Protein C News and Research

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A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

A recent PLoS ONE study detected neutralizing nanobodies against SARS-CoV-2 from nanobody phage display libraries and via in vitro and ex vivo high-throughput screenings.

2 Sep 2022

Depletion of reactive astrocytes regresses glioblastoma

A groundbreaking study at Tel Aviv University effectively eradicated glioblastoma, a highly lethal type of brain cancer. The researchers achieved the outcome using a method they developed based on their discovery of two critical mechanisms in the brain that support tumor growth and survival: one protects cancer cells from the immune system, while the other supplies the energy required for rapid tumor growth. The work found that both mechanisms are controlled by brain cells called astrocytes, and in their absence, the tumor cells die and are eliminated.

2 Sep 2022

Researchers develop novel therapeutic strategy to treat Huntington's disease

Through an international joint research effort involving ProQR Therapeutics of the Netherlands, Université Grenoble Alpes of France, and KTH Royal Institute of Technology of Sweden, Professor Ji-Soon Song's research team in the Department of Biological Sciences and KAIST Institute for BioCentury of KAIST, established a noble strategy to treat Huntington's disease. The new works showed that the protein converted from disease form to its disease-free form maintains its original function, providing new roadblocks to approach Huntington's disease.

2 Sep 2022

CDC recommends Novavax's COVID-19 vaccine to be used as primary series option for adolescents

Today, CDC Director Rochelle P. Walensky, M.D., M.P.H., signed a decision memo that Novavax's COVID-19 vaccine be used as another primary series option for adolescents ages 12 through 17.

1 Sep 2022

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL).

1 Sep 2022

New substance boosts the effect of protein-based COVID-19 vaccines

Ironically, some vaccines need their own "boosters." Adding an ingredient called an adjuvant can help vaccines elicit a more robust immune response, better training the body to fight a pathogen.

1 Sep 2022

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes -genes that cause cancer when mutated - are responsible for a quarter of all human cancers, including the three tumor types with the highest mortality rates: lung adenocarcinoma, colorectal carcinoma and pancreatic ductal adenocarcinoma.

1 Sep 2022

Researchers identify how some cancer cells cheat treatment-induced cell death

Scientists at St. Jude Children's Research Hospital have identified how some cancer cells cheat treatment-induced cell death.

1 Sep 2022

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

A team that includes Rutgers scientists has designed a synthetic protein that quickly detects molecules of a deadly nerve agent that has been classified by the United Nations as a weapon of mass destruction and could be used in a chemical warfare attack.

1 Sep 2022

Inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth

Researchers at Sanford Burnham Prebys, led by Ze'ev Ronai, Ph.D., have shown for the first time that inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth.

1 Sep 2022

Simple blood test may identify patients at high risk of neurotoxic complications after CAR-T cell therapy

Cell-based immunotherapy called CAR-T cell therapy has revolutionized the treatment of several cancers.

1 Sep 2022

Researchers demonstrate improved culture of primate induced pluripotent stem cells

The following study transplanted iPSCs derived from two NHP species, chimpanzee and pigtailed macaque, into blastocysts from another NHP species – the rhesus macaque.

1 Sep 2022

Intranasally delivered neutralizing antibody protects against SARS-CoV-2 Omicron and Delta variants

The current study focused on the ability of this nmAb to neutralize Delta, Omicron, and other VOCs, as well as its efficacy when given by the intranasal route in an animal model.

1 Sep 2022

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

In a new study, researchers assessed the effects of N501Y mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein on binding to angiotensin-converting enzyme-2 (ACE-2).

1 Sep 2022

Less is more: early short-course rapamycin effective in sustained anti-aging effects

A new study shows that a brief treatment period could have the same anti-aging efficacy and duration of effect but without the potentially serious adverse effects of chronic administration.

1 Sep 2022

How does origin impact antiviral immune response?

A new study observed differential antiviral responses in Indian and European individuals.

1 Sep 2022

dsDNA Quantification for NGS Quality Control

Andrew Jones discusses the importance of quality control in NGS and the effect that a poorly followed protocol can have on experimental results.

From DeNovix Inc. 1 Sep 2022

Improving 1 µL UV-Vis Spectrophotometry Sample Results

Prior to microvolume spectrophotometry, UV-Vis quantification of biomolecules was performed using quartz cuvettes with a 10mm pathlength.

From DeNovix Inc. 1 Sep 2022

Detection of a novel bird flu virus with pandemic potential

A recent virological study published in the Emerging Infectious Diseases journal identified the novel influenza A virus (H3N8) in live poultry in Hong Kong, genetically similar to the zoonotic H3N8 viruses reported in mainland China with its origin akin to H5N1, H5N6, H10N8, and H7N9 viruses.

31 Aug 2022

What lessons can we learn from the COVID-19 pandemic for HIV?

A new study discussed how experiences from the coronavirus disease 2019 (COVID-19) pandemic could be leveraged for human immunodeficiency virus (HIV).

31 Aug 2022

Protein C News and Research

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

Depletion of reactive astrocytes regresses glioblastoma

Researchers develop novel therapeutic strategy to treat Huntington's disease

CDC recommends Novavax's COVID-19 vaccine to be used as primary series option for adolescents

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

New substance boosts the effect of protein-based COVID-19 vaccines

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

Researchers identify how some cancer cells cheat treatment-induced cell death

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

Inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth

Simple blood test may identify patients at high risk of neurotoxic complications after CAR-T cell therapy

Researchers demonstrate improved culture of primate induced pluripotent stem cells

Intranasally delivered neutralizing antibody protects against SARS-CoV-2 Omicron and Delta variants

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

Less is more: early short-course rapamycin effective in sustained anti-aging effects

How does origin impact antiviral immune response?

dsDNA Quantification for NGS Quality Control

Improving 1 µL UV-Vis Spectrophotometry Sample Results

Detection of a novel bird flu virus with pandemic potential

What lessons can we learn from the COVID-19 pandemic for HIV?

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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