotherapy, short for adjuvant doxorubicin and cyclophosphamide.

5 Dec 2019

New approach can improve the activity of CAR-T cells against blood and solid cancers

A new approach to programing cancer-fighting immune cells called CAR-T cells can prolong their activity and increase their effectiveness against human cancer cells grown in the laboratory and in mice, according to a study by researchers at the Stanford University School of Medicine.

5 Dec 2019

Imaging technique and machine learning may provide accurate diagnosis of colorectal cancer

Colorectal cancer is the second most common type of cancer worldwide, with about 90% of cases occurring in people 50 or older.

5 Dec 2019

NeutroCure project aims to cure inflammatory disease with neutrophils

Curing disease with neutrophils; this is the goal of the NeutroCure project. How will that work? "Neutrophils have a yin yang character," explained Andrés Hidalgo, whose team at the Centro Nacional de Investigaciones Cardiovasculares is one of six member groups participating in this project coordinated by Andriy Mokhir Friedrich from Alexander University, Germany.

5 Dec 2019

Study reports first guidelines for treating rare skin tumor

It starts as a yellow or shiny bump on the eyelids, face or body that grows and doesn't go away, unlike a pimple.

5 Dec 2019

Overabundance of novel gene in aggressive form of ovarian cancer may serve as prognostic tool

Investigators at Rutgers Cancer Institute of New Jersey have determined that an overabundance of a novel gene known as ADNP in an aggressive form of ovarian cancer may serve as a prognostic tool.

5 Dec 2019

Coriell scientist awarded grant to explore epigenetic drivers of breast cancer

Shoghag Panjarian, PhD, a research scientist at the Coriell Institute for Medical Research, has been awarded a grant from the W. W. Smith Charitable Trust to support her search for epigenetic factors that contribute to the development and growth of breast cancer.

5 Dec 2019

UPV researchers develop new methodology to monitor patients with glioblastoma

Glioblastoma is the most aggressive brain tumor in adults. Now, it can be treated with neurosurgery, radiotherapy and chemotherapy. Still, the median life expectancy of patients affected with this pathology is no longer than 15 months.

5 Dec 2019

New model can help study the mechanisms of bone metastasis, tumor immune response

The Research Team reports the establishment of B6Ca P, an allograft tumor line from a Hi-Myc transgenic mouse that had been backcrossed onto C57BL/6J background.

4 Dec 2019

Transitional T cells could help improve cancer immunotherapy

In chronic viral infections and cancer, T cell dysfunction is sure to be observed. A new study to be published in the journal Immunity shows that before these cells are completely exhausted, there is a transitory stage in which some cells are present with features that are characteristic of neither the stem-like T cells nor the mature but exhausted T cells.

4 Dec 2019

New method for discovering potential cancer-treating compounds

A new study published in the journal Cell Reports reports a novel method by which antitumor drugs that focus on reawakening exhausted immune cells called cytotoxic T cells against cancer can be quickly identified. This could help treat a large subset of cancers that thrive because of their ability to suppress antitumor activity in T cells.

4 Dec 2019

More research funding needed to improve pancreatic cancer survival rates

Pancreatic cancer is the third deadliest form of the disease after lung cancer and colorectal cancer.

4 Dec 2019

Researchers investigate NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies

The cover for issue 63 of Oncotarget features Figure 6, "Inverse relationship between ETV7 and SERPINE1 in OSCC," by Salameti, et al.

4 Dec 2019

Study highlights the need to adhere to more uniform diagnostic criteria for rare lymphoma

In what is believed to be one of the largest studies of a rare disorder known as primary cutaneous gamma delta T-cell lymphoma, Rutgers Cancer Institute of New Jersey investigators and other collaborators examined characteristics, treatment patterns and outcomes of the disease, and determined accurate diagnosis of the disease requires ongoing analysis.

4 Dec 2019

Tumor News and Research

New technique holds promise in cancer research and science studies

Multiplexed C dots track different cancer targets to improve treatment

New tool can rapidly reveal unintended changes made by CRISPR-directed gene editing

Researchers identify a missed opportunity in the treatment of ER+ breast cancers

Study sheds light on how ‘junk DNA’ affects inherited cancer risk

Novel agent opens up new treatment option for patients with refractory myeloma

Researchers confirm two new prognostic markers for triple negative breast cancer

New approach can improve the activity of CAR-T cells against blood and solid cancers

Imaging technique and machine learning may provide accurate diagnosis of colorectal cancer

NeutroCure project aims to cure inflammatory disease with neutrophils

Study reports first guidelines for treating rare skin tumor

Overabundance of novel gene in aggressive form of ovarian cancer may serve as prognostic tool

Coriell scientist awarded grant to explore epigenetic drivers of breast cancer

UPV researchers develop new methodology to monitor patients with glioblastoma

New model can help study the mechanisms of bone metastasis, tumor immune response

Transitional T cells could help improve cancer immunotherapy

New method for discovering potential cancer-treating compounds

More research funding needed to improve pancreatic cancer survival rates

Researchers investigate NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies

Study highlights the need to adhere to more uniform diagnostic criteria for rare lymphoma

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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