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Cleveland Clinic receives two grants to study therapeutic potential of anti-cancer drug in Alzheimer's

The National Institute of Aging, part of the National Institutes of Health, and the Alzheimer's Drug Discovery Foundation awarded five-year grants of $3.2 million and $1.4 million, respectively, to scientists from Cleveland Clinic Lou Ruvo Center for Brain Health to study the therapeutic potential of the anti-cancer drug lenalidomide in early-stage Alzheimer's disease, known as mild cognitive impairment.

27 Jan 2021

Could spironolactone treat COVID-19-related pneumonia and pulmonary fibrosis?

Researchers have described the potential of the drug spironolactone, a potassium-sparing diuretic, and anti-androgen, in preventing or alleviating the severity of COVID-19 pneumonia, and in preventing pulmonary fibrosis.

27 Jan 2021

Certain malaria parasites use a mechanism to cross the blood–brain barrier

Malaria is one of the most common causes of death in children in Africa and is triggered by a small parasite that lives in the blood. When the parasite builds up in the blood vessels of the brain, it develops into one of the most dangerous forms of the disease, cerebral malaria.

27 Jan 2021

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model

Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity.

27 Jan 2021

Two enzymes fuel transition from pre-cancer stem cells to leukemia stem cells

Since stem cells can continually self-regenerate, making more stem cells, and differentiate into many different specialized cell types, they play an important role in our development and health.

26 Jan 2021

Pain-free microneedle patch can capture biomarkers from interstitial fluid

Blood draws are no fun. They hurt. Veins can burst, or even roll - like they're trying to avoid the needle too, Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19, or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and sepsis.

26 Jan 2021

Researchers find microbiome-controlled anti-inflammatory subsets of astrocytes

Astrocytes are the most abundant type of cells within the central nervous system (CNS), but they remain poorly characterized.

26 Jan 2021

Microglial cells contribute to the negative mood experienced during neurological diseases

Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation.

26 Jan 2021

Study shows several peridomestic mammal species are potential spreaders of SARS-CoV-2

Researchers from the US and Australia show that several common peridomestic species (including deer mice, striped skunks and bushy-tailed woodrats) are amenable to infection with SARS-CoV-2.

26 Jan 2021

Hyperinflammatory conditions drive gender differences in COVID-19 severity and mortality

Recently researchers from India analyzed gender differences in COVID-19-related hyperinflammatory conditions resulting in mortality in Indian patients. The study is published on the preprint server, medRxiv*.

25 Jan 2021

Circulating antiphospholipid antibodies drive endothelial cell activation in COVID-19

With the emergence of COVID-19 (coronavirus disease 2019), researchers have been closely investigating the complex interplay between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the human immune system, and COVID-19 disease severity.

25 Jan 2021

Newly designed Biomesh minimizes postsurgical complications of hernia repair

Hernias are one of the most common soft tissue injuries. Hernias form when intra-abdominal content, such as a loop of the intestine, squeezes through weak, defective or injured areas of the abdominal wall.

25 Jan 2021

Second-generation double antibody protects from SARS-CoV-2 and its tested variants

The Institute for Research in Biomedicine (IRB; Bellinzona, Switzerland), affiliated to the Università della Svizzera italiana (USI) developed a second-generation 'double antibody' that protects from SARS-CoV-2, the virus causing COVID-19, and all its tested variants. It also prevents the virus from mutating to resist the therapy.

24 Jan 2021

Treating 'fetus as the patient' could reduce the incidence of pre-term labor and premature birth

The results of a study by researchers at the University of Texas Medical Branch may pave the way for a new medicine delivery system that could reduce the incidence of pre-term labor and premature birth by allowing physicians to treat the 'fetus as the patient'.

22 Jan 2021

NSAIDs dampen antibody and inflammatory responses to SARS-CoV-2 infection in mice

New research shows that non-steroidal anti-inflammatory drugs (NSAIDs) reduced both antibody and inflammatory responses to SARS-CoV-2 infection in mice. The study appears this week in the Journal of Virology, a publication of the American Society for Microbiology.

22 Jan 2021

Novel neutralizing antibodies targeting SARS-CoV-2 N-terminal domain discovered

A new study by US-based researchers shows the presence of protective antibodies that target the N-terminal domain (NTD) of the spike instead of the spike receptor-binding domain (RBD).

22 Jan 2021

Researchers discover direct link between placental function and future metabolic disorders

Researchers at the University of Colorado Anschutz Medical Campus have discovered a direct association between placental function in pregnant women and future metabolic disorders in children and adults, a finding that could lead to earlier intervention and diagnosis of disease.

22 Jan 2021

Inflammation News and Research

Cleveland Clinic receives two grants to study therapeutic potential of anti-cancer drug in Alzheimer's

Could spironolactone treat COVID-19-related pneumonia and pulmonary fibrosis?

Certain malaria parasites use a mechanism to cross the blood–brain barrier

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model

Two enzymes fuel transition from pre-cancer stem cells to leukemia stem cells

Pain-free microneedle patch can capture biomarkers from interstitial fluid

Researchers find microbiome-controlled anti-inflammatory subsets of astrocytes

Microglial cells contribute to the negative mood experienced during neurological diseases

Study shows several peridomestic mammal species are potential spreaders of SARS-CoV-2

Hyperinflammatory conditions drive gender differences in COVID-19 severity and mortality

Circulating antiphospholipid antibodies drive endothelial cell activation in COVID-19

Newly designed Biomesh minimizes postsurgical complications of hernia repair

Second-generation double antibody protects from SARS-CoV-2 and its tested variants

Treating 'fetus as the patient' could reduce the incidence of pre-term labor and premature birth

NSAIDs dampen antibody and inflammatory responses to SARS-CoV-2 infection in mice

Novel neutralizing antibodies targeting SARS-CoV-2 N-terminal domain discovered

Researchers discover direct link between placental function and future metabolic disorders

New model explains controversies over saturated fats and heart disease risk

SARS-CoV-2’s nonstructural proteins dysregulate immune responses, study finds

Study: Medicated drops may help close small macular holes, prevent surgery to fix vision problems

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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