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Researchers sequence salamander genome to reveal unique features of regeneration

Researchers at Karolinska Institutet in Sweden have managed to sequence the giant genome of a salamander, the Iberian ribbed newt, which is a full six times greater than the human genome.

22 Dec 2017

Genome editing approach prevents progressive hearing loss in animals

Using molecular scissors wrapped in a greasy delivery package, researchers have disrupted a gene variant that leads to deafness in mice.

20 Dec 2017

Gene editing shows promise to help people at risk of hearing loss

Gene editing could someday help people at risk of hearing loss from genetic mutations, according to research by a new Rice University faculty member.

20 Dec 2017

Stem cells remain healthy following low-dose X-ray exposure, say biophysicists

Biophysicists have shown that following low-dose exposure to X-rays (at 80 milligrays), stem cells remain healthy, proliferate, and do not accumulate DNA damage to be passed on to their progeny. The paper was published in the journal Aging.

20 Dec 2017

Epigenetics: A New Tool for Forensic Detectives

Developing analytical methods can help the triers of fact, judges and juries, better understand the events surrounding the circumstances of a crime. In forensic analysis, we are talking about determining the identity of unknown individuals through DNA and using DNA and other chemical signatures to determine and clarify the circumstances of the crime.

From Pittcon 20 Dec 2017

Scientists develop test to predict treatment outcomes in patients with childhood leukemia

UC San Francisco physician-scientists have developed a test that can predict how patients with juvenile myelomonocytic leukemia (JMML) will respond to treatment, and may also be able to identify patients who are likely to recover spontaneously with little to no treatment.

19 Dec 2017

Study identifies potential markers for early diagnosis, treatment of oral tongue cancer

Squamous cell carcinoma of the tongue, also known as oral tongue cancer, is an aggressive form of cancer that generally affects older people. Patients with the disease often find it difficult to eat, swallow food, or speak.

19 Dec 2017

Scientists identify new genes that influence how the body regulates blood pressure

Researchers at the University of Georgia have identified several new genes that influence how the body regulates blood pressure. This may help scientists develop novel blood pressure treatments or even allow them to tailor prevention strategies for individuals based on their genes.

19 Dec 2017

KU researchers win $10.8 NIH grant to study cancer, neurological disorders, lung and heart diseases

The University of Kansas' Center for Molecular Analysis of Disease Pathways, a National Institutes of Health Center of Biomedical Research Excellence, recently earned a second phase of grant funding in the amount of $10.8 million for an additional five years.

19 Dec 2017

Mutational patterns could identify breast cancer patients most likely to respond to platinum-based chemotherapy

The presence in advanced breast cancer of mutational signatures characteristic of homologous recombination deficiency (HRD) was associated with improved clinical outcomes to treatment with platinum-based chemotherapy.

19 Dec 2017

Researchers identify novel mechanism that protects from brain tumor

A group of researchers at the Spanish National Cancer Research Centre have identified a protein called RanBP6 as a new regulator of EGFR. In a paper published in Nature Communications they show how silencing of RanBP6 promoted glioma growth, by upregulating EGFR expression.

18 Dec 2017

Prostate cancer researchers find significant disparities between two liquid biopsy providers

Two Johns Hopkins prostate cancer researchers found significant disparities when they submitted identical patient samples to two different commercial liquid biopsy providers.

15 Dec 2017

Researchers uncover THOR gene involved in cancer development

It turns out Thor, the Norse god of thunder and the Marvel superhero, has special powers when it comes to cancer too.

15 Dec 2017

Researchers examine human mutations' impact on therapeutic effect of medicine

Every person has a unique DNA sequence in their genome. Now researchers from the University of Copenhagen and the MRC Laboratory of Molecular Biology in Cambridge have tried to quantify what these differences in the genome mean in the context of the genes targeted by drugs.

15 Dec 2017

Rare gene mutation gives rise to low sensitivity to pain

Researchers at University College London have identified a rare gene mutation in an Italian family who have little sensitivity to some forms of pain. Chronic pain caused by conditions such as lower back pain and osteoarthritis is one of the most prominent causes of disability worldwide, as assessed by the Global Burden of Disease reviews.

15 Dec 2017

Genome News and Research

Researchers sequence salamander genome to reveal unique features of regeneration

Genome editing approach prevents progressive hearing loss in animals

Gene editing shows promise to help people at risk of hearing loss

Stem cells remain healthy following low-dose X-ray exposure, say biophysicists

Epigenetics: A New Tool for Forensic Detectives

Scientists develop test to predict treatment outcomes in patients with childhood leukemia

Study identifies potential markers for early diagnosis, treatment of oral tongue cancer

Scientists identify new genes that influence how the body regulates blood pressure

KU researchers win $10.8 NIH grant to study cancer, neurological disorders, lung and heart diseases

Mutational patterns could identify breast cancer patients most likely to respond to platinum-based chemotherapy

Researchers identify novel mechanism that protects from brain tumor

Prostate cancer researchers find significant disparities between two liquid biopsy providers

Researchers uncover THOR gene involved in cancer development

Researchers examine human mutations' impact on therapeutic effect of medicine

Rare gene mutation gives rise to low sensitivity to pain

Researchers examine link between tumor mutational burden and response to immune checkpoint therapy

Inherited gene variation may be to blame for poor survival of patients with early-onset breast cancer

Studies reveal possibility for memory T cells to serve a dual purpose

Study finds social stigma as barrier to successful treatment of children with HIV in Ethiopia

Human ‘common cold’ virus kills healthy chimpanzees in Uganda

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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