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Scientists put ehrlichiosis under the genomic spotlight

Ehrlichiosis is no star of science. This emerging disease has an awkward name, vague flu-like symptoms, and a nasty habit of being caused by bacteria that live inside ticks and flatworms.

17 Feb 2006

Genome data may contain small but significant errors

Since the genome sequence of the bacterial pathogen Haemophilus influenzae was published in 1995, the genetic code of many other large, complex, medically, and commercially significant organisms including humans has also been elucidated

17 Feb 2006

Scientists investigate sugar coating that surrounds bacteria

Scientists at The University of Texas at Austin have developed a quick and simple way to investigate the sugar coating that surrounds bacteria and plays a role in infection and immunity.

16 Feb 2006

X chromosome dosage compensation proven in germ cells

X chromosome dosage compensation does occur in germ cells. A study published today in the open access journal Journal of Biology reveals that expression of the genes on the X chromosome is doubled in Drosophila germ cells to compensate for the missing second X chromosome.

16 Feb 2006

miRNA emerge as a class of gene regulators

Scientists have discovered that a wide variety of different cancers actually share something in common - a molecular "signature" made up of tiny bits of genetic material called microRNA (miRNA) that target key cancer genes and promote malignant growth.

7 Feb 2006

Key genes identified that enable tuberculosis infection to spread

Scientists in India, led by a Howard Hughes Medical Institute (HHMI) international research scholar, have identified five key genes that enable Mycobacterium tuberculosis to acquire the iron it needs to sustain growth and promote infection

5 Feb 2006

Researchers show how estrogen turns genes on and off during cancer progression

Ohio - A new study suggests that the hormone estrogen works in partnership with other proteins to activate or suppress gene activity in breast cancer cells.

2 Feb 2006

New method to find new metabolites

Ever since penicillin, a byproduct of a fungal mold, was discovered in 1929, scientists have scrutinized fungi for other breakthrough drugs. As reported Jan. 20 in the Journal of Chemistry and Biology, a team led by a University of Wisconsin-Madison researcher has developed a new method that may speed the ongoing quest for medically useful compounds in fungi.

23 Jan 2006

Scientists discover method to multiply an adult stem cell 30-fold

Adult stem cells may be free of the ethical concerns that hamper embryonic stem cell research, but they still pose formidable scientific challenges.

23 Jan 2006

Cloned stem cells are perfectly normal

Scientists generally agree that all cloned animals are biologically flawed. But they don't agree about what that means for stem cells derived from cloned embryos, the basis for therapeutic cloning.

18 Jan 2006

Genetic cause of autism

The researchers at the U School of Medicine made the finding by tracing variations in the DNA of an extended Utah family that has a high occurrence of the disorder and whose members are descended from one couple.

18 Jan 2006

Physiogenomic resources for rat models of heart, lung and blood disorders

Every year, heart disease claims an estimated 7 million lives, according to the World Health Organization. Scientists have struggled to pinpoint the precise genes behind this complex disease. Now, however, they have a new research ally: the designer rat.

16 Jan 2006

Gene discovery may reinvigorate the body's immune system after fighting viral infections

Like boxers wearied by a 15-round bout, the immune system's CD8 T cells eventually become "exhausted" in their battle against persistent viral infection, and less effective in fighting the disease.

29 Dec 2005

New drug shows promise in fighting Tuberculosis (TB)

Scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have determined how a promising drug candidate attacks the bacterium that causes tuberculosis (TB). Published online this week in Proceedings of the National Academy of Sciences, the finding may help scientists optimize the drug candidate, PA-824, which targets Mycobacterium tuberculosis (M. tb).

28 Dec 2005