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Researchers use molecular dynamics simulations to identify secrets of SARS-CoV-2 virus

The virus wreaking havoc on our lives is an efficient infection machine. Comprised of only 29 proteins (compared to our 400,000), with a genome 1/200,000 the size of ours, SARS-CoV-2 is expertly evolved to trick our cells to contribute its machinery to assist in its propagation.

22 Oct 2020

Brain metabolic changes associated with loss of smell in COVID-19

A recent study detailed in a preprint paper published in medRxiv, researchers from Belgium, discuss how they investigated possible central nervous system (CNS) involvement in COVID-19 patients with a sudden loss of smell using a hybrid positron emission tomography (PET)-magnetic resonance imaging (MRI) system (PET-MR).

21 Oct 2020

Researchers explore SARS-CoV-2 at single cell resolution in human airway epithelial cells

The cellular tropism of the SARS-CoV-2 virus affects several aspects of infection, such as the spread of the virus within and between hosts, tissue pathology, immune control mechanisms, and the response to treatment with promising antiviral drugs.

21 Oct 2020

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Since the beginning of the COVID-19 pandemic, researchers have noted that women are generally less severely affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This has led to the exploration into estrogen and androgens' role in the hyperinflammatory clinical phenotypes of COVID-19. A recent study published on the preprint server bioRxiv shows that drugs targeting androgens and TMPRSS2 inhibitors may potentially combat the pandemic.

20 Oct 2020

Molecular simulations reveal detailed structure and dynamics of SARS-CoV-2 spike protein

Recently, researchers reported a study in which they analyzed the structure and dynamics of the spike protein using multiple molecular dynamic simulations. Their study is published on the preprint server bioRxiv.

19 Oct 2020

Design of an mRNA SARS-CoV-2 vaccine encapsulated in lipid nanoparticles

Now, a new study presented on the preprint server bioRxiv in October 2020 describes the efficient design of an mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on the use of the viral receptor-binding domain (RBD) mRNA encapsulated in lipid nanoparticles (LNP).

19 Oct 2020

Nanoparticles release bursts of calcium to reverse multidrug resistance in tumor cells

Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy.

16 Oct 2020

Combination of peptides and antibiotics could be key to eliminating Leishmania parasites

A combination of peptides and antibiotics could be key to eliminating the parasite causing leishmaniasis and avoiding the toxicity to people and animals caused by current drugs.

16 Oct 2020

Combination of antibiotics and peptides could eliminate parasite-causing leishmaniasis

A combination of peptides and antibiotics could be key to eliminating the parasite causing leishmaniasis and avoiding the toxicity to people and animals caused by current drugs.

16 Oct 2020

GIV protein involved in the immune system could form basis for novel therapeutics

The immune response to infections is a delicate balance. We need just enough action to clear away the offending bacteria or viruses, but not so much that our own bodies suffer collateral damage.

15 Oct 2020

Scientists find sensor protein that makes normal bladder function possible

A team co-led by scientists at Scripps Research has found that the main sensor protein enabling our sense of touch also underlies the feeling of having a full bladder and makes normal bladder function possible.

14 Oct 2020

ACE2 binding causes dissociation of trimeric SARS-CoV-2 spike, may be used to inhibit further infection

A recent study published on the preprint server bioRxiv in October 2020 shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binding to the human host receptor could cause the typical trimeric spike protein to come apart, forming a stable monomer instead with the receptor.

14 Oct 2020

Drug derived from a natural human protein could stop lethal lung damage from the flu

The raging lung inflammation that can contribute to death from the flu can be stopped in its tracks by a drug derived from a naturally occurring human protein, a new animal study suggests.

13 Oct 2020

Integrin b3 and ACE2 linked by short linear motifs enabling endocytosis and autophagy of SARS-CoV-2

A new study by Uppsala University researchers published on the preprint server bioRxiv in October 2020 shows possible links between the angiotensin-converting enzyme 2 (ACE2) host cell receptors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the entry of viral particles into the cell via endocytosis and autophagy.

12 Oct 2020

NTHU research could have significant impact on the treatment of dementia

One of the causes of neurodegenerative diseases such as Parkinson's and Alzheimer's is the calcification of the basal nucleus of the brain, which blocks the membrane protein channels on the surface of brain cells, preventing the transmission of signal molecules and nutrients to the cells.

8 Oct 2020

Study shows how amino acids are transported across liposome and cell membranes

The transport of amino acids and other molecules across the cell's membrane plays a crucial role in the metabolism of cells and, therefore, in human health.

6 Oct 2020

SARS-COV-2 traveled from China to West Africa directly or via Europe

With the onset of COVID-19, the focus of medical research has been on tracing the origin of SARS-CoV-2, which was first reported in China’s Wuhan city.

6 Oct 2020

Development of a coarse-grained model of SARS-CoV-2 virion

A team of scientists of the University of Chicago and the University of California San Diego has developed a coarse-grained (CG) model of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virion. The model can be used as a valuable resource to perform multiscale simulations of the SARS-CoV-2 virion. The study is currently available on the bioRxiv* preprint server.

5 Oct 2020

Eli Lilly's LY-CoV555 antibody shows potential as COVID-19 treatment

Researchers in the United States and Canada have discovered a monoclonal antibody that potently neutralizes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

5 Oct 2020

Macrophage subgroups may play pivotal role in COVID-19 lethality

Many researchers are attempting to identify risk factors for severe or critical COVID-19. A recent paper in the journal Medical Hypotheses in September 2020 suggests that macrophage class activation is one of the factors that determine the clinical phenotype of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

5 Oct 2020

Cell Membrane News and Research

Researchers use molecular dynamics simulations to identify secrets of SARS-CoV-2 virus

Brain metabolic changes associated with loss of smell in COVID-19

Researchers explore SARS-CoV-2 at single cell resolution in human airway epithelial cells

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Molecular simulations reveal detailed structure and dynamics of SARS-CoV-2 spike protein

Design of an mRNA SARS-CoV-2 vaccine encapsulated in lipid nanoparticles

Nanoparticles release bursts of calcium to reverse multidrug resistance in tumor cells

Combination of peptides and antibiotics could be key to eliminating Leishmania parasites

Combination of antibiotics and peptides could eliminate parasite-causing leishmaniasis

GIV protein involved in the immune system could form basis for novel therapeutics

Scientists find sensor protein that makes normal bladder function possible

ACE2 binding causes dissociation of trimeric SARS-CoV-2 spike, may be used to inhibit further infection

Drug derived from a natural human protein could stop lethal lung damage from the flu

Integrin b3 and ACE2 linked by short linear motifs enabling endocytosis and autophagy of SARS-CoV-2

NTHU research could have significant impact on the treatment of dementia

Study shows how amino acids are transported across liposome and cell membranes

SARS-COV-2 traveled from China to West Africa directly or via Europe

Development of a coarse-grained model of SARS-CoV-2 virion

Eli Lilly's LY-CoV555 antibody shows potential as COVID-19 treatment

Macrophage subgroups may play pivotal role in COVID-19 lethality

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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