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Combining chemotherapy and birinapant effective against high-grade serous ovarian cancer

High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but why it so frequently comes back after treatment has been a medical mystery.

4 Aug 2015

BUSM researchers find new way to detect and treat basal-like breast cancer

A new way to detect - and perhaps treat - one of the deadliest types of breast cancer has been found. Led by researchers at Boston University School of Medicine (BUSM), the study appears online in Breast Cancer Research.

3 Aug 2015

Childhood cancer cells produce molecule that affects body's immune system to fight disease

Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body's immune cells, leaving them too physically drained to fight the disease, according to new research published in the journal Cancer Research today (Saturday).

3 Aug 2015

FDA accepts Mundipharma EDO's Investigational New Drug Application for EDO-S101

Mundipharma EDO GmbH (Early Development in Oncology) is pleased to announce that the United States Food and Drug Administration has accepted the company's Investigational New Drug Application ("IND") for EDO-S101, a fusion molecule to treat relapsed/refractory haematologic malignancies and solid tumours.

31 Jul 2015

Scientists chemically synthesize ECA-derived oligosaccharides relevant for immunotherapy

Immunotherapy using monoclonal antibodies is a promising treatment strategy, and it might now be within reach: American scientists have successfully prepared an oligosaccharide enterobacterial antigen for which a monoclonal antibody has been developed. The study is published in the journal Angewandte Chemie.

31 Jul 2015

New chemical reaction breaks strongest bond in molecules instead of weakest

Researchers at Princeton have developed a new chemical reaction that breaks the strongest bond in a molecule instead of the weakest, completely reversing the norm for reactions in which bonds are evenly split to form reactive intermediates.

30 Jul 2015

UIC, Northwestern University researchers create first artificial ribosome

Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell. The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.

30 Jul 2015

Aeterna Zentaris selects optimized Erk inhibitor molecule for further development

Aeterna Zentaris Inc. today announced it has selected an optimized Erk inhibitor molecule for development, thus achieving another important milestone in the development of a new class of potential cancer therapies.

29 Jul 2015

World Health Organization recognizes unique pharmacological nature of Can-Fite's CF101, grants new generic name

Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs that address inflammatory and cancer diseases, today announced that the World Health Organization's International Nonproprietary Name group has accepted the proposed generic name "piclidenoson" for its lead drug candidate, CF101.

29 Jul 2015

Radiation from solar events too weak to cause birth defects down on Earth's surface

Studies find airplane crews at high altitude are exposed to potentially harmful levels of radiation from cosmic rays.

29 Jul 2015

Researchers establish safety, dosing of new drug for treating blood cancers

Researchers at University of California, San Diego School of Medicine have established the safety and dosing of a new drug for treating blood cancers. The findings are published online July 27 in The Lancet Haematology.

29 Jul 2015

TSRI scientists awarded grant to explore therapeutic potential of protein receptors in Parkinson's disease, other disorders

Scientists from the Florida campus of The Scripps Research Institute have been awarded nearly $1.5 million from the National Institute of General Medical Sciences of the National Institutes of Health to explore the therapeutic potential of a class of proteins that play essential roles in the regulation and maintenance of human health.

28 Jul 2015

Regeneron, Sanofi to jointly advance new immuno-oncology treatment options for cancer patients

Regeneron Pharmaceuticals, Inc. and Sanofi have entered into a new global collaboration to discover, develop and commercialize new antibody cancer treatments in the emerging field of immuno-oncology.

28 Jul 2015

Low-dose lithium lowers involuntary motor movements in mouse model of Parkinson's disease

Low-dose lithium reduced involuntary motor movements - the troubling side effect of the medication most commonly used to treat Parkinson's disease (PD) - in a mouse model of the condition that is diagnosed in about 60,000 Americans each year. The third in a series of studies from the Andersen lab involving PD and low-dose lithium, the results add to mounting evidence that low-doses of the psychotropic drug could benefit patients suffering from the incurable, degenerative condition.

28 Jul 2015

Scientists develop exercise mimic molecule that could help treat type 2 diabetes and obesity

Scientists from the University of Southampton have developed a molecule that acts as an exercise mimic, which could potentially help treat type 2 diabetes and obesity.

28 Jul 2015

Simple and accurate detection system can redefine medical diagnostics field

In biology and medicine, we often need to detect biological molecules. For example, in cancer diagnostics, doctors need quick and reliable ways of knowing if tumor cells are present in the patient's body.

25 Jul 2015

Researchers decode molecular mechanism of fish toxin that has potential to treat cancer

Pathogenic bacteria develop killer machines that work very specifically and highly efficiently. Scientists from the University of Freiburg have solved the molecular mechanism of a fish toxin that could be used in the future as a medication to treat cancer. The scientists have now published their research in the journal Nature Communications.

25 Jul 2015

New study reveals protein's critical role in development and progression of AML

A new study by researchers at University of California, San Diego School of Medicine reveals a protein's critical - and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer.

24 Jul 2015

Case Western cancer researchers develop algorithm to detect DNA copy-number alterations in tumors

An algorithm dubbed ENVE could be the Google for genetic aberrations — and it comes from Case Western Reserve.

24 Jul 2015

3SBio purchases entire equity interest in Zhejiang Wansheng

3SBio Inc., a leading China-based biotechnology company focused on researching, developing, manufacturing and marketing biopharmaceutical products, today announced that it has acquired the entire equity interest in Zhejiang Wansheng Pharmaceutical Co., Ltd a limited liability company incorporated in the PRC for an aggregate consideration of RMB 528 million.

24 Jul 2015

Molecule News and Research

Combining chemotherapy and birinapant effective against high-grade serous ovarian cancer

BUSM researchers find new way to detect and treat basal-like breast cancer

Childhood cancer cells produce molecule that affects body's immune system to fight disease

FDA accepts Mundipharma EDO's Investigational New Drug Application for EDO-S101

Scientists chemically synthesize ECA-derived oligosaccharides relevant for immunotherapy

New chemical reaction breaks strongest bond in molecules instead of weakest

UIC, Northwestern University researchers create first artificial ribosome

Aeterna Zentaris selects optimized Erk inhibitor molecule for further development

World Health Organization recognizes unique pharmacological nature of Can-Fite's CF101, grants new generic name

Radiation from solar events too weak to cause birth defects down on Earth's surface

Researchers establish safety, dosing of new drug for treating blood cancers

TSRI scientists awarded grant to explore therapeutic potential of protein receptors in Parkinson's disease, other disorders

Regeneron, Sanofi to jointly advance new immuno-oncology treatment options for cancer patients

Low-dose lithium lowers involuntary motor movements in mouse model of Parkinson's disease

Scientists develop exercise mimic molecule that could help treat type 2 diabetes and obesity

Simple and accurate detection system can redefine medical diagnostics field

Researchers decode molecular mechanism of fish toxin that has potential to treat cancer

New study reveals protein's critical role in development and progression of AML

Case Western cancer researchers develop algorithm to detect DNA copy-number alterations in tumors

3SBio purchases entire equity interest in Zhejiang Wansheng

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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