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Researchers find mechanism that alters expression of key genes to make windows of stress-related neuroplasticity

Chronic stress can lead to changes in neural circuitry that leave the brain trapped in states of anxiety and depression. But even under repeated stress, brief opportunities for recovery can open up, according to new research at The Rockefeller University.

23 Dec 2015

New study reveals why some vestibular schwannomas cause hearing loss

A new study at Massachusetts Eye and Ear showed that in some cases of vestibular schwannoma, a sometimes-lethal tumor often associated with neurofibromatosis 2 (NF2), secretions from the tumor contain toxic molecules that damage the inner ear.

23 Dec 2015

Novoron Bioscience receives NIH grant to study novel therapeutic approach for multiple sclerosis

Novoron Bioscience, Inc., a private biotech company dedicated to developing new therapeutics for disorders of the central nervous system, today announced that the company has been awarded a National Institutes of Health grant under the Small Business Innovation Research (SBIR) Program.

22 Dec 2015

Baxalta announces initial results from ADYNOVATE Phase 3 trial for treatment of hemophilia patients

Baxalta Incorporated, a global biopharmaceutical leader dedicated to delivering transformative therapies to patients with orphan diseases and underserved conditions, today announced initial results from a Phase 3 clinical trial of ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated], an extended circulating half-life recombinant Factor VIII (rFVIII) treatment for hemophilia A based on ADVATE [Antihemophilic Factor (Recombinant)].

22 Dec 2015

Forge Therapeutics obtains exclusive license to patent rights related to novel metalloprotein inhibitors

Forge Therapeutics, Inc., a biotechnology company developing innovative medicines using a breakthrough drug discovery platform targeting metalloproteins, announced today it has obtained an exclusive license from the University of California San Diego to patent rights related to novel metalloprotein inhibitors discovered in the laboratory of Forge Therapeutics scientific co-founder Professor Seth Cohen, Ph.D.

22 Dec 2015

New study examines single 'transformer' proteins involved in cancer

A new study led by scientists at The Scripps Research Institute and St. Jude Children's Research Hospital shows how a protein involved in cancer twists and morphs into different structures.

22 Dec 2015

MD Anderson study reveals MDSCs as likely target for developing prostate cancer treatments

Immune suppressor cells called MDSCs (myeloid-derived suppressor cells) may be important in developing treatments for advanced prostate cancer, according to a study at The University of Texas MD Anderson Cancer Center.

22 Dec 2015

New study improves understanding of metal-based chemotherapy drugs

What is the mechanism of action of metal-based chemotherapy drugs (the most widely used for treating common cancers like testicular or ovarian cancer)? How can we improve their effect and reduce their toxicity? A new study combining experiments and theory has broadened our knowledge of the molecular mechanisms of these active drugs to help experimentalists devising increasingly effective drugs with fewer side effects.

21 Dec 2015

TUM scientists develop small molecule that may allow future patient-specific treatment of cancer tumours

Integrins help cells communicate with and adapt to their environment. Also cancer cells depend on their properties to survive and spread throughout the body. Now scientists at the Technical University of Munich have successfully developed a small, highly active molecule that binds to a specific integrin which operates in many types of cancer.

21 Dec 2015

MorphoSys implements Dotmatics’ Vortex to improve antibody research

Dotmatics, a leading provider of scientific informatics solutions and services, announced MorphoSys will implement Vortex to analyse and visualise their screening data enabling rapid, informed decision making. MorphoSys choose Vortex because of the intuitive nature of the product and its extensive drug discovery capabilities.

21 Dec 2015

DS Biopharma reports completion of DS102 Phase I trial for treatment of fatty liver disorders

DS Biopharma, a privately held biopharmaceutical company, today announced the successful completion of a Phase I trial with an oral formulation of the active pharmaceutical ingredient DS102 (15-HEPE) which is being explored for the treatment of fatty liver disorders, such as non-alcoholic steatohepatitis (NASH) and pulmonary disorders, such as idiopathic pulmonary fibrosis (IPF).

18 Dec 2015

UB study traces how enigmatic molecules help cancer self-destruct

You've probably never heard of "sphingolipids" before. But these curiously named organic compounds play a vital role in one of humanity's most well-known diseases: cancer.

18 Dec 2015

New test can help detect cancer and diabetes biomarkers in bloodstream

A new test for detecting biomarkers for cancer and diabetes is more than 1000x more detailed and 100% faster than existing methods, new research by the University of Warwick suggests.

18 Dec 2015

Findings show promising evidence for creating broad-spectrum antiviral

UW researchers working in collaboration with Kineta Inc. and the University of Texas at Galveston have shown that making a drug-like molecule to turn on innate immunity can induce genes to control infection in several -known viruses.

18 Dec 2015

Anti-aging Glycopeptide can improve efficacy of cell transplant treatments for diabetes patients

An antifreeze glycopeptide that mimics a naturally occurring glycoprotein found in Arctic fish is helping to significantly improve the efficacy of cell transplant treatments for diabetes patients--a procedure that transplants insulin producing islets to render them insulin independent for periods of time.

18 Dec 2015

New discovery could open door to potential treatment for West Nile virus and Dengue virus infections

A new discovery from the University of Alberta's Faculty of Medicine & Dentistry could open the door to one day treat or prevent diseases caused by West Nile virus and Dengue virus infections.

18 Dec 2015

Scientists identify overlooked consequence of spatial separation of cells into nucleus, cytoplasm

Genetically identical cells do not always behave the same way. According to the accepted theory, the reason are random molecular processes - known as random noise. For decades this view has been underpinned by numerous experiments and theoretical models.

18 Dec 2015

Cardiff scientists find way to aid recovery, reduce risk of life-threatening infections in brain damaged patients

Cardiff University scientists believe they may have found a way to aid recovery and minimise the risk of life-threatening infections in patients with traumatic brain injuries.

17 Dec 2015

Researchers identify cells that give rise to blood vessels within the kidney

In a significant step toward growing replacement kidneys, researchers at the University of Virginia School of Medicine have identified the cells that give rise to the blood vessels within the kidney. It's a discovery of critical importance, as efforts to grow kidneys have long been frustrated by the inability to create the vasculature necessary for a functional organ.

17 Dec 2015

Researchers find new way to prevent or reduce pathologies caused by malformed proteins

Improperly formed proteins can cause a host of serious illnesses, from muscular dystrophy to cystic fibrosis. A question of enormous import in research, beyond the challenge of determining how malformed proteins contribute to specific disease processes, is figuring out ways to prevent or reduce the pathologies they cause.

16 Dec 2015

Molecule News and Research

Researchers find mechanism that alters expression of key genes to make windows of stress-related neuroplasticity

New study reveals why some vestibular schwannomas cause hearing loss

Novoron Bioscience receives NIH grant to study novel therapeutic approach for multiple sclerosis

Baxalta announces initial results from ADYNOVATE Phase 3 trial for treatment of hemophilia patients

Forge Therapeutics obtains exclusive license to patent rights related to novel metalloprotein inhibitors

New study examines single 'transformer' proteins involved in cancer

MD Anderson study reveals MDSCs as likely target for developing prostate cancer treatments

New study improves understanding of metal-based chemotherapy drugs

TUM scientists develop small molecule that may allow future patient-specific treatment of cancer tumours

MorphoSys implements Dotmatics’ Vortex to improve antibody research

DS Biopharma reports completion of DS102 Phase I trial for treatment of fatty liver disorders

UB study traces how enigmatic molecules help cancer self-destruct

New test can help detect cancer and diabetes biomarkers in bloodstream

Findings show promising evidence for creating broad-spectrum antiviral

Anti-aging Glycopeptide can improve efficacy of cell transplant treatments for diabetes patients

New discovery could open door to potential treatment for West Nile virus and Dengue virus infections

Scientists identify overlooked consequence of spatial separation of cells into nucleus, cytoplasm

Cardiff scientists find way to aid recovery, reduce risk of life-threatening infections in brain damaged patients

Researchers identify cells that give rise to blood vessels within the kidney

Researchers find new way to prevent or reduce pathologies caused by malformed proteins

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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