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Isis Pharmaceuticals begins ISIS-APOCIIIRx Phase 3 study in FCS patients

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 3 study evaluating ISIS-APOCIIIRx in patients with familial chylomicronemia syndrome (FCS). FCS is a rare orphan disease, characterized by extremely high triglyceride levels, that affects an estimated 3,000 to 5,000 patients worldwide.

28 Aug 2014

First Edition: August 28, 2014

Today's headlines include reports about the Congressional Budget Office's latest projections regarding Medicare and Medicaid spending.

28 Aug 2014

Study: Many HIV infected African-Americans may not be receiving effective doses of maraviroc drug

Many African-Americans may not be getting effective doses of the HIV drug maraviroc, a new study from Johns Hopkins suggests. The initial dosing studies, completed before the drug was licensed in 2007, included mostly European-Americans, who generally lack a protein that is key to removing maraviroc from the body.

28 Aug 2014

UW researchers develop smartphone app that detects newborn jaundice within minutes

University of Washington engineers and physicians have developed a smartphone application that checks for jaundice in newborns and can deliver results to parents and pediatricians within minutes. It could serve as a screening tool to determine whether a baby needs a blood test - the gold standard for detecting high levels of bilirubin.

28 Aug 2014

Versatile nanoparticles offer wide variety of diagnostic and therapeutic applications

Kit Lam and colleagues from UC Davis and other institutions have created dynamic nanoparticles (NPs) that could provide an arsenal of applications to diagnose and treat cancer.

27 Aug 2014

Scientists identify number of compounds to treat cancer could add to anti-malarial arsenal

Scientists searching for new drugs to fight malaria have identified a number of compounds -- some of which are currently in clinical trials to treat cancer -- that could add to the anti-malarial arsenal.

26 Aug 2014

Acromegaly and antisense therapy: an interview with Mark Diamond, CEO Antisense Therapeutics

Acromegaly is a chronic, life-threatening disease triggered by a benign tumour of the pituitary gland causing excessive growth hormone release. Oversupply of growth hormone stimulates liver, fat and kidney cells to produce excess levels of Insulin-Like Growth Factor I (IGFI), which causes abnormal growth of the bones of the hands, face and feet and bodily organs.

26 Aug 2014

UT Southwestern researchers discover crucial link between high insulin levels and obesity pathways

UT Southwestern Medical Center researchers have identified a crucial link between high levels of insulin and pathways that lead to obesity, a finding that may have important implications when treating diabetes.

26 Aug 2014

Cancer can be changed from terminal to chronic by cutting liver piece by piece

New surgical methods give hope to patients with cancer that has spread from the intestine to the liver. The disease can be changed from terminal to chronic by cutting the liver piece by piece using keyhole surgery.

25 Aug 2014

Reduce inflammatory reaction by losing weight, says researcher

Researchers have found a possible molecular explanation for why overweight is harmful. This new knowledge may provide new drugs for heart attack, stroke, cancer and chronic intestinal inflammation.

25 Aug 2014

Research shows long non-coding RNAs regulate circadian clocks

Researchers at UT Southwestern Medical Center have found a new way that internal body clocks are regulated by a type of molecule known as long non-coding RNA.

19 Aug 2014

Mount Sinai researchers receive federal funding to treat HCV in primary care settings

With the number of people with chronic hepatitis C reaching record levels in New York City and the recent availability of more effective treatments, researchers from the Icahn School of Medicine at Mount Sinai recently announced the receipt of $1.9 million in federal funding to increase its capacity to treat HCV in primary care settings.

19 Aug 2014

Research findings call for clinical testing of relevant drugs to prevent NASH

Non-alcoholic fatty liver disease (NAFLD) is a common affliction, affecting almost 30 percent of Americans, with a significant number suffering from its most severe form, called non-alcoholic steatohepatitis or NASH, which can lead to cirrhosis and liver cancer. In recent years, NASH has become the leading cause of liver transplantation.

19 Aug 2014

Scientists create computer algorithm for cell and tissue engineering

In a boon to stem cell research and regenerative medicine, scientists at Boston Children's Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Boston University have created a computer algorithm called CellNet as a "roadmap" for cell and tissue engineering, to ensure that cells engineered in the lab have the same favorable properties as cells in our own bodies.

16 Aug 2014

Cases of Ebola virus in West Africa continue to rise

Since the Ebola virus outbreak was first reported in March there have been nearly 2,000 cases and over 1,000 deaths in Guinea, Liberia, Nigeria, and Sierra Leone. This makes it the most serious Ebola epidemic to date.

15 Aug 2014

Research offers promise for personalized RNA combination therapies to treat lung cancer

Small RNA molecules, including microRNAs (miRNAs) and small interfering RNAs (siRNAs), offer tremendous potential for new therapeutic agents to inhibit cancer cell growth. However, delivering these small RNAs to solid tumors remains a significant challenge, as the RNAs must target the correct cells and avoid being broken down by enzymes in the body.

15 Aug 2014

Overweight and obesity linked to 10 common cancers and over 12 000 cases every year in the UK

A higher body mass index (BMI) increases the risk of developing 10 of the most common cancers, the largest study of its kind on BMI and cancer, involving more than 5 million adults in the UK, published in The Lancet shows.

14 Aug 2014

First Edition: August 14, 2014

Today's headlines include a report about an uptick in VA referrals to private physicians. Kaiser Health News staff writer Julie Appleby reports: "Some hospitals in New York, Florida and Wisconsin are exploring ways to help individuals and families pay their share of the costs of government-subsidized policies purchased though the health law's marketplaces – at least partly to guarantee the hospitals get paid when the consumers seek care.

14 Aug 2014

AEG-1 protein blocks effects of retinoic acid in leukemia and liver cancer

Retinoic acid is a form of vitamin A that is used to treat and help prevent the recurrence of a variety of cancers, but for some patients the drug is not effective.

14 Aug 2014

Injections of anaerobic bacteria can shrink tumors in rats, dogs and human

Deep within most tumors lie areas that remain untouched by chemotherapy and radiation. These troublesome spots lack the blood and oxygen needed for traditional therapies to work, but provide the perfect target for a new cancer treatment using bacteria that thrive in oxygen-poor conditions.

14 Aug 2014

Liver News and Research

Isis Pharmaceuticals begins ISIS-APOCIIIRx Phase 3 study in FCS patients

First Edition: August 28, 2014

Study: Many HIV infected African-Americans may not be receiving effective doses of maraviroc drug

UW researchers develop smartphone app that detects newborn jaundice within minutes

Versatile nanoparticles offer wide variety of diagnostic and therapeutic applications

Scientists identify number of compounds to treat cancer could add to anti-malarial arsenal

Acromegaly and antisense therapy: an interview with Mark Diamond, CEO Antisense Therapeutics

UT Southwestern researchers discover crucial link between high insulin levels and obesity pathways

Cancer can be changed from terminal to chronic by cutting liver piece by piece

Reduce inflammatory reaction by losing weight, says researcher

Research shows long non-coding RNAs regulate circadian clocks

Mount Sinai researchers receive federal funding to treat HCV in primary care settings

Research findings call for clinical testing of relevant drugs to prevent NASH

Scientists create computer algorithm for cell and tissue engineering

Cases of Ebola virus in West Africa continue to rise

Research offers promise for personalized RNA combination therapies to treat lung cancer

Overweight and obesity linked to 10 common cancers and over 12 000 cases every year in the UK

First Edition: August 14, 2014

AEG-1 protein blocks effects of retinoic acid in leukemia and liver cancer

Injections of anaerobic bacteria can shrink tumors in rats, dogs and human

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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