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Targeting MAPK4 enzyme may be a potential new strategy to combat prostate cancer

The battle against late-stage prostate cancer might have found a potential new strategy to combat this deadly disease.

20 Feb 2021

Uninherited genetic mutations can cause spina bifida

Genetic mutations which occur naturally during the earliest stages of an embryo's development can cause the severe birth defect spina bifida, finds a new experimental study in mice led by UCL scientists.

19 Feb 2021

Study reveals genetic signature of colibactin implicated in the development colorectal cancers

Escherichia coli bacteria are constitutive members of the human gut microbiota. However, some strains produce a genotoxin called colibactin, which is implicated in the development of colorectal cancer.

18 Feb 2021

A new method for controlling leukemic stem cells

Leukemia is caused by leukemic stem cells which are resistant to most known therapies. Relapses are also due to this resistance. Leukemic stem cells arise from normal blood-forming (hematopoietic) stem cells.

17 Feb 2021

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

New zebrafish model could help advance glioblastoma multiforme research

Scientists at the Fralin Biomedical Research Institute at VTC have identified a new zebrafish model that could help advance glioblastoma multiforme research. Glioblastoma is an aggressive form of primary brain tumor - fewer than one in 20 patients survive five years after diagnosis.

13 Feb 2021

A new method to determine how carcinogenic bacteria reach their targets

The gram-negative bacteria Helicobacter pylori (H. pylori) colonize the stomachs of the majority of the world's population.

11 Feb 2021

Compound isolated from Ophiura sarsii can be used as an affordable drug for photodynamic therapy

An unusual biologically active porphyrin compound was isolated from seabed dweller Ophiura sarsii. The substance might be used as an affordable light-sensitive drug for innovative photodynamic therapy and for targeted treatment of triple-negative breast cancer and some other cancers.

8 Feb 2021

Study implicates disruption in prenatal neurogenesis in the development of ASDs

A new study of autism risk genes by UC San Francisco and UC Berkeley scientists implicates disruption in prenatal neurogenesis - a process in which specialized "progenitor" cells give rise to new brain cells - in the development of autism spectrum disorders (ASDs).

8 Feb 2021

Study reveals a novel role for Smurf2 protein in regulating bone formation

Bone morphogenetic protein (BMP) has a strong osteogenic (bone forming) ability. BMP has already been clinically applied to spinal fusion and non-union fractures.

8 Feb 2021

Researchers elucidate mechanism by which blood and lymph vessels remain separated

Researchers from Kumamoto University (Japan) have clarified the mechanism by which blood and lymph vessels remain segregated from one another after development.

6 Feb 2021

Moffitt researchers reveal why some ovarian cancer patients evolve better than others

The prognosis of ovarian cancer is poor, with an estimated five-year survival of only 40% for advanced disease, the stage at which most ovarian carcinomas are diagnosed.

3 Feb 2021

Zinc supplementation bolsters repurposed antivirals against SARS-CoV-2

A new preprint reports the efficacy of two repurposed drugs that could be useful against SARS-CoV-2 when supplemented with zinc.

2 Feb 2021

Can metformin reduce mortality in diabetic individuals with severe COVID-19?

A new study by researchers in China and the U.S. describes a round-up of the effects of commonly used hypoglycemic drugs on the outcomes of COVID-19 in diabetic patients.

1 Feb 2021

Synergistic effect between NF-κB inhibitors and zinc in vitro reducing ACE2 expression

Researchers at National Taiwan University Hospital in Taipei have conducted a study demonstrating the potential effectiveness of a novel drug combination at reducing morbidity and mortality in coronavirus disease 2019 (COVID-19).

31 Jan 2021

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Using the developing eye of the fruit fly as a test platform, researchers found that RPS-12 protein overproduction appears to trigger triple-negative breast cancer and possibly some other malignancies.

29 Jan 2021

Study uncovers a novel promising target for diabetes treatment

Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The latest study from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes Research is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery.

27 Jan 2021

Study shows how gut bacteria can dull the efficacy of radiotherapy

A study led by Ludwig Chicago Co-director Ralph Weichselbaum and Yang-Xin Fu of the University of Texas Southwestern Medical Center has shown how bacteria in the gut can dull the efficacy of radiotherapy, a treatment received by about half of all cancer patients.

26 Jan 2021

Anti-emetic drug offers a promising approach to treat chronic myeloid leukemia

Chronic myeloid leukemia (CML) results from a degeneration of the hematopoietic stem cells (leukemia stem cells), thereby leading to the uncontrolled formation of specific white blood cells, the so-called granulocytes.

26 Jan 2021

Pancreatic β cell-derived exosomal miR-29s manipulate glucose homeostasis

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs).

22 Jan 2021

Signaling Pathway News and Research

Targeting MAPK4 enzyme may be a potential new strategy to combat prostate cancer

Uninherited genetic mutations can cause spina bifida

Study reveals genetic signature of colibactin implicated in the development colorectal cancers

A new method for controlling leukemic stem cells

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

New zebrafish model could help advance glioblastoma multiforme research

A new method to determine how carcinogenic bacteria reach their targets

Compound isolated from Ophiura sarsii can be used as an affordable drug for photodynamic therapy

Study implicates disruption in prenatal neurogenesis in the development of ASDs

Study reveals a novel role for Smurf2 protein in regulating bone formation

Researchers elucidate mechanism by which blood and lymph vessels remain separated

Moffitt researchers reveal why some ovarian cancer patients evolve better than others

Zinc supplementation bolsters repurposed antivirals against SARS-CoV-2

Can metformin reduce mortality in diabetic individuals with severe COVID-19?

Synergistic effect between NF-κB inhibitors and zinc in vitro reducing ACE2 expression

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Study uncovers a novel promising target for diabetes treatment

Study shows how gut bacteria can dull the efficacy of radiotherapy

Anti-emetic drug offers a promising approach to treat chronic myeloid leukemia

Pancreatic β cell-derived exosomal miR-29s manipulate glucose homeostasis

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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