Nucleotide News and Research

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The emergence and evolution of SARS-CoV-2 and its VOCs

A review article discusses the evolution of SARS-CoV-2 and the emergence of variants of concern.

5 Dec 2021

CRISPR-based DETECTR® assay for faster SARS-CoV-2 surveillance

Researchers from the USA discuss the development and validation of CRISPR-Cas12-based COVID-19 variant DETECTR® assay for the detection of SARS-CoV-2.

3 Dec 2021

Host and in vitro genomic variability of SARS-CoV-2 and its variants

Researchers from the University of Sydney investigate the genomic variability of SARS-CoV-2 within the host and in vitro.

30 Nov 2021

From tiny particles to big success: Knauer awarded the innovation prize for Berlin Brandenburg

The producer of high-tech laboratory systems, KNAUER Wissenschaftliche Geräte GmbH was awarded the prestigious Innovation Prize for the Berlin Brandenburg region for their new system for the production of lipid nanoparticles (LNPs).

From KNAUER Wissenschaftliche Geräte GmbH 30 Nov 2021

Error rate of bacterial DNA polymerase is consistently higher under microgravity, study shows

On 22 May 2019, scientists from Queen's University boarded a modified Falcon 20 aircraft at Ottawa airport. Scheduled was a 'vomit comet' flight, where the plane repeatedly climbs to 8km in a steep parabola, alternating with a descent in freefall.

29 Nov 2021

Genetic variations affect and rewire phosphorylation signaling networks in SARS-CoV-2 infection

Researchers study human single nucleotide variants (SNVs) using machine learning to identify amino acid changes that alter kinase-bound sequence motifs.

29 Nov 2021

Complex RNA structures could have untapped therapeutic potential in the fight against COVID-19

To the untrained eye, the loops, kinks and folds in the single strand of RNA that makes up the coronavirus genome look like a jumble of spaghetti or tangled yarn. But to researchers like Amanda Hargrove, a chemistry professor at Duke University, the complex shapes that RNA takes on as it folds upon itself could have untapped therapeutic potential in the fight against COVID-19.

26 Nov 2021

Breakthrough infections from SARS-CoV-2 Delta variant among vaccinated healthcare workers

A new study published on the medRxiv* preprint server employed in-silico techniques, combining genomic and epidemiological data, to determine possible Delta-variant transmission events between vaccinated healthcare workers (HCWs) in Indian hospitals.

25 Nov 2021

Study uncovers important genetic predispositions for acute myeloid leukemia

The National Center for Tumor Diseases Dresden is a joint institution of the German Cancer Research Center, the University Hospital Carl Gustav Carus Dresden, Carl Gustav Carus Faculty of Medicine at TU Dresden and the Helmholtz-Zentrum Dresden-Rossendorf.

24 Nov 2021

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

A new study evaluates the efficacy of SNX-5422 as a post-exposure prophylactic treatment.

23 Nov 2021

An increase in the half-life of remdesivir for COVID-19 treatment

In this study, researchers analyzed several drug candidates to investigate their efficacy against a broad spectrum of coronaviruses in cell culture studies.

23 Nov 2021

Cryo-EM reveals how the DNA replication machinery assembles at DNA damage sites

Cryogenic electron microscopy (cryo-EM) has enabled researchers to study how the DNA replication machinery assembles at sites where DNA is damaged.

22 Nov 2021

New study highlights the important role of rare genomic differences in OCD risk

Both rare and commonly observed differences in the DNA letters strung along a person's chromosomes can explain about a third of the risk for being diagnosed with obsessive-compulsive disorder (OCD), according to a new study led by scientists at the Icahn School of Medicine at Mount Sinai.

18 Nov 2021

Novel strategy to produce SARS-CoV-2 nucleocapsid protein for serological testing

New research discusses an alternative method of purifying the SARS-CoV-2 N protein using only metal exchange chromatography and denaturing conditions.

18 Nov 2021

Toll-like receptor 2 - novel target for improved COVID-19 vaccines

In a new study, researchers from French and American institutes analyzed at a molecular level the interaction between SARS-CoV-2 E protein and human TLR2.

17 Nov 2021

Game animals as potential drivers of disease emergence

A study characterized the total virome of game animals from five mammalian orders using the total RNA sequencing technique.

17 Nov 2021

Ensemble cryo-electron microscopy uncovers conformational states of the nsp13 helicase of SARS-CoV-2

With this background, the goal of a new study published on the bioRxiv* preprint server was to use cryo-electron microscopy to investigate the nsp13 helicase conformational states in order to gain insights of how nsp13 functions during viral transcription/replication.

16 Nov 2021

Rare disease diagnosis by 100,000 genomes pilot

A team of researchers conducted a pilot study that enrolled families and undertook detailed clinical phenotyping of the proband to evaluate the effect of the whole genome sequencing approach on a genetic diagnosis of rare conditions by the NHS in the UK.

12 Nov 2021

Identification of a candidate effector gene at COVID-19 risk locus

A new study focuses on developing a comprehensive platform to decode the effects of sequence variation identified by GWAS.

8 Nov 2021

Study looks at how lupus genetics intersects with COVID-19

The study “Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19” was recently published on the preprint medRxiv* server.