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Radical shift required in use of heart medicine worldwide

Many people in the world who need essential heart medicine do not get it, even in rich countries, says new research published today in the medical journal The Lancet.

22 Oct 2015

Scientists find new way to inhibit growth of lung cancer cells

Scientists have identified a new way to stop the growth of lung cancer cells, by blocking their ability to use alternative sources of nutrition. The discovery was made possible by identifying the metabolic programs used by cancer cells to fuel their growth.

21 Oct 2015

Coagadex now approved by FDA for patients with hereditary Factor X deficiency

The U.S. Food and Drug Administration today approved Coagadex, Coagulation Factor X (Human), for hereditary Factor X (10) deficiency. Until today's orphan drug approval, no specific coagulation factor replacement therapy was available for patients with hereditary Factor X deficiency.

21 Oct 2015

Orange pigment may have potential as anti-cancer drug

An orange pigment found in lichens and rhubarb called parietin may have potential as an anti-cancer drug, scientists at Winship Cancer Institute of Emory University have discovered.

20 Oct 2015

Melatonin and the circadian rhythm: an interview with Professor Kennaway, University of Adelaide

The production of melatonin is controlled by a part of the brain called the suprachiasmatic nucleus (SCN) and its timing fine-tuned by our exposure to light during the morning.

20 Oct 2015

Biomedical scientists discover mechanism by which secreted proteins age

Physiological processes in the body are in large part determined by the composition of secreted proteins found in the circulatory systems, including the blood. Each of the hundreds of proteins in the blood has a specific life span that determines its unique range of abundance. In fact, measurements of their quantities and activities contribute to many clinical diagnoses.

20 Oct 2015

Breakthrough advancements on new molecular mechanism may lead to Parkinson's treatments

More than one million people in the United States are afflicted with Parkinson's disease, a progressive disorder of the brain that affects movement and coordination. The cause is typically unknown, and presently there is no cure for the disease.

19 Oct 2015

New research shows nicotine increases codeine-induced analgesia

According to new research in rat models, nicotine use over time increases the speed that codeine is converted into morphine within the brain, by increasing the amount of a specific enzyme. It appears smokers' brains are being primed for a bigger buzz from this common pain killer - which could put them at a higher risk for addiction, and possibly even overdose.

19 Oct 2015

Brown University researchers describe new method to test HIV mutations

Tests that can distinguish whether HIV-positive people are infected with a drug-resistant strain or a non-resistant strain allow patients to get the most effective treatment as quickly as possible. In the November edition of the Journal of Molecular Diagnostics, a team of Brown University researchers describes a new method that works faster and more sensitively in lab testing than the current standard technologies.

16 Oct 2015

WSU scientist wins federal grant to explore metabolism pathways, tobacco carcinogens

A Washington State University researcher has received a $2.6 million federal grant to study the body's ability to keep tobacco smoke components from causing cancer.

16 Oct 2015

Researchers create high resolution images of telomerase that plays major role in cancer, aging

An enzyme called telomerase plays a significant role in aging and most cancers, but until recently many aspects of the enzyme's structure could not be clearly seen.

16 Oct 2015

New manganese-based catalyst may accelerate drug discovery, development

Chemists have long believed that inserting nitrogen -- a beneficial ingredient for making many pharmaceuticals and other biologically active molecules -- into a carbon-hydrogen bond requires a trade-off between catalyst reactivity and selectivity.

15 Oct 2015

CWRU investigator receives $2.82 million NIH grant to make stealth bombs for brain cancer treatment

A Case Western Reserve University researcher has received a 5-year, $2.82 million National Institutes of Health grant to make, in essence, stealth bombs that slip past the brain's defenses to attack an incurable form of cancer.

15 Oct 2015

How important is a mother’s diet before pregnancy? An interview with Dr Matt Silver

In humans, much is already known about the impact of maternal undernutrition during pregnancy, and its impact on growth, development and disease throughout the life course. However, until recently little was known about the effects of the nutritional environment around the time of conception.

14 Oct 2015

Blocking the production of CHD4 protein may help increase effectiveness of AML treatments

Preclinical experiments led by a team of researchers at VCU Massey Cancer Center have shown that blocking the production of a protein known as chromodomain helicase DNA-binding protein 4 (CHD4) may help increase the effectiveness of first-line treatments for acute myeloid leukemia (AML), a particularly lethal blood cancer that is increasing in incidence among older adults.

14 Oct 2015

Tamoxifen drug clears MRSA, reduces mortality

Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences have found that the breast cancer drug tamoxifen gives white blood cells a boost, better enabling them to respond to, ensnare and kill bacteria in laboratory experiments. Tamoxifen treatment in mice also enhances clearance of the antibiotic-resistant bacterial pathogen MRSA and reduces mortality.

13 Oct 2015

Study explains why anemia is a common side effect of anti-cancer drugs

Many types of leukemia are caused by loss of enzymes such as Pten, which normally keeps cell growth in check, or conversely, the over-activation of enzymes that normally enhance cell proliferation, such as Shp2.

13 Oct 2015

Age- and gender-specific MVMM supplements can increase micronutrient status in US subpopulation

Multivitamin/Mineral Supplement Contribution to Micronutrient Intakes in the United States, 2007-2010 has been selected as the 2015 Ragus Award Winner as Best Article from the Journal of the American College of Nutrition, the official publication of the American College of Nutrition.

13 Oct 2015

Cardiac monitoring predicts survival in patients with Friedreich ataxia

Researchers confirm the need for cardiac follow-up in patients with Friedreich ataxia, with particular focus on left ventricular ejection fraction as a predictor of worse prognosis.

12 Oct 2015

Researchers reveal that supercoiled DNA's shape more dynamic than well-known double helix

Researchers have imaged in unprecedented detail the three-dimensional structure of supercoiled DNA, revealing that its shape is much more dynamic than the well-known double helix.

12 Oct 2015

Enzyme News and Research

Radical shift required in use of heart medicine worldwide

Scientists find new way to inhibit growth of lung cancer cells

Coagadex now approved by FDA for patients with hereditary Factor X deficiency

Orange pigment may have potential as anti-cancer drug

Melatonin and the circadian rhythm: an interview with Professor Kennaway, University of Adelaide

Biomedical scientists discover mechanism by which secreted proteins age

Breakthrough advancements on new molecular mechanism may lead to Parkinson's treatments

New research shows nicotine increases codeine-induced analgesia

Brown University researchers describe new method to test HIV mutations

WSU scientist wins federal grant to explore metabolism pathways, tobacco carcinogens

Researchers create high resolution images of telomerase that plays major role in cancer, aging

New manganese-based catalyst may accelerate drug discovery, development

CWRU investigator receives $2.82 million NIH grant to make stealth bombs for brain cancer treatment

How important is a mother’s diet before pregnancy? An interview with Dr Matt Silver

Blocking the production of CHD4 protein may help increase effectiveness of AML treatments

Tamoxifen drug clears MRSA, reduces mortality

Study explains why anemia is a common side effect of anti-cancer drugs

Age- and gender-specific MVMM supplements can increase micronutrient status in US subpopulation

Cardiac monitoring predicts survival in patients with Friedreich ataxia

Researchers reveal that supercoiled DNA's shape more dynamic than well-known double helix

Understanding the DNA Damage Response in Innate Immunity eBook

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