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Research reveals MECP2 Duplication Syndrome can be reversed

The methyl CpG binding protein 2 gene (MECP2) produces a protein of the same name, the level of which is critical for normal brain function. Mutations leading to protein under-expression cause Rett Syndrome while gene duplication causing over-expression lead to MECP2 Duplication Syndrome. Both disorders are severely debilitating childhood neurological diseases.

26 Nov 2015

Bile pigment may provide natural protection from heart attacks

New hope in the fight against cardiovascular disease has arrived, following breakthrough research identifying a pigment in our bile which could protect us.

26 Nov 2015

Allergan, Rugen Therapeutics collaborate to discover and develop novel therapies for ASD and OCD

Allergan plc, a leading global pharmaceutical company, and Rugen Therapeutics, a start-up biotechnology company focused on the development of novel treatments for unmet CNS disorders and funded by the F-Prime Biomedical Research Initiative, today announced that they have entered into an exclusive collaboration to support the discovery and development of novel therapies for Autism Spectrum Disorders (ASD) and Obsessive Compulsive disorders (OCD).

25 Nov 2015

Personal glucose meters can also measure biomarkers in patient's blood, say US scientists

Not only glucose: It is possible that people use their personal glucose meters for the quantification of other biomarkers than glucose in their blood, say American scientists from the University of Illinois.

25 Nov 2015

New sensor can detect estrogen levels in liquids

Estrogen is a tiny molecule, but it can have big effects on humans and other animals. Estrogen is one of the main hormones that regulates the female reproductive system - it can be monitored to track human fertility and is sometimes administered to livestock like cows and sheep to control the reproductive cycle.

25 Nov 2015

Scientists show evidence for exchange of lactate between different brain cells

Nerve cells cover their high energy demand with glucose and lactate. Scientists of the University of Zurich now provide new support for this. They show for the first time in the intact mouse brain evidence for an exchange of lactate between different brain cells. With this study they were able to confirm a 20-year old hypothesis.

25 Nov 2015

Takeda receives FDA approval for NINLARO (ixazomib) capsules to treat patients with multiple myeloma

Takeda Pharmaceutical Company Limited today announced that the U.S. Food and Drug Administration has approved NINLARO (ixazomib) capsules, the first and only oral proteasome inhibitor, indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy. NINLARO is a once-weekly pill.

25 Nov 2015

Notre Dame researchers discover compound that speeds up diabetic wound healing

Non-healing chronic wounds are a major complication of diabetes, which result in more than 70,000 lower-limb amputations in the United States alone each year. The reasons why diabetic wounds are resistant to healing are not fully understood, and there are limited therapeutic agents that could accelerate or facilitate their repair.

23 Nov 2015

Liver's cannabinoid receptors could be targeted to combat liver cancer in some patients

A new study reveals that the liver's cannabinoid receptors could be targeted to fight liver cancer in some patients; and it offers a way to predict what treatments have the best chance of working.

23 Nov 2015

Crucial tumor-suppressing gene protects immune attack against lung cancer

A crucial tumor-thwarting gene protects an immune attack against lung cancer by blocking the key to an off switch on T cells, the customized warriors of the immune system, a team led by researchers at The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.

21 Nov 2015

Rockefeller University researchers discover molecule that helps guide axons during CNS development

During embryonic development, billions of neurons nimbly reposition themselves within the brain and spinal cord, and connect branches to form the neural circuits that ultimately control our movements, perception, and memory. Scientists have long sought to understand the driving forces in this meticulously choreographed dance, in which each cell seems to know precisely where to be to at any given time, and with what other cells it must link.

20 Nov 2015

Research findings may lead to potential therapeutic target for treating inflammatory bowel diseases

UT Southwestern Medical Center researchers have shown that a pathogen-sensing molecule plays a vital role in keeping gastrointestinal (GI) systems healthy.

20 Nov 2015

New approach to regulate people's cholesterol levels

A discovery about how the body deals with the cholesterol contained within its dying cells has suggested an exciting new approach to control people's cholesterol levels - and thus their risk of developing heart disease.

19 Nov 2015

Identifying new mechanism for aspirin in cancer prevention

Aspirin has been shown to decrease the risk of colorectal cancer and possibly other cancers. However, the risk of side effects, including in some cases severe gastrointestinal bleeding, makes it necessary to better understand the mechanisms by which aspirin acts at low doses before recommending it more generally as a preventative, says Cornelia Ulrich, PhD, Senior Director of Population Sciences at Huntsman Cancer Institute in Salt Lake City.

19 Nov 2015

NIAID launches major initiative to advance novel approaches to treat, prevent HIV infections

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, launched a major initiative to advance novel approaches to treat and prevent HIV infections based on broadly neutralizing antibodies (bNAbs) today.

19 Nov 2015

Scientists succeed in promoting regeneration of injured neurons in zebrafish by the use of light

The nervous system is built to last a lifetime, but diverse diseases or environmental insults can overpower the capacity of neurons to maintain function or to repair after trauma. A team led by Dr. Hernán López-Schier, head of the Research Unit Sensory Biology and Organogenesis at Helmholtz Zentrum München, now succeeded in promoting the repair of an injured neural circuit in zebrafish.

18 Nov 2015

Scientists develop potent compound that promotes wakefulness, remedies sleep disorder narcolepsy

Hiroshi Nagase, a Professor at the International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, collaborated with Masashi Yanagisawa (Professor / Director of WPI-IIIS) and successfully developed a potent compound that promotes wakefulness and remedies the sleep disorder narcolepsy in model animals.

18 Nov 2015

York researchers discover innovative method to make new medicines

Inspired by the classic 'ball-in-a-cup' children's toy, researchers at the University of York have discovered an innovative method to make medicinally important molecules.

18 Nov 2015

Bone protein can inhibit prostate cancer metastasis to bone

Scientists from Lawrence Livermore National Laboratory in collaboration with researchers from University of California campuses at Merced and Davis have found that a secreted protein predominantly expressed in bone inhibits prostate cancer metastasis to bone.

18 Nov 2015

Viking submits IND application to FDA to conduct VK2809 Phase 2 study in patients with LDL-C and fatty liver disease

Viking Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on the development of novel, first-in-class or best-in-class therapies for metabolic and endocrine disorders, today announced that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration to conduct a Phase 2 study of VK2809 in patients with hypercholesterolemia and fatty liver disease.

17 Nov 2015

Molecule News and Research

Research reveals MECP2 Duplication Syndrome can be reversed

Bile pigment may provide natural protection from heart attacks

Allergan, Rugen Therapeutics collaborate to discover and develop novel therapies for ASD and OCD

Personal glucose meters can also measure biomarkers in patient's blood, say US scientists

New sensor can detect estrogen levels in liquids

Scientists show evidence for exchange of lactate between different brain cells

Takeda receives FDA approval for NINLARO (ixazomib) capsules to treat patients with multiple myeloma

Notre Dame researchers discover compound that speeds up diabetic wound healing

Liver's cannabinoid receptors could be targeted to combat liver cancer in some patients

Crucial tumor-suppressing gene protects immune attack against lung cancer

Rockefeller University researchers discover molecule that helps guide axons during CNS development

Research findings may lead to potential therapeutic target for treating inflammatory bowel diseases

New approach to regulate people's cholesterol levels

Identifying new mechanism for aspirin in cancer prevention

NIAID launches major initiative to advance novel approaches to treat, prevent HIV infections

Scientists succeed in promoting regeneration of injured neurons in zebrafish by the use of light

Scientists develop potent compound that promotes wakefulness, remedies sleep disorder narcolepsy

York researchers discover innovative method to make new medicines

Bone protein can inhibit prostate cancer metastasis to bone

Viking submits IND application to FDA to conduct VK2809 Phase 2 study in patients with LDL-C and fatty liver disease

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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