Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Research reveals potential target for therapies to prevent severe allergic reactions

Allergies can be life-threatening when they cause anaphylaxis, an extreme reaction with constriction of the airways and a sudden drop in blood pressure.

2 Aug 2019

Researchers explore how HIV spreads in 3D tissue-like environments

The spread of pathogens like the human immunodeficiency virus (HIV) is often studied in a test tube, i.e. in two-dimensional cell cultures, even though it hardly reflects the much more complex conditions in the human body.

25 Jul 2019

New vaccine shows promise against toughest HIV strains

A new study reports successful immunization against a so-far invincible “death star” strain of an HIV-related laboratory virus (SIVmac239) and another tough strain. The new approach also achieves long-term protection with a single dose, showing that gene therapy could allow broad and durable protection, based on a modified form of the CD4 protein that allows HIV entry into human cells.

24 Jul 2019

HIV DNA persists in spinal fluid despite treatment, linked to cognitive impairment

Many people living with the human immunodeficiency virus (HIV) and using antiretroviral therapy (ART) may still have cells sheltering the virus lurking in the cerebrospinal fluid, a new study has found.

16 Jul 2019

People living with HIV have increased risk for heart diseases and face health challenges

Effective antiretroviral therapy has changed the human immunodeficiency virus (HIV) from a progressive, fatal disease to a chronic, manageable condition that is associated with higher rates of heart attacks, strokes, heart failure, sudden cardiac deaths, and other diseases compared to people without HIV, according to a new scientific statement from the American Heart Association published in the Association journal Circulation.

3 Jun 2019

University of Freiburg to receive 25.8 million euros for collaborative research centers

The Deutsche Forschungsgemeinschaft has approved grant applications for two collaborative research centers at the University of Freiburg: one for continued grant funding, and one for initial grant funding.

24 May 2019

University of Miami establishes AIDS Research Center to curb HIV epidemic

The United Nation's goal of ending AIDS around the world by 2030 is undeniably ambitious, but within tantalizing reach.

23 May 2019

Monkey-infecting virus shows promise as potential component of future HIV vaccine

A protein from Simian Immunodeficiency Virus, which can infect monkeys and apes, has shown promise as a potential component of a vaccine against Human Immunodeficiency Virus, in a new study from scientists at Scripps Research in La Jolla, California.

22 May 2019

CU Anschutz researchers identify new immunodeficiency disease

A new immunodeficiency disease caused by a novel genetic mutation has been identified by researchers at the University of Colorado Anschutz Medical Campus providing unique insights into cell biology.

6 May 2019

Breakthrough antibody treatment suppresses HIV without antivirals

A new research paper describes how an antibody that prevents HIV binding to human immune cells was shown to be able to suppress levels of HIV for up to four months.

18 Apr 2019

New gene therapy cures babies with fatal 'Bubble Boy' disease

A new gene therapy created by US researchers appears to have cured eight infant boys born with a rare genetic disorder referred to as “Bubble Boy” disease.

18 Apr 2019

UTMB receives grant to combat highly-lethal hemorrhagic fever viruses

The University of Texas Medical Branch at Galveston, Profectus Biosciences, Vanderbilt University Medical Center, Mapp Biopharmaceutical and Genevant Sciences Corp. have been awarded up to $35 million to advance the development of rapid-acting vaccines and broad-spectrum treatments of the highly-lethal hemorrhagic fever viruses Ebola and Marburg.

9 Apr 2019

FDA approves two-drug complete regimen for previously untreated HIV-infected adults

The U.S. Food and Drug Administration today approved Dovato (dolutegravir and lamivudine), as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults with no antiretroviral treatment history and with no known or suspected substitutions associated with resistance to the individual components of Dovato.

9 Apr 2019

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

Human immunodeficiency virus, or HIV, attacks the immune system, making affected individuals more susceptible to infections. When patients with HIV are treated with antiretroviral therapy, their immune system can recover, but some of them produce self-destructive proteins, or autoantibodies.

2 Apr 2019

Researchers find cause, treatment for CVID lung disease using precision medicine

Researchers have identified that dysfunction of a specific immune cell, called B cells, underlies lung disease that affects patients with the rare immunological disorder known as common variable immunodeficiency.

8 Mar 2019

Up-to-date guidance for clinicians to treat HIV-related cardiovascular disease

Since the advent of effective antiretroviral therapy, human immunodeficiency virus infection has become more like a chronic illness.

5 Mar 2019

Custom-made proteins could result in antibodies that fight HIV

Researchers have developed a new method for the creation of custom-made proteins that can bypass the protective coating of the HIV virus.

28 Feb 2019

Study reveals how helper T cells support memory cells to function optimally

The immune system's killer T cells are crucial in fighting viral infections. A fraction of them, called 'memory cells', live on once infection is controlled in order to fight re-infection by the same virus. They are of great interest as the basis of T cell-based vaccination and immunotherapies.

20 Feb 2019

Anti-cancer immunotherapy could be used to fight HIV

Researchers at the University of Montreal Hospital Research Centre have shown that immunotherapy treatments against cancer could reduce the amount of virus that persists in people on triple therapy.

19 Feb 2019

Antibody-based treatment could improve cure rate for blood and immune disorders

An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at the Stanford University School of Medicine.

12 Feb 2019