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Researchers identify new way to help AML patients avoid a relapse

A protein domain once considered of little importance may be key to helping patients who are fighting acute myeloid leukemia (AML) avoid a relapse.

8 Sep 2015

University of Bonn researchers find how cells in the body can detect genetic material of retroviruses

Researchers at the University of Bonn have discovered how cells in the body can detect the genetic material of so-called retroviruses. The pathogen of the immunodeficiency disease AIDS, the HI-1 virus, also belongs to this group. At the same time, the HI virus appears to circumvent this important defense mechanism.

8 Sep 2015

Researchers reveal molecular mechanism that controls remyelination

Researchers in Japan have revealed the molecular mechanism involved in the process of repair to damage of the myelin sheath. In vertebrates, axons extending from nerve cells are covered by insulating sheets called the myelin sheath, made with the cell membranes of oligodendrocytes, enabling fast electrical signaling through saltatory conduction.

4 Sep 2015

Aspirin may help boost effectiveness of cancer treatment

Giving cancer patients aspirin at the same time as immunotherapy could dramatically boost the effectiveness of the treatment, according to new research published in the journal Cell today (Thursday).

3 Sep 2015

Mitochondrial Pyruvate Carrier could potentially be a new drug target to treat diabetes

High blood sugar is a defining characteristic of Type 2 diabetes and the cause of many of the condition's complications, including kidney failure, heart disease, and blindness. Most diabetes medications aim to maintain normal blood sugar (glucose) levels and prevent high blood sugar by controlling insulin.

3 Sep 2015

HUYA Bioscience International expands HBI-8000 clinical trials for breast cancer

HUYA Bioscience International (HUYA) today announced expanding clinical trials with its lead cancer drug, HBI-8000, starting with a Phase 1 combination trial in support of a breast cancer program to be conducted in the United States.

3 Sep 2015

Volatile anesthetics may combat viral and bacterial infections in the lung

In use for more than a century, inhaled anesthetics like nitrous oxide and halothane have made modern surgery possible. Now, in experiments in mice, researchers at Johns Hopkins and elsewhere have added to evidence that certain so-called "volatile" anesthetics -- commonly used during surgeries -- may also possess powerful effects on the immune system that can combat viral and bacterial infections in the lung, including influenza and pneumonia.

2 Sep 2015

Amgen, Novartis collaborate for Alzheimer's disease and migraine programs

Amgen today announced a neuroscience collaboration with Novartis in the areas of Alzheimer's disease and migraine. The collaboration accelerates Amgen's potential entry into Alzheimer's disease by teaming up with Novartis on a differentiated and genetically validated Alzheimer's disease program directed at genetically predisposed individuals at risk of developing Alzheimer's disease.

2 Sep 2015

Sanofi terminates option and license agreement for Ardelyx's portfolio of NaP2b inhibitors

Ardelyx, Inc., a clinical-stage biopharmaceutical company focused on gastrointestinal and cardio-renal diseases, today announced that Sanofi notified Ardelyx of its termination of the option and license agreement for Ardelyx's portfolio of NaP2b inhibitors effective September 30, 2015.

2 Sep 2015

SLU scientist receives grant to solve blood-clotting mysteries

Last summer, SLU scientists made a breakthrough discovery about the way in which blood clots. Through X-ray crystallography, they solved the molecular structure of prothrombin, an important blood-clotting protein, revealing an unexpected, flexible role for a "linker" region that may be the key to developing better life-saving drugs.

1 Sep 2015

Treating cancer cells with quizartinib inhibits key metabolic pathway, activates macroautophagy

A study published in The Journal of Cell Biology describes a way to force cancer cells to destroy a key metabolic enzyme they need to survive.

1 Sep 2015

Scientists closer to understanding how neurons are wired to form circuits in the eye

When we move our head, the whole visual world moves across our eyes. Yet we can still make out a bee buzzing by or a hawk flying overhead, thanks to unique cells in the eye called object motion sensors.

1 Sep 2015

Scientists elucidate chemical process behind eosinophilic esophagitis

Scientists from the D'Or Institute of Research and Education, the Federal University of Rio de Janeiro and the Yale University School of Medicine have elucidated the chemical process behind a mysterious gastrointestinal disease that is becoming more frequent every day: the eosinophilic esophagitis (EoE), also known as the "asthma of the esophagus".

1 Sep 2015

UCSF-led team develops new technique to create tiny models of human tissues

A UCSF-led team has developed a technique to build tiny models of human tissues, called organoids, more precisely than ever before using a process that turns human cells into a biological equivalent of LEGO bricks. These mini-tissues in a dish can be used to study how particular structural features of tissue affect normal growth or go awry in cancer. They could be used for therapeutic drug screening and to help teach researchers how to grow whole human organs.

1 Sep 2015

Resverlogix presents new data on RVX-208 orally active BET inhibitor at ESC Congress 2015

Resverlogix Corp. is pleased to announce that Dr. Norman Wong, chief scientific officer of Resverlogix Corp. presented new data at the European Society of Cardiology (ESC) Congress 2015 in a poster presentation titled: "RVX-208, an orally active BET inhibitor, lowers CVD risk by activities beyond raising ApoA-I/HDL."

31 Aug 2015

Biocompatible scaffold enables beating heart cells to snap together like Velcro

Engineers at the University of Toronto just made assembling functional heart tissue as easy as fastening your shoes. The team has created a biocompatible scaffold that allows sheets of beating heart cells to snap together just like Velcro™.

29 Aug 2015

Scientists reveal role of dynamin and show how specific mutations impair function of dynamin

Cells continually form membrane vesicles that are released into the cell. If this vital process is disturbed, nerve cells, for example, cannot communicate with each other. The protein molecule dynamin is essential for the regulated formation and release of many vesicles.

28 Aug 2015

Can-Fite BioPharma announces Q2 financial results for 2015, updates drug development programs

Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs being developed to treat inflammatory diseases, cancer and sexual dysfunction, today reported financial results for the six months ended June 30, 2015 and updates on its drug development programs.

28 Aug 2015

Findings reveal a new way to prevent meningitis

The fungus Cryptococcus causes meningitis, a brain disease that kills about 1 million people each year — mainly those with impaired immune systems due to AIDS, cancer treatment or an organ transplant.

28 Aug 2015

AMCP issues statement in response to FDA’s draft guidance requiring nonproprietary names for biological products

The Academy of Managed Care Pharmacy (AMCP) is disappointed in the Food and Drug Administration's (FDA's) draft guidance and proposed rule that calls for biologics, including reference products and biosimilars, to bear a nonproprietary name with an FDA-designated suffix.

28 Aug 2015

Molecule News and Research

Researchers identify new way to help AML patients avoid a relapse

University of Bonn researchers find how cells in the body can detect genetic material of retroviruses

Researchers reveal molecular mechanism that controls remyelination

Aspirin may help boost effectiveness of cancer treatment

Mitochondrial Pyruvate Carrier could potentially be a new drug target to treat diabetes

HUYA Bioscience International expands HBI-8000 clinical trials for breast cancer

Volatile anesthetics may combat viral and bacterial infections in the lung

Amgen, Novartis collaborate for Alzheimer's disease and migraine programs

Sanofi terminates option and license agreement for Ardelyx's portfolio of NaP2b inhibitors

SLU scientist receives grant to solve blood-clotting mysteries

Treating cancer cells with quizartinib inhibits key metabolic pathway, activates macroautophagy

Scientists closer to understanding how neurons are wired to form circuits in the eye

Scientists elucidate chemical process behind eosinophilic esophagitis

UCSF-led team develops new technique to create tiny models of human tissues

Resverlogix presents new data on RVX-208 orally active BET inhibitor at ESC Congress 2015

Biocompatible scaffold enables beating heart cells to snap together like Velcro

Scientists reveal role of dynamin and show how specific mutations impair function of dynamin

Can-Fite BioPharma announces Q2 financial results for 2015, updates drug development programs

Findings reveal a new way to prevent meningitis

AMCP issues statement in response to FDA’s draft guidance requiring nonproprietary names for biological products

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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