Genes News and Research

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Somatic gene mutations in brain cells could contribute to schizophrenia pathology

Schizophrenia is a neurodevelopmental disorder that disrupts brain activity producing hallucinations, delusions, and other cognitive disturbances. Researchers have long searched for genetic influences in the disease, but genetic mutations have been identified in only a small fraction--fewer than a quarter--of sequenced patients.

9 Mar 2021

Study describes the infection of human cells by intestinal pathogen during spaceflight

Astronauts face many challenges to their health, due to the exceptional conditions of spaceflight. Among these are a variety of infectious microbes that can attack their suppressed immune systems.

9 Mar 2021

New brain sensor could transform our understanding of Alzheimer’s

Scientists at the University of Virginia School of Medicine have developed a tool to monitor communications within the brain in a way never before possible, and it has already offered an explanation for why Alzheimer's drugs have limited effectiveness and why patients get much worse after going off of them.

9 Mar 2021

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans

In a recent report made available on bioRxiv* preprint server, researchers from Poland and Finland reveal a spillover event of mink-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from farmed mink to humans after an extensive adaptation process.

9 Mar 2021

Worse problems with SARS-CoV-2 variants may be on the way

Researchers at the Department of Integrative Biomedical Sciences, University of Cape Town, South Africa, found evidence of a significant change in the selective forces acting on immunologically important SARS-CoV-2 genes, such as N and S. These likely coincided with the emergence of the 501Y lineages.

8 Mar 2021

How do viruses evolve in bats?

Bats have played a crucial epidemiological role in the evolution of many viruses and house many coronaviruses. Until 2002, coronaviruses had been known to cause mild respiratory ailments in human beings. However, this notion changed in the same year when a bat-borne virus caused the severe acute respiratory syndrome (SARS) pandemic.

8 Mar 2021

Study offers new clues to how night shift work increases cancer risk

New clues as to why night shift workers are at increased risk of developing certain types of cancer are presented in a new study conducted at Washington State University Health Sciences Spokane.

8 Mar 2021

Radiotherapy-resistant cancers could be rendered susceptible through immunotherapy treatment

Cancers that are resistant to radiotherapy could be rendered susceptible through treatment with immunotherapy, a new study suggests.

8 Mar 2021

Impairments in immune response contribute to severe COVID-19

New research by a team of scientists at University Hospital RWTH Aachen in Germany and Erasmus Medical Centre in The Netherlands characterized changes in CD8+ T cells in response to SARS-CoV-2.

8 Mar 2021

Interaction between LDL cholesterol and PRS can predict risk of heart attack

Allelica, a leading genomics software company specializing in developing polygenic risk scores (PRS) for personalised medicine, today announced publication of a study in Circulation (Vol. 143, Issue 10) showing that the effect of LDL cholesterol on a person's risk of having a heart attack depends on their genes.

8 Mar 2021

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

A new paper in the journal Life presents an early review of the viral factors involved in initiating and effecting apoptosis within infected cells.

8 Mar 2021

Diphtheria is evolving to become antibiotic-resistant and could lead to vaccine escape

Diphtheria - a relatively easily-preventable infection - is evolving to become resistant to a number of classes of antibiotics and in future could lead to vaccine escape, warn an international team of researchers from the UK and India.

8 Mar 2021

Novel bioinformatics tool could help improve COVID-19 diagnosis

An interesting new study by researchers at the University of Liverpool, University of Bristol and Public Health England in the UK describes a novel bioinformatics tool used to detect subgenomic messenger ribonucleic acid (mRNA) sequences from the virus. This may help develop new diagnostic tools and model the transmission of the virus.

8 Mar 2021

Scientists optimize wastewater disinfection process to minimize spread of antibiotic resistance

Antibiotic-resistant bacteria have become a global threat today, owing in part to the efficiency with which resistance spreads among them. Some of this spread happens in waterbodies—and our wastewater systems are no exception.

8 Mar 2021

Review helps understand the mechanisms of R-CHOP resistance in diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer of lymphocytes, and a large proportion of patients are either unresponsive or develop resistance towards R-CHOP—the standard treatment regimen.

8 Mar 2021

New method provides more control over gene drive releases

Powerful new genetic engineering methods have given scientists the potential to revolutionize several sectors of global urgency.

8 Mar 2021

Study shows how mutant huntingtin protein triggers brain cell death

In 1993, scientists discovered that a single mutated gene, HTT, caused Huntington's disease, raising high hopes for a quick cure. Yet today, there's still no approved treatment.

7 Mar 2021

Study proposes a new, noninvasive way to detect kidney transplant rejection

Patients can spend up to six years waiting for a kidney transplant. Even when they do receive a transplant, up to 20 percent of patients will experience rejection.

5 Mar 2021

Multidrug-resistant S. aureus strains may be spreading between pigs, farmworkers in North Carolina

DNA sequencing of bacteria found in pigs and humans in rural eastern North Carolina, an area with concentrated industrial-scale pig-farming, suggests that multidrug-resistant Staphylococcus aureus strains are spreading between pigs, farmworkers, their families and community residents, and represents an emerging public health threat, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

5 Mar 2021

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

A team of scientists from Italy and the USA has recently explored the maturation pattern of conventional dendritic cells (cDCs) during SARS-CoV-2 infection.

5 Mar 2021

Genes News and Research

Somatic gene mutations in brain cells could contribute to schizophrenia pathology

Study describes the infection of human cells by intestinal pathogen during spaceflight

New brain sensor could transform our understanding of Alzheimer’s

Researchers report zoonotic spillover of adapted SARS-CoV-2 from minks to humans

Worse problems with SARS-CoV-2 variants may be on the way

How do viruses evolve in bats?

Study offers new clues to how night shift work increases cancer risk

Radiotherapy-resistant cancers could be rendered susceptible through immunotherapy treatment

Impairments in immune response contribute to severe COVID-19

Interaction between LDL cholesterol and PRS can predict risk of heart attack

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

Diphtheria is evolving to become antibiotic-resistant and could lead to vaccine escape

Novel bioinformatics tool could help improve COVID-19 diagnosis

Scientists optimize wastewater disinfection process to minimize spread of antibiotic resistance

Review helps understand the mechanisms of R-CHOP resistance in diffuse large B-cell lymphoma

New method provides more control over gene drive releases

Study shows how mutant huntingtin protein triggers brain cell death

Study proposes a new, noninvasive way to detect kidney transplant rejection

Multidrug-resistant S. aureus strains may be spreading between pigs, farmworkers in North Carolina

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

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