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Northwestern scientists continue to advance the understanding of COVID-19

As the COVID-19 pandemic enters its third year, Northwestern Medicine scientists continue to help advance the understanding of the disease and its impact, from investigating antibody protection against COVID-19 reinfection to elevating women in academic research and highlighting racial and ethnic disparities in COVID-19 hospital mortality in Illinois.

28 Mar 2022

Neutralization of BA.1 and BA.2 Omicron variants with monoclonal antibodies

A new research paper published as an early release manuscript in the Nature Medicine journal compares the sensitivity of this strain as well as the earlier Delta and the newer BA.2 to therapeutic mAbs.

27 Mar 2022

Study finds methylene blue is a low-micromolar inhibitor of the the SARS-CoV-2 spike protein and ACE2 interaction

A new study has focussed on screening and identification of possible SMIs of this PPI for COVID-19.

25 Mar 2022

Scientists describe use of PCR in detecting SARS-CoV-2 in paraffine-embedded tissues

Scientists compared the efficacy of the quantitative polymerase chain reaction method and immunohistochemistry in detecting SARS-CoV-2 in different human tissues.

25 Mar 2022

Study indicates combining a hydrogen peroxide-based disinfectant with cellulosic copper nanoparticles lowers human coronaviruses' infectivity

A recent study indicated that combining a hydrogen peroxide-based disinfectant and cellulosic copper nanoparticles lowered human coronaviruses' infectivity.

25 Mar 2022

Adaptive immunity against SARS-CoV-2 is persistent and robust in COVID-convalescent children

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection incites adaptive cellular immune responses. In many SARS-CoV-2 studies, peripheral blood is analyzed to study the immune responses. Now, a new study under consideration at the Nature Portfolio Journal analyzes the peripheral blood, tonsils, and adenoids of children to understand local and systemic immune responses to SARS-CoV-2.

25 Mar 2022

Breast milk components show potent in vitro SARS-CoV-2 inhibition

Human breastmilk contains substances that can inhibit infection by SARS-CoV-2 and its variants, as well as prevent its replication.

24 Mar 2022

Study finds that Omicron variant preferentially uses the endosome pathway through mutation in the spike protein

A recent study assessed the role of the SARS-CoV-2 Omicron spike H655Y mutation on viral entry pathways.

24 Mar 2022

Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability

Researchers evaluated the stability and expression of mutations in the spike protein of SARS-CoV-2.

24 Mar 2022

Uptake of SARS-CoV-2 spike protein in human cerebrovascular cells

A recent study assessed the uptake of SARS-CoV-2 spike protein in human cerebrovascular cells via the lipid raft ganglioside.

24 Mar 2022

Researchers investigate Galectin-9 as a new treatment target for COVID-19

Researchers discuss alternate therapeutic targets for treating COVID-19 and the effects of Gal-9 on SARS-CoV-2 infection and the immune response.

23 Mar 2022

Recombinant SARS-CoV-2 Delta-Omicron variant identified in the United States

There is likely recombination of genome sequences between the SARS-CoV-2 Delta and Omicron variants in their spike (S) protein.

23 Mar 2022

New nanoparticle-based COVID-19 vaccine platform could target other infectious diseases

Just one dose of a new nanoparticle-based COVID-19 vaccine was enough to produce an immune response in animals on track with vaccines currently in clinical use.

23 Mar 2022

New York Blood Center and Columbia University partner to advance the use of mRNA technology in HIV vaccine study

New York Blood Center’s Project ACHIEVE and Columbia University’s Columbia Research Unit are working in partnership for the New York City effort to advance the use of messenger ribonucleic acid (mRNA) technology in an HIV preventive vaccine study – HVTN 302.

23 Mar 2022

Spike Protein News and Research

Northwestern scientists continue to advance the understanding of COVID-19

Neutralization of BA.1 and BA.2 Omicron variants with monoclonal antibodies

Study finds methylene blue is a low-micromolar inhibitor of the the SARS-CoV-2 spike protein and ACE2 interaction

Scientists describe use of PCR in detecting SARS-CoV-2 in paraffine-embedded tissues

Study indicates combining a hydrogen peroxide-based disinfectant with cellulosic copper nanoparticles lowers human coronaviruses' infectivity

Adaptive immunity against SARS-CoV-2 is persistent and robust in COVID-convalescent children

Breast milk components show potent in vitro SARS-CoV-2 inhibition

Study finds that Omicron variant preferentially uses the endosome pathway through mutation in the spike protein

Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability

Uptake of SARS-CoV-2 spike protein in human cerebrovascular cells

Researchers investigate Galectin-9 as a new treatment target for COVID-19

Recombinant SARS-CoV-2 Delta-Omicron variant identified in the United States

New nanoparticle-based COVID-19 vaccine platform could target other infectious diseases

New York Blood Center and Columbia University partner to advance the use of mRNA technology in HIV vaccine study

Importance of Numb-associated kinases in SARS-CoV-2 infection

Detection of immune and clotting dysfunction in plasma and saliva after SARS-CoV-2 infection

Study reveals differences in SARS-CoV-2 and SARS-CoV-1 spike protein conformational changes

Novel nanoparticle-based COVID vaccines induce long-term neutralizing antibody response

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Maternal and infant antibody levels and transplacental transfer following SARS-CoV-2 infection and vaccination

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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