Clinical Trial News and Research

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New $7.6 million NIA grant awarded to IU for Longitudinal Early-onset AD Study

Indiana University School of Medicine has been awarded a one-year, $7.6 million grant from the National Institute on Aging to establish a network of sites to study early-onset Alzheimer's disease.

9 Oct 2017

Ebola vaccine found to be safe and effective for adults and children in Africa

Experts at St George's, University of London, have reported that an Ebola vaccine is safe for children as well as adults and produces an immune response.

6 Oct 2017

New DNA-based Zika vaccine demonstrates safety and ability to elicit immune response

A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans, according to new research from the Perelman School of Medicine at the University of Pennsylvania, conducted in partnership with The Wistar Institute, Inovio Pharmaceuticals, and GeneOne Life Science, Inc.

5 Oct 2017

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

In a recent clinical trial, a gene therapy to treat cerebral adrenoleukodystrophy (CALD) -- a neurodegenerative disease that typically claims young boys' lives within 10 years of diagnosis -- effectively stabilized the disease's progression in 88 percent of patients, researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Massachusetts General Hospital report today.

4 Oct 2017

Mount Sinai Health System announces opening of new full-service urgent care center

Mount Sinai Health System today announced the opening, at the newly renovated Mount Sinai Union Square, of a state-of-the-art, full-service urgent care center, including pediatric care, which will feature daytime, evening, and weekend hours.

4 Oct 2017

Blood test for HPV could help identify cancer patients suitable for lower treatment doses

A blood test for the human papillomavirus, or HPV, may help researchers forecast whether patients with throat cancer linked to the sexually transmitted virus will respond to treatment, according to preliminary findings from the University of North Carolina Lineberger Comprehensive Cancer Center.

4 Oct 2017

'First-in-man' clinical trial protocols often not guided by pharmacology, analysis shows

A new analysis published in the British Journal of Clinical Pharmacology indicates that 'first-in-man' clinical trial protocols in the Netherlands often lack a consistent consideration of pharmacokinetic and pharmacodynamic aspects in establishing drug doses.

4 Oct 2017

Drug treatment reduces gout flares in clinical study

As reported in the journal Arthritis & Rheumatology, the drug febuxostat reduced gout flares in a double-blind, placebo-controlled study of 314 adults with early gout.

4 Oct 2017

Virtual reality tour of operating room helps reduce preoperative anxiety in children

A virtual reality tour of the operating room prior to anesthesia helped reduce preoperative anxiety in children scheduled to undergo surgery who took part in a clinical trial published in the BJS.

4 Oct 2017

CRISPR-Gold corrects gene mutations in mice with Duchenne muscular dystrophy

Scientists at the University of California, Berkeley, have engineered a new way to deliver CRISPR-Cas9 gene-editing technology inside cells and have demonstrated in mice that the technology can repair the mutation that causes Duchenne muscular dystrophy, a severe muscle-wasting disease.

4 Oct 2017

Novel agents appear to halt growth and progression of Ewing sarcoma

When combined with an already FDA-approved chemotherapy, a novel agent developed by researchers at Georgetown Lombardi Comprehensive Cancer Center, appears to halt the ability of Ewing sarcoma to grow and progress.

4 Oct 2017

Wake Forest Baptist receives NIH grants to study risks associated with kidney transplants

The National Institutes of Health has awarded two five-year grants to Wake Forest Baptist Medical Center worth more than $5 million to prospectively study the effects of a genetic variation in organ donors that appears to contribute to survival of kidneys after transplantation.

3 Oct 2017

NIH-funded study to evaluate treatment options for newborns with opioid withdrawal syndrome

The National Institutes of Health is funding a new study to evaluate treatment options for newborns with opioid withdrawal syndrome, a condition caused by exposure to opioids during pregnancy.

3 Oct 2017

Liquid biopsy can reveal response to checkpoint inhibitor-based immunotherapies

In a first-of-its-kind study, University of California San Diego School of Medicine researchers report that a blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies.

3 Oct 2017

Study tests stepped care model of treatment for youth with anxiety

A stepped care model of treatment for youth with anxiety can be effectively delivered using at least 14% less therapist time than traditional treatment service, reports a study published in the October 2017 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.

3 Oct 2017

FDA approves Verzenio for advanced metastatic breast cancer

The U.S. Food and Drug Administration (FDA) has approved a new drug Verzenio (abemaciclib) for the treatment of advanced or metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer.

2 Oct 2017

Benefits of Biomarkers in Colorectal Cancer Treatment

Biomarkers fall into different categories: diagnostic biomarkers, are used to identify a disease; prognostic biomarkers, help clinicians to determine, for example, whether you're more likely to die or have problems with a disease; and there are some that can be used to inform treatment, to determine whether one therapy would be more successful than another.

2 Oct 2017

Clinical Trial News and Research

New $7.6 million NIA grant awarded to IU for Longitudinal Early-onset AD Study

Ebola vaccine found to be safe and effective for adults and children in Africa

New DNA-based Zika vaccine demonstrates safety and ability to elicit immune response

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

Mount Sinai Health System announces opening of new full-service urgent care center

Blood test for HPV could help identify cancer patients suitable for lower treatment doses

'First-in-man' clinical trial protocols often not guided by pharmacology, analysis shows

Drug treatment reduces gout flares in clinical study

Virtual reality tour of operating room helps reduce preoperative anxiety in children

CRISPR-Gold corrects gene mutations in mice with Duchenne muscular dystrophy

Novel agents appear to halt growth and progression of Ewing sarcoma

Wake Forest Baptist receives NIH grants to study risks associated with kidney transplants

NIH-funded study to evaluate treatment options for newborns with opioid withdrawal syndrome

Liquid biopsy can reveal response to checkpoint inhibitor-based immunotherapies

Study tests stepped care model of treatment for youth with anxiety

FDA approves Verzenio for advanced metastatic breast cancer

Benefits of Biomarkers in Colorectal Cancer Treatment

New procedure allows surgeons to reconstruct entire heart valves from patient’s own tissue

Revolutionary skin treatment offers hope to acid attack victims, burns patients

University of Hawaii researcher receives $6.3 million grant for trivalent Ebola vaccine development

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