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Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

In the Phase I/II CodeBreaK 100 trial, the KRAS G12C inhibitor sotorasib achieved meaningful anticancer activity with an acceptable safety profile in heavily pretreated patients with KRAS G12C-mutated metastatic pancreatic cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

21 Dec 2022

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.

21 Dec 2022

Brazilian model for COVID-19 vaccination reduced severe case and mortality even from variants

A study conducted in Serrana, a small town in São Paulo state used as a model for COVID-19 vaccination in Brazil, shows that mass vaccination reduced the severe case and death rates even while the gamma and delta variants were circulating.

21 Dec 2022

Young people lack trust in the smartphone apps for receiving mental health support

Young people may not be receiving the mental health support they need because of a lack of trust in the smartphone apps that deliver such services, a study suggests.

21 Dec 2022

What are the long-term outcomes of critical COVID-19 patients?

Researchers assessed the long-term outcomes of critically ill coronavirus disease 2019 (COVID-19) patients.

21 Dec 2022

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

The Spanish Agency of Medicines and Medical Products (AEMPS) has approved the CARxALL clinical trial led by the company OneChain Immunotherapeutics (OCI).

21 Dec 2022

Onsen bathing in the evening hours linked to lower prevalence of hypertension in older Japanese adults

Nothing beats a good soak in a hot bath, and when it really hits the spot, you can almost feel your worries and ailments diffusing out into steam.

21 Dec 2022

Brief roundup of research done by experts at UCLA Health

Below is a brief roundup of news and story ideas from the experts at UCLA Health.

21 Dec 2022

Researchers devise new biomarker-based strategy to screen for myocarditis caused by cancer treatment

Researchers at Michigan Medicine have devised a new biomarker-based strategy to screen for a rare and deadly complication caused by monoclonal antibodies used to treat several cancers.

20 Dec 2022

IU researchers uncover new ways to prevent serious side effects for breast cancer patients

Researchers at Indiana University School of Medicine are learning more about ways to prevent serious side effects from chemotherapy used to treat breast cancer patients.

20 Dec 2022

Study examines the association of dementia diagnosis with risk of COVID-19 mortality

Since December 2019, more than 60 million people have been diagnosed with coronavirus disease 2019 (COVID-19) worldwide, while approximately six million individuals have died as a result of the disease.

20 Dec 2022

Can ivermectin improve the duration of sustained recovery among COVID-19 outpatients?

Researchers assessed the impact of ivermectin on the duration of sustained recovery among coronavirus disease 2019 (COVID-19) outpatients.

20 Dec 2022

Research uncovers a new way to boost the effectiveness of RNA therapies

Investigators from the Smidt Heart Institute at Cedars-Sinai have identified how biological pacemaker cells - cells that control your heartbeat - can "fight back" against therapies to biologically correct abnormal heartbeat rates.

20 Dec 2022

Rising Medicare costs linked to increased use of new prostate cancer therapies

Medicare costs for treatment of metastatic prostate cancer have risen sharply within the last 15 years – reflecting increased use of new medications under Medicare Part D, reports a study in Urology Practice, an Official Journal of the American Urological Association.

20 Dec 2022

Analysis finds more than 100 new genetic risk factors strongly linked to colorectal cancer

A comprehensive analysis of more than 100,000 colorectal cancer (CRC) cases, led by researchers at the Fred Hutchinson Cancer Center in Seattle and 200 scientific collaborators worldwide, has identified more than 100 new genetic risk factors strongly linked with the disease.

20 Dec 2022

Phenotypic plasticity may allow cancer cells to evade standard therapy

Glioblastomas (GBMs) are incurable brain tumors with a prognosis of about one-and-a half years on average. They are highly resistant to treatment and have defied all attempts at precision therapy.

20 Dec 2022

'Stem cell plasters' could revolutionize treatment for children with congenital heart disease

Researchers at the University of Bristol funded by the British Heart Foundation (BHF) have developed 'stem cell plasters' to revolutionize the way surgeons treat children living with congenital heart disease, so they don't need as many open-heart operations.

20 Dec 2022

Therapy News and Research

Sotorasib achieves meaningful anticancer activity in patients with KRAS G12C-mutated metastatic pancreatic cancer

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Brazilian model for COVID-19 vaccination reduced severe case and mortality even from variants

Young people lack trust in the smartphone apps for receiving mental health support

What are the long-term outcomes of critical COVID-19 patients?

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

Onsen bathing in the evening hours linked to lower prevalence of hypertension in older Japanese adults

Brief roundup of research done by experts at UCLA Health

Researchers devise new biomarker-based strategy to screen for myocarditis caused by cancer treatment

IU researchers uncover new ways to prevent serious side effects for breast cancer patients

Study examines the association of dementia diagnosis with risk of COVID-19 mortality

Can ivermectin improve the duration of sustained recovery among COVID-19 outpatients?

Research uncovers a new way to boost the effectiveness of RNA therapies

Rising Medicare costs linked to increased use of new prostate cancer therapies

Analysis finds more than 100 new genetic risk factors strongly linked to colorectal cancer

Phenotypic plasticity may allow cancer cells to evade standard therapy

'Stem cell plasters' could revolutionize treatment for children with congenital heart disease

Virtual reality games, eye tracking and machine learning can be used to detect ADHD

Digital interventions can help relieve depressive symptoms

Novel approach could pave the way for new treatments to prevent relapse in breast cancer patients

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