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FDA approves first targeted cancer treatment based on basket study

The US Food and Drug Administration has announced that it has approved the drug vemurafenib for the treatment of patients with BRAF V600-mutant Erdheim-Chester disease (ECD).

7 Nov 2017

Research suggests asymptomatic infection as source of norovirus outbreaks in Indonesia

Norovirus, also referred to as the "winter vomiting bug", is the most common cause of acute gastroenteritis in humans. A Japanese research team has shown that norovirus is significantly present in the stools of healthy volunteers in Indonesia who are asymptomatically infected with the virus.

6 Nov 2017

Scientists identify eight new genes involved in epileptic encephalopathy

Approximately 30 per cent of patients with epilepsy do not respond to anti-epileptic drugs. In these cases, all neurologists can do is attempt to find the right combination of medication through trial and error.

6 Nov 2017

Environmental toxin exposure may disrupt function of circadian clock, research shows

Can environmental toxins disrupt circadian rhythms - the biological "clock" whose disturbance is linked to chronic inflammation and a host of human disorders? Research showing a link between circadian disruption and plankton that have adapted to road salt pollution puts the question squarely on the table.

3 Nov 2017

New study shows link between gut bacteria and age-related chronic inflammation

A new study shows for the first time that gut bacteria from old mice induce age-related chronic inflammation when transplanted into young mice.

3 Nov 2017

Gut bacteria can influence how cancer responds to immunotherapy

Bacteria that live in the human digestive tract can influence how cancer responds to immunotherapy, opening a new avenue for research to improve treatment, a team led by researchers at The University of Texas MD Anderson Cancer Center reports in the journal Science.

2 Nov 2017

Study solves critical piece of deafness puzzle by identifying long non-coding RNAs

A new Tel Aviv University study solves a critical piece of the puzzle of human deafness by identifying the first group of long non-coding RNAs (lncRNAs) in the auditory system.

2 Nov 2017

Discovery of genetic markers could guide individualized treatments for advanced prostate cancer

Researchers at Mayo Clinic Center for Individualized Medicine have uncovered genetic clues to why tumors resist a specific therapy used for treating advanced prostate cancer.

2 Nov 2017

Malnutrition problems may be traced to diets divergent from food in evolutionary past

Malnutrition problems can be traced to poor-quality diets lacking in diversity, a recent phenomenon in evolutionary history, according to a new paper from the Brown School at Washington University in St. Louis.

1 Nov 2017

Scientists solve decade-old mystery that could lead to development of new treatments for TB

Scientists have solved a decade-old mystery that could eventually lead to the development of earlier treatments for one of the world's deadliest diseases, which affects up to 2 billion people.

1 Nov 2017

Non-invasive diagnostic tool developed for early detection of ovarian cancer

Investigators from Brigham and Women's Hospital and Dana-Farber Cancer Institute are leveraging the power of artificial intelligence to develop a new technique to detect ovarian cancer early and accurately.

31 Oct 2017

Powerful toolkit uncovers rare tumor suppressor genes

A new statistical model has enabled researchers to pinpoint 27 novel genes thought to prevent cancer from forming, in an analysis of over 2000 tumors across 12 human cancer types. The findings could help create new cancer treatments that target these genes, and open up other avenues of cancer research.

31 Oct 2017

New gene drive approach helps pinpoint combination therapies against fungal pathogens

Candida albicans is a notorious human fungal pathogen that causes thrush and serious systemic infections. Opportunistic C. albicans fungi, which often live inconspicuously in the normal flora of human skin and gut, can switch from their harmless stealth mode to become aggressive pathogens, especially in people whose immune systems are already compromised by pre-existing diseases or harsh drug therapies.

30 Oct 2017

NASA’s “Twins Study” explores the effects space travel has on the human body

Preliminary results from NASA’s Twins Study have revealed some of the bodily changes that occurred in an astronaught, who spent almost one year in space, compared with his twin brother, who remained on earth.

30 Oct 2017

Cancer researchers make breakthrough in identifying genetic changes during immunotherapy

For some cancer patients, the road to remission and healing can have its share of speed bumps. That's particularly true of patients with non-small cell lung cancer (NSCLC) who develop a secondary, or acquired, resistance to immunotherapy, which initially was effective against their tumors.

28 Oct 2017

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Several patients with recurring glioblastoma, a deadly brain cancer, survived for more than a year in a clinical trial believed to be the first to use comprehensive DNA and RNA sequencing of a patient's tumor to inform treatment for these patients in real-time.

27 Oct 2017

‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says

Precision Medicine in oncology, where genetic testing is used to determine the best drugs to treat cancer patients, is not always so precise when applied to some of the world's more diverse populations, according to a study led by the Translational Genomics Research Institute, an affiliate of City of Hope, and the Keck School of Medicine of the University of Southern California.

27 Oct 2017

Dartmouth study uncovers three novel genetic biomarkers for lung cancer

Both environmental and genetic risk factors contribute to development of lung cancer. Tobacco smoking is the most well-known environmental risk factor associated with lung cancer. A Dartmouth research team led by Yafang Li, PhD, has conducted a study to display that gene-smoking interactions play important roles in the etiology of lung cancer.

26 Oct 2017

Wayne State researchers win NIH grant to uncover new antibiotic targets

A research team from Wayne State University has received a $1.85 million grant from the National Institute of General Medical Sciences of the National Institutes of Health for the project "Mechanisms of Non-Shine-Dalgarno Translation Initiation."

26 Oct 2017

New enzyme may one day enable genome surgery that erases harmful mutations

DNA editing just got a sharp, new pencil. Researchers have built an enzyme that can perform a previously impossible DNA swap, directly changing the DNA base pair from an A•T to a G•C.

26 Oct 2017

Genome News and Research

FDA approves first targeted cancer treatment based on basket study

Research suggests asymptomatic infection as source of norovirus outbreaks in Indonesia

Scientists identify eight new genes involved in epileptic encephalopathy

Environmental toxin exposure may disrupt function of circadian clock, research shows

New study shows link between gut bacteria and age-related chronic inflammation

Gut bacteria can influence how cancer responds to immunotherapy

Study solves critical piece of deafness puzzle by identifying long non-coding RNAs

Discovery of genetic markers could guide individualized treatments for advanced prostate cancer

Malnutrition problems may be traced to diets divergent from food in evolutionary past

Scientists solve decade-old mystery that could lead to development of new treatments for TB

Non-invasive diagnostic tool developed for early detection of ovarian cancer

Powerful toolkit uncovers rare tumor suppressor genes

New gene drive approach helps pinpoint combination therapies against fungal pathogens

NASA’s “Twins Study” explores the effects space travel has on the human body

Cancer researchers make breakthrough in identifying genetic changes during immunotherapy

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says

Dartmouth study uncovers three novel genetic biomarkers for lung cancer

Wayne State researchers win NIH grant to uncover new antibiotic targets

New enzyme may one day enable genome surgery that erases harmful mutations

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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