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New drug-delivery strategy for central vision loss

Johns Hopkins biomedical engineers have teamed up with clinicians to create a new drug-delivery strategy for a type of central vision loss caused by blood vessel growth at the back of the eye, where such growth should not occur.

20 Aug 2013

Chinese herbal medicine JSK protects against injury caused by damage to spinal cord blood vessels

A new study published in Restorative Neurology and Neuroscience demonstrates that Chinese herbal medicine Ji-Sui-Kang (JSK), given systemically for three weeks after injury in rats, improved locomotor function, reduced tissue damage, and preserved the structure of neural cells compared to control rats.

20 Aug 2013

Advance team of molecules produced by primary tumor is responsible for lung cancer metastasis

Cancer metastasis requires tumor cells to acquire properties that allow them to escape from the primary tumor site, travel to a distant place in the body, and form secondary tumors. But first, an advance team of molecules produced by the primary tumor sets off a series of events that create a network of nurturing blood vessels for arriving primary tumor cells to set up shop.

20 Aug 2013

Researchers study connections between brain network damage and Alzheimer's disease

In patients with early Alzheimer's disease, disruptions in brain networks emerge about the same time as chemical markers of the disease appear in the spinal fluid, researchers at Washington University School of Medicine in St. Louis have shown.

20 Aug 2013

Study shows complement activation plays an important role in inherited macular degeneration

In a study published on line this week in the journal Human Molecular Genetics, Drs. Donita Garland, Rosario Fernandez-Godino, and Eric Pierce of the Ocular Genomics Institute at the Massachusetts Eye and Ear, Harvard Medical School, along with their colleagues, reported the unexpected finding that in mice genetically engineered to have an inherited form of macular degeneration, turning off the animals' complement system, a part of the immune system, prevented the disease.

20 Aug 2013

Researchers create mouse models to advance the study of unusual deadly diseases

By directly manipulating a portion of the prion protein-coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans. The highly accurate reproduction of disease pathology seen with these models should advance the study of these unusual but deadly diseases.

20 Aug 2013

Scientists study how oxidative stress in cells impacts sarcopenia in all humans as they age

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center San Antonio found.

20 Aug 2013

Copper enhances progression of Alzheimer's disease

Copper appears to be one of the main environmental factors that trigger the onset and enhance the progression of Alzheimer's disease by preventing the clearance and accelerating the accumulation of toxic proteins in the brain. That is the conclusion of a study appearing today in the journal Proceedings of the National Academy of Sciences.

20 Aug 2013

Report demonstrates clinical use of novel biomarker to assess cancer progression, inflammation

A groundbreaking peer reviewed case report by Dr. Isaac Eliaz, M.D. of Amitabha Medical Clinic, demonstrates for the first time the clinical use of novel biomarker galectin-3 to assess cancer progression and inflammation.

19 Aug 2013

Second GSK intramuscular quadrivalent influenza vaccine approved by the FDA

GlaxoSmithKline plc [LSE/NYSE: GSK] announced that the U.S. Food and Drug Administration (FDA) has approved FLULAVAL® QUADRIVALENT (Influenza Virus Vaccine) for the active immunization of persons three years of age and older to help prevent disease caused by seasonal influenza (flu) virus subtypes A and B contained in the vaccine.

19 Aug 2013

New type of cancer immunotherapy harnesses body's immune system to attack tumors

By carefully adjusting the function of crucial immune cells, scientists may have developed a completely new type of cancer immunotherapy—harnessing the body's immune system to attack tumors. To accomplish this, they had to thread a needle in immune function, shrinking tumors without triggering unwanted autoimmune responses.

19 Aug 2013

Scientists reveal how females select 'right' sperm to fertilize their eggs

University of East Anglia scientists have revealed how females select the 'right' sperm to fertilize their eggs when faced with the risk of being fertilized by wrong sperm from a different species.

19 Aug 2013

Secondary cancers in melanoma patients treated for BRAF gene mutation require new strategies

Moffitt Cancer Center researchers suggest secondary cancers seen in melanoma patients who are being treated for a BRAF gene mutation may require new strategies, such as enhanced surveillance and combining BRAF-inhibitor therapy with other inhibitors, especially as they become more widely used.

17 Aug 2013

Interactions between sympathetic neurons and pancreatic cells have implications for organ development

The human body is a complicated system of blood vessels, nerves, organs, tissue and cells each with a specific job to do. When all are working together, it's a symphony of form and function as each instrument plays its intended roles.

17 Aug 2013

Study suggests Braintone has neuroprotective effects on ischemia-induced brain damage

Recently, the importance of the neurovascular unit, which is comprised of neurons, endothelial cells and astrocytes, has received great attention in the field of stroke, because stroke affects not only neurons, but also astrocytes and microvessels.

17 Aug 2013

Arrays of nanoscale sensors detect flaws in drugs and help improve production

MIT chemical engineers have discovered that arrays of billions of nanoscale sensors have unique properties that could help pharmaceutical companies produce drugs - especially those based on antibodies - more safely and efficiently.

17 Aug 2013

UCSF study shows potential for new treatment strategy for Parkinson’s disease

UC San Francisco scientists working in the lab used a chemical found in an anti-wrinkle cream to prevent the death of nerve cells damaged by mutations that cause an inherited form of Parkinson-s disease.

17 Aug 2013

ATSP-7041 stapled peptide activates p53, suppresses tumor growth in animal models

Aileron Therapeutics, Inc., a clinical stage biopharmaceutical company that is developing first-in-class therapeutics based on its proprietary Stapled Peptide drug platform, announced today the publication of preclinical data on ATSP-7041, a potent and selective stapled peptide re-activator of the wild type p53 tumor suppressor protein.

17 Aug 2013

Michigan researchers use TACC supercomputers to understand DNA bending, repair mechanisms

The biological information that makes us unique is encoded in our DNA. DNA damage is a natural biological occurrence that happens every time cells divide and multiply. External factors such as overexposure to sunlight can also damage DNA.

17 Aug 2013

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

A phase I clinical trial showed diffuse, large B-cell lymphomas (DLBCLs) resistant to chemotherapy can be reprogrammed to respond to treatment using the drug azacitidine, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

17 Aug 2013

G Protein News and Research

New drug-delivery strategy for central vision loss

Chinese herbal medicine JSK protects against injury caused by damage to spinal cord blood vessels

Advance team of molecules produced by primary tumor is responsible for lung cancer metastasis

Researchers study connections between brain network damage and Alzheimer's disease

Study shows complement activation plays an important role in inherited macular degeneration

Researchers create mouse models to advance the study of unusual deadly diseases

Scientists study how oxidative stress in cells impacts sarcopenia in all humans as they age

Copper enhances progression of Alzheimer's disease

Report demonstrates clinical use of novel biomarker to assess cancer progression, inflammation

Second GSK intramuscular quadrivalent influenza vaccine approved by the FDA

New type of cancer immunotherapy harnesses body's immune system to attack tumors

Scientists reveal how females select 'right' sperm to fertilize their eggs

Secondary cancers in melanoma patients treated for BRAF gene mutation require new strategies

Interactions between sympathetic neurons and pancreatic cells have implications for organ development

Study suggests Braintone has neuroprotective effects on ischemia-induced brain damage

Arrays of nanoscale sensors detect flaws in drugs and help improve production

UCSF study shows potential for new treatment strategy for Parkinson’s disease

ATSP-7041 stapled peptide activates p53, suppresses tumor growth in animal models

Michigan researchers use TACC supercomputers to understand DNA bending, repair mechanisms

DLBCLs resistant to chemotherapy can be reprogrammed to respond using azacitidine

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