RNA Sequencing News and Research

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New research lays foundation to create standards for RNA sequencing

The idea of testing blood or urine to find markers that help diagnose or treat disease holds great promise. But as technology has improved to allow researchers to examine tiny fragments of RNA, one major problem has led to limited success.

17 Jul 2018

Researchers reveal massive genome havoc in breast cancer

In cancer cells, genetic errors wreak havoc. Misspelled genes, as well as structural variations -- larger-scale rearrangements of DNA that can encompass large chunks of chromosomes -- disturb carefully balanced mechanisms that have evolved to regulate cell growth.

13 Jul 2018

Single-cell RNA sequencing reveals how complex brain circuit works

The complexity of the human brain presents scientists with immense challenges as they try to find new treatments for a host of diseases and conditions. But the advent of a new technology known as single-cell RNA sequencing is opening a window into how the brain works.

6 Jul 2018

Researchers report unusually high levels of herpesvirus in the brains of people with Alzheimer's disease

Two strains of human herpesvirus-;human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) -;are found in the brains of people with Alzheimer's disease at levels up to twice as high as in those without Alzheimer's, researchers from the Icahn School of Medicine at Mount Sinai report.

21 Jun 2018

Scientists identify new subtype of prostate cancer

Researchers led by the University of Michigan Rogel Cancer Center have identified a new subtype of prostate cancer that occurs in about 7 percent of patients with advanced disease.

14 Jun 2018

Researchers develop novel tool to analyze millions of single cells simultaneously

New research led by Holger Heyn at the Centro Nacional de Análisis Genómico of the Centre for Genomic Regulation, presents a sophisticated computational framework to analyze single-cell gene expression levels, scalable to process millions of individual cells.

From 10x Genomics, Inc. 6 Jun 2018

Researchers use 'multiomics' approach to study newborn mouse heart

During the first days of life, the heart of a newborn mouse adapts to entirely new physiological conditions, larger volume loads and an increased energy demand. As a result, fundamental changes occur in the heart. Studies have shown that the heart of neonate mouse retains its ability to effectively repair tissue damage.

4 Jun 2018

Scientists identify three new distinct breast epithelial cell populations

Researchers from the University of California, Irvine School of Medicine, in collaboration with scientists at UCSF and Northwestern University, have profiled human breast epithelial cells, identifying three new distinct epithelial cell populations.

1 Jun 2018

Scientists report involvement of estrogen hormone receptor in autoimmune diseases

Women are more prone to the development of autoimmune diseases. The female hormone estrogen is likely to affect the immune system.

1 Jun 2018

Researchers work together to solve mystery of motor neuron death in ALS patients

As the old adage goes, 'two heads are better than one'. With the development of new technologies and increasingly specialist expertise, ground-breaking science needs to be a team effort.

25 May 2018

Researchers reveal potent new mechanism of action for treatment of IBD

Professor Akiyoshi Fukamizu's research group of Life Science Center for Survival Dynamics, University of Tsukuba, Eisai Co., Ltd. and its gastrointestinal business subsidiary EA Pharma Co., Ltd. have revealed a mechanism in which an analogue (ER-464195-01) of Eisai's in-house discovered E6007 inhibits integrin activation by dissociating interaction between calreticulin (CRT) and integrin α 4 (ITGA4), suppressing adhesion and infiltration of leukocytes overall.

25 May 2018

Malaria-causing parasite seeks refuge inside the liver to replicate and survive

When the malaria-causing Plasmodium parasite first slips into the human bloodstream, injected by the bite of an infected mosquito, it does not immediately target red blood cells.

23 May 2018

Schizophrenics' blood samples feature genetic material from more types of microorganisms

The blood of schizophrenia patients features genetic material from more types of microorganisms than that of people without the debilitating mental illness, research at Oregon State University has found.

22 May 2018

Researchers push science one step closer to growing body parts in a lab

Researchers have learned that precursor cells for skeletal muscles actually also give rise to neurons, blood vessels, blood cells and immune cells, pushing science one step closer to generating body parts in a laboratory.

17 May 2018

Researchers discover genetic signal common to cerebral palsy and autism

University of Adelaide researchers have uncovered a genetic signal common to both cerebral palsy and autism.

10 May 2018

Study reveals the genetics underlying cerebral palsy and autism

Researchers from the Robinson Research Institute at the University of Adelaide have uncovered a genetic signal that is common to both cerebral palsy and autism.

10 May 2018

Scientists successfully graft neural precursor cells into spinal cords of syngeneic pigs with no immunosuppression

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material, necessitating the use of complex drugs and techniques to suppress the host's immune response.

10 May 2018

Cancer scientists confirm oligometastasis hypothesis

In 1995, two University of Chicago-based cancer specialists suggested there was an intermediate state -; somewhere between curable localized cancers and lethal widespread disease -; for patients with metastatic cancer.

7 May 2018

Cell lineage is not pre-determined, finds new study

Scientists have mapped the developmental trajectories of more than 40,000 individual cells and found that cell fates are determined much later than previously thought.

27 Apr 2018

Study may explain how chemoresistance evolves over time in some triple-negative breast cancers

Triple-negative breast cancer is an aggressive form of the disease accounting for 12 to 18 percent of breast cancers. It is a scary diagnosis, and even though chemotherapy can be effective as standard-of-care, many patients become resistant to treatment.

20 Apr 2018