Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

FDA approves two-drug complete regimen for previously untreated HIV-infected adults

The U.S. Food and Drug Administration today approved Dovato (dolutegravir and lamivudine), as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults with no antiretroviral treatment history and with no known or suspected substitutions associated with resistance to the individual components of Dovato.

9 Apr 2019

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

Human immunodeficiency virus, or HIV, attacks the immune system, making affected individuals more susceptible to infections. When patients with HIV are treated with antiretroviral therapy, their immune system can recover, but some of them produce self-destructive proteins, or autoantibodies.

2 Apr 2019

Researchers find cause, treatment for CVID lung disease using precision medicine

Researchers have identified that dysfunction of a specific immune cell, called B cells, underlies lung disease that affects patients with the rare immunological disorder known as common variable immunodeficiency.

8 Mar 2019

Up-to-date guidance for clinicians to treat HIV-related cardiovascular disease

Since the advent of effective antiretroviral therapy, human immunodeficiency virus infection has become more like a chronic illness.

5 Mar 2019

Custom-made proteins could result in antibodies that fight HIV

Researchers have developed a new method for the creation of custom-made proteins that can bypass the protective coating of the HIV virus.

28 Feb 2019

Study reveals how helper T cells support memory cells to function optimally

The immune system's killer T cells are crucial in fighting viral infections. A fraction of them, called 'memory cells', live on once infection is controlled in order to fight re-infection by the same virus. They are of great interest as the basis of T cell-based vaccination and immunotherapies.

20 Feb 2019

Anti-cancer immunotherapy could be used to fight HIV

Researchers at the University of Montreal Hospital Research Centre have shown that immunotherapy treatments against cancer could reduce the amount of virus that persists in people on triple therapy.

19 Feb 2019

Antibody-based treatment could improve cure rate for blood and immune disorders

An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at the Stanford University School of Medicine.

12 Feb 2019

When genomic sequencing fails to diagnose a rare disease

Routine sequencing has given unprecedented insight into the genetics of rare diseases, but genomics fails to diagnose up to half of patients who are tested. That's the problem German scientists tackled in a recent study in the journal Molecular & Cellular Proteomics.

11 Feb 2019

New measurable indicator could prove instrumental in fight against HIV

George Mason University's Yuntao Wu is the lead scientist on a research team that has identified a measurable indicator that could prove instrumental in the fight against HIV.

11 Feb 2019

FDA grants clearance to Hologic’s assay for detection of common sexually transmitted infections

Hologic, Inc. announced today that the U.S. Food and Drug Administration (FDA) has granted clearance for its Aptima Mycoplasma genitalium assay, the first and only FDA-cleared test to detect this under-recognized but increasingly common sexually transmitted infection (STI).

23 Jan 2019

Scientists solve mystery of Yemen cholera epidemic

The most likely source of the cholera epidemic in Yemen has been discovered by scientists. Through the use of genomic sequencing, scientists at the Wellcome Sanger Institute and Institut Pasteur estimate the strain of cholera causing the current outbreak in Yemen - the worst cholera outbreak in recorded history - came from Eastern Africa and entered Yemen with the migration of people in and out of the region.

2 Jan 2019

Study: Reactivation of HIV-infected cells depends on its size and cell cycle

Thanks to the development of antiretroviral drugs, human immunodeficiency virus is considered a manageable chronic disease today.

27 Dec 2018

Experimental HIV vaccine strategy works in non-human primates, research shows

For more than 20 years, scientists at Scripps Research have chipped away at the challenges of designing an HIV vaccine. Now new research, published in Immunity, shows that their experimental vaccine strategy works in non-human primates.

14 Dec 2018

MUHC's 'Dr. House' discovers new genetic disease and the gene responsible for it

A team from the Research Institute of the McGill University Health Centre led by Dr. Donald Vinh, the RI's so-called "Dr. House" because of his research into rare diseases, has discovered a new human disease and the gene responsible for it, paving the way for the proper diagnosis of patients globally and the development of new therapies.

7 Dec 2018

Young black gay men are more likely to have HIV infection than their white peers

Young black men who have sex with men are 16 times more likely to have an HIV infection than their white peers despite more frequent testing for HIV and being less likely to have unsafe sex, reports a new Northwestern Medicine study.

5 Dec 2018

Researchers aim to develop a functional cure for HIV using therapeutic vaccines

EU-funded researchers are leading efforts to develop a functional cure for HIV using innovative therapeutic vaccines to halt the progression of the devastating virus, increase the availability and affordability of treatment, and improve patients' quality of life.

30 Nov 2018

ECDC and WHO release latest data on HIV epidemic in the European Region

The European Centre for Disease Prevention and Control and the WHO Regional Office for Europe release the latest data on the HIV epidemic in the European Region, marking the 30th anniversary of World AIDS Day.

29 Nov 2018

Study reveals direct link between stigma and cognitive performance in people with HIV

A new study has drawn a direct link between the amount of stigma men with HIV report experiencing and their scores on cognitive tests, measuring abilities such as memory and attention.

27 Nov 2018

Scientists develop new surgical process for studying the thymus

Elisa Oltra, head of the Genetic Exppression and Immunity group of the Faculty of Medicine at the Catholic University of Valencia, in collaboration with Alejandro Caicedo, professor of the Department of Medicine of the University of Miami, have developed a surgical process which makes it possible to place functional fragments of the thymus in the anterior chamber of the eyes of mice.

26 Nov 2018