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Researchers discover mechanism that controls activity of LRRK2 in Parkinson's disease

In one variant of Parkinson's disease, the enzyme LRRK2 plays a central role. Scientists at the University of Kassel have now discovered a mechanism that controls the activity of LRRK2.

24 Jan 2014

Early onset of dietary treatment may slow down progression of Alzheimer's, says research

New research findings indicate that an early onset of dietary treatment may slow down the progression of Alzheimer's disease. The study was conducted on mice, and the results will be published in the February issue of Journal of Nutritional Biochemistry.

24 Jan 2014

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

Investigators at Johns Hopkins report they have developed human induced-pluripotent stem cells (iPSCs) capable of repairing damaged retinal vascular tissue in mice. The stem cells, derived from human umbilical cord-blood and coaxed into an embryonic-like state, were grown without the conventional use of viruses, which can mutate genes and initiate cancers, according to the scientists.

24 Jan 2014

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes.

24 Jan 2014

OBGYN.net to present new research and topics related to cervical health

UBM Medica US announces that OBGYN.net, a leading online community for medical professionals specializing in women's health, will present new research and topics over the coming weeks related to cervical cancer and cervical health in honor of January being Cervical Health Awareness Month.

23 Jan 2014

Research reveals new information about the genetic complexity underpinning schizophrenia

The Icahn School of Medicine at Mount Sinai today announced the publication of two papers in the journal Nature that reveal new information about the genetic complexity underpinning schizophrenia. These collaborative studies represent the largest exome sequencing efforts to date to elucidate this mental illness, and together found that the disorder is likely caused by far more rare genetic mutations than previously suspected.

23 Jan 2014

Researchers discover new gene involved in severe childhood epilepsy

A European consortium of epilepsy researchers has reported the discovery of a new gene involved in severe childhood epilepsy. Using a novel combination of technologies, including trio exome sequencing of patient/parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome - a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

23 Jan 2014

Hydroxytyrosol in olive oil may help reduce risk of breast cancer

A major component of olive oil, hydroxytyrosol, is the subject of a Houston Methodist study of women who are at increased risk of developing breast cancer. The study focuses on the changes in breast density after one year of treatment and is the first of its kind in the United States.

23 Jan 2014

NCCC physicians use new gene sequencing equipment for testing abnormal DNA in cancerous tumor cells

Clinical laboratory experts and physicians at Dartmouth-Hitchcock Norris Cotton Cancer Center (NCCC) achieved 100 percent accuracy in testing for abnormal DNA in cancerous tumor cells with its new gene sequencing equipment and panels.

23 Jan 2014

Researchers find that 20% of women with ovarian cancer had inherited mutations in gene pathway

A new study conservatively estimates that one in five women with ovarian cancer has inherited genetic mutations that increase the risk of the disease, according to research at Washington University School of Medicine in St. Louis.

23 Jan 2014

Clinician scientist receives RPB Career Development Award to support eye research

The Harvard Medical School (HMS) Department of Ophthalmology has been granted a $250,000 Research to Prevent Blindness (RPB) Career Development Award to support eye research conducted by Jason I. Comander, M.D., Ph.D. The support will be provided over a four-year period.

22 Jan 2014

Advanced melanoma treatments: an interview with Dr. James Larkin, Consultant Medical Oncologist, The Royal Marsden

Advanced melanoma affects around 2,000 people per year in the UK. Advanced melanoma describes a melanoma that has spread from its site of origin to other areas of the body.

22 Jan 2014

EKF Diagnostics announces major breakthrough for PointMan DNA enrichment technology

EKF, announces a major breakthrough for its PointMan DNA enrichment technology for potential use in future cancer testing and treatment.

From EKF Diagnostics 22 Jan 2014

Researchers demonstrate existence of an epigenetic lesion in hippocampus of Alzheimer patients

Alzheimer's disease can reach epidemic range in the coming decades, by the increasing average age of society. There are two key issues for Alzheimer's disease: there is currently no effective treatment and it has been described very few associated genetic changes (mutations) which reduces the number of targets for future therapies.

22 Jan 2014

Genetic counseling delivered over telephone as effective as face-to-face counseling, says study

Genetic counseling delivered over the telephone is as effective as face-to-face counseling, finds the largest randomized study to date comparing the two methods. The multi-center study, led by researchers at Georgetown Lombardi Comprehensive Cancer Center, was reported today in the Journal of Clinical Oncology.

22 Jan 2014

Mutation in bone cells may cause acute myeloid leukemia: Study

Acute myeloid leukemia is a blood cancer, but for many patients the cancer may originate from an unusual source: a mutation in their bone cells.

21 Jan 2014

BUSM researcher receives grant for advancement in early detection, treatment of esophageal cancer

Tony Godfrey, PhD, associate chair of research in the department of surgery at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC), was recently awarded a two-year, $225,000 grant from the DeGregorio Family Foundation for Gastric and Esophageal Cancer Research & Education.

20 Jan 2014

Tumor profiling study of colorectal cancer to be presented at 2014 Gastrointestinal Cancers Symposium

Caris Life Sciences, a leading biosciences company focused on fulfilling the promise of personalized medicine, will present a large international tumor profiling study of colorectal cancer at the 2014 Gastrointestinal Cancers Symposium this week in San Francisco, Calif. With more than 7,000 patients comprehensively profiled by Caris Molecular Intelligence, this study represents the largest, multi-national analysis in a single laboratory setting of the main molecular anomalies in colorectal cancer.

18 Jan 2014

Researcher finds possible way to unravel misfolded proteins by reprogramming yeast protein

At the heart of brain diseases such as amyotrophic lateral sclerosis, Alzheimer's disease, and Parkinson's disease is protein misfolding, in which distorted proteins are unable to perform their normal functions. At present, there is no known way to reverse protein misfolding.

17 Jan 2014

Researchers managed to replicate human pancreatic beta cells in mouse model

Klaus Kaestner, PhD, professor of Genetics and postdoctoral fellow Dana Avrahami, PhD, from the Perelman School of Medicine, University of Pennsylvania, published a study this week in the Journal of Clinical Investigation, with colleague Benjamin Glaser, MD, from the Hadassah-Hebrew University Medical Center, Jerusalem, and colleagues. In this study, they were able to replicate human pancreatic beta cells - the cells in our body that produce the critical hormone insulin - in a mouse model in which donor cells were transplanted. The newly replicated cells retained features of mature beta cells and showed a physiological response to glucose.

17 Jan 2014

Mutation News and Research

Researchers discover mechanism that controls activity of LRRK2 in Parkinson's disease

Early onset of dietary treatment may slow down progression of Alzheimer's, says research

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

OBGYN.net to present new research and topics related to cervical health

Research reveals new information about the genetic complexity underpinning schizophrenia

Researchers discover new gene involved in severe childhood epilepsy

Hydroxytyrosol in olive oil may help reduce risk of breast cancer

NCCC physicians use new gene sequencing equipment for testing abnormal DNA in cancerous tumor cells

Researchers find that 20% of women with ovarian cancer had inherited mutations in gene pathway

Clinician scientist receives RPB Career Development Award to support eye research

Advanced melanoma treatments: an interview with Dr. James Larkin, Consultant Medical Oncologist, The Royal Marsden

EKF Diagnostics announces major breakthrough for PointMan DNA enrichment technology

Researchers demonstrate existence of an epigenetic lesion in hippocampus of Alzheimer patients

Genetic counseling delivered over telephone as effective as face-to-face counseling, says study

Mutation in bone cells may cause acute myeloid leukemia: Study

BUSM researcher receives grant for advancement in early detection, treatment of esophageal cancer

Tumor profiling study of colorectal cancer to be presented at 2014 Gastrointestinal Cancers Symposium

Researcher finds possible way to unravel misfolded proteins by reprogramming yeast protein

Researchers managed to replicate human pancreatic beta cells in mouse model

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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