B Cell News and Research

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Breakthrough discovery could lead to new treatments for brain metastases

When cancer that starts in the body metastasizes to the brain, it is almost always lethal, in part because so few treatment options exist. Now a new study by Wistar scientists published in Nature Communications shows that a type of brain cell called astrocytes plays an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells.

24 Jun 2023

FUJIFILM Irvine Scientific offers expanded capabilities of Presagen’s Life Whisperer Platform to aid with clinical decision-making in IVF

Genetics AI-based software module added to provide objective scoring of embryo genetic integrity and likelihood of clinical pregnancy.

From FUJIFILM Irvine Scientific 24 Jun 2023

Single-cell profiling reveals immune cell marker and regulator of anti-tumor immunity

B cells are thought to play a critical role in innate and adaptive immunity, but their exact role in anti-tumor immunity remains unknown.

23 Jun 2023

Eliminating cancer cell repopulation may be the key to curing cancer

A new research perspective was published in Oncoscience (Volume 10) on June 1, 2023, entitled, "Cancer cell repopulation after therapy: which is the mechanism?"

23 Jun 2023

3D models of ovarian cancer reveal how cell’s location can affect tumor biology

Using 3-D models of ovarian cancer tumors, scientists found differences in gene activity based on where a cell is in a tumor, demonstrating how a cell's location and environment in a cancerous tumor can strongly influence which genes are active and the cell's role in the cancer's biology.

23 Jun 2023

BU study reveals crucial signaling pathway that drives head and neck cancers

Despite advances in defining the genomic characteristics of head and neck cancers, these malignancies continue to rank among the deadliest cancers with few targeted therapies available.

23 Jun 2023

Scientists discover new way to defeat invisible cancer cells

Modern immunotherapies boost the body's own defenses against cancer. They activate killer T cells of the immune system that can specifically recognize and destroy cancer cells.

23 Jun 2023

BU researcher receives $2.8M grant to study serotonin's role in chronic stress and depression

Michael Wallace, PhD, assistant professor of anatomy & neurobiology at Boston University Chobanian & Avedisian School of Medicine, was awarded a $2.8 million from the National Institutes of Health, National Institute of Mental Health.

23 Jun 2023

New project aims to improve the efficacy and safety of CAR T therapies for solid tumors

Partners in the international consortium CAR T-REX announce the awarding of a highly competitive EIC Pathfinder Open grant, following the positive evaluation of their project entitled 'CAR T Cells Rewired to Prevent EXhaustion in the Tumour Microenvironment'.

23 Jun 2023

The use of bacterial colonists as therapy carriers is gaining interest for treating cancer

Study describes the use of engineered commensal bacteria to increase antitumor immunity.

23 Jun 2023

Prior exposure to air pollutants and black carbon load predicts outcomes in hospitalized COVID-19 patients

Researchers investigated whether black carbon particles in the blood increased COVID-19 severity.

23 Jun 2023

Cell and gene therapy CDMO Andelyn Biosciences celebrates over 20 years of leadership and innovation with opening of new 180,000 square foot manufacturing headquarters

Andelyn Biosciences, a pioneer in the development and manufacturing of cell and gene therapies, today formally inaugurates its new manufacturing headquarters, the Andelyn Corporate Center (ACC), located in the Innovation District in Columbus, Ohio.

From Andelyn Biosciences 23 Jun 2023

Key viral protein produced by influenza A can shred a host cell's genetic materials, finds study

Influenza A is one of two influenza viruses that fuel costly annual flu seasons and is a near constant threat to humans and many other animals. It's also responsible for occasional pandemics that, like the one in 1918, leave millions dead and wreak havoc on health systems and wider society.

23 Jun 2023

Analyzing the conformational dynamics of a human tRNA using high hydrostatic pressure

Just as space holds infinite mysteries, when we zoom in at the level of biomolecules (one trillion times smaller than a meter), there is still so much to learn.

23 Jun 2023

Deciphering a biochemical mechanism explains the center of protein factories

Based on genetic blueprints, individual amino acids are assembled into long amino acid chains, the proteins, in the protein factories of our cells, the ribosomes. Each newly formed protein starts with the amino acid methionine.

23 Jun 2023

Pangolin study uncovers novel strains of coronaviruses and raises concerns about origin

Researchers identify novel HKU4-related coronavirus in a pangolin single-cell sequencing dataset.

22 Jun 2023

Study reveals contrasting effects of sucralose on insulin and glucose control

Sucralose, a commonly used artificial sweetener, has contrasting effects on insulin secretion and glucose homeostasis. While bolus administration of sucralose enhances insulin secretion and decreases glucose levels, long-term consumption exacerbates insulin resistance and glucose intolerance, particularly in combination with a high-fat diet. The study highlights the involvement of the T1R3-ERK1/2 pathway in sucralose-induced insulin resistance in the liver.

22 Jun 2023

New standard more effective at preventing graft-versus-host disease

Clinicians have a new standard for graft-versus-host disease (GVHD) prevention after allogeneic hematopoietic stem cell transplantation, according to results from a phase III study published June 22 in the New England Journal of Medicine.

22 Jun 2023

Study finds new way to predict therapy response in metastatic renal cell carcinoma

Dr. Niklas Klümper, resident at the Department of Urology and Pediatric Urology of the University Hospital Bonn (UKB) and working group leader at the Institute for Experimental Oncology (IEO), and Dr. Jonas Saal, resident at the Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology of the UKB, demonstrated a significant improvement in predicting the response to therapy in metastatic renal cell carcinoma by incorporating the level of inflammation, which was assessed using two straightforward blood parameters, alongside the conventional imaging-based approach.

22 Jun 2023

World's largest gathering of NF community convenes in Arizona to advance research and care

From June 21 through June 27, the largest gathering of NF researchers, clinicians, and patients in the world will take place at the Fairmont Scottsdale Princess in Scottsdale, Arizona.

22 Jun 2023

B Cell News and Research

Breakthrough discovery could lead to new treatments for brain metastases

FUJIFILM Irvine Scientific offers expanded capabilities of Presagen’s Life Whisperer Platform to aid with clinical decision-making in IVF

Single-cell profiling reveals immune cell marker and regulator of anti-tumor immunity

Eliminating cancer cell repopulation may be the key to curing cancer

3D models of ovarian cancer reveal how cell’s location can affect tumor biology

BU study reveals crucial signaling pathway that drives head and neck cancers

Scientists discover new way to defeat invisible cancer cells

BU researcher receives $2.8M grant to study serotonin's role in chronic stress and depression

New project aims to improve the efficacy and safety of CAR T therapies for solid tumors

The use of bacterial colonists as therapy carriers is gaining interest for treating cancer

Prior exposure to air pollutants and black carbon load predicts outcomes in hospitalized COVID-19 patients

Cell and gene therapy CDMO Andelyn Biosciences celebrates over 20 years of leadership and innovation with opening of new 180,000 square foot manufacturing headquarters

Key viral protein produced by influenza A can shred a host cell's genetic materials, finds study

Analyzing the conformational dynamics of a human tRNA using high hydrostatic pressure

Deciphering a biochemical mechanism explains the center of protein factories

Pangolin study uncovers novel strains of coronaviruses and raises concerns about origin

Study reveals contrasting effects of sucralose on insulin and glucose control

New standard more effective at preventing graft-versus-host disease

Study finds new way to predict therapy response in metastatic renal cell carcinoma

World's largest gathering of NF community convenes in Arizona to advance research and care

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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