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Leukemia drug could prevent and control growth of colorectal tumours

Scientists from Nanyang Technological University (NTU Singapore) and Sweden's Karolinska Institutet, one of Europe's largest and most prestigious medical universities, have discovered that an existing chemotherapy drug used to treat leukaemia could prevent and control the growth of colorectal tumours.

3 Apr 2015

New enzymatically active, ultrathin pepsin membrane splits proteins, separates products

Novel enzymatically active membranes can complete two steps in one: they can enzymatically split proteins and simultaneously separate the products.

2 Apr 2015

Penn Med's BLINKER Team named one of 16 finalists in NIH 'Follow that Cell Challenge'

James Eberwine, PhD, the Elmer Holmes Bobst Professor of Systems Pharmacology and Experimental Therapeutics, at the Perelman School of Medicine at the University of Pennsylvania, was named one of 16 finalists in the first phase of the Follow that Cell Challenge funded by the National Institutes of Health. The competition was run by crowdsourcing company Innocentive and 687 designated "solvers" entered initially.

2 Apr 2015

Novel molecule inhibits cancer-causing transcription factors

A novel molecule designed by scientists at the University of Massachusetts Medical School and the University of Virginia inhibits progression of a hard-to-treat form of recurring acute myeloid leukemia (AML) in patient tissue.

2 Apr 2015

American scientists develop simple system to detect influenza virus from nasal or throat swabs

Almost every winter sees a new wave of influenza, threatening people by its highly contagious character and severe pathogenesis if those with weak or compromised immune system are infected. But when do sniffing and high temperature only point to a bad cold and when is it real influenza? American scientists have developed a simple system for testing for the influenza virus by just taking nasal or throat swabs and measuring the viral presence amperometrically by assessing the glucose level.

2 Apr 2015

Low doses of imatinib drug can push immune system to combat bacterial infections

Low doses of the anti-cancer drug imatinib can spur the bone marrow to produce more innate immune cells to fight against bacterial infections, Emory researchers have found.

1 Apr 2015

MD Anderson, NanoString Technologies collaborate to accelerate development of 'multi-omic' assays

The University of Texas MD Anderson Cancer Center and NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today announced a multi-year collaboration to accelerate the development and adoption of a new type of assay based on NanoString's nCounter Analysis System.

From NanoString Technologies 1 Apr 2015

Folic acid supplements can improve blood vessel dilation in older adults

Supplemental folic acid can enhance blood vessel dilation in older adults, according to Penn State researchers, suggesting that folic acid supplements may be an inexpensive alternative for helping older adults to increase skin blood flow during heat waves and reduce cardiovascular events.

1 Apr 2015

Worthington introduces new line of Animal/Xeno-Free products for biomedical research at EB 2015

Worthington announced today the introduction of several new grades of Collagenase, recombinant Nucleases DNase I and RNases A, T1 & T2 and Neutral Protease (Dispase). All certified Animal/Xeno-Free (AF) to minimize potential BSE/TSE (prion) and mammalian virus contamination risks associated with bovine and other animal-sourced enzymes for primary and stem cell isolation, bioprocessing and other biopharm related applications.

1 Apr 2015

TSRI scientists uncover unique mechanism of natural product with antimicrobial, anti-cancer effects

Scientists from the Florida campus of The Scripps Research Institute have uncovered the unique mechanism of a powerful natural product with wide-ranging antifungal, antibacterial, anti-malaria and anti-cancer effects.

1 Apr 2015

NIH awards $2.1 million grant to counter antibiotic resistance in Gram-negative bacteria

The National Institutes of Health has awarded Dr. Walter Fast, associate professor of medicinal chemistry at The University of Texas at Austin's College of Pharmacy, a four-year $2.1 million grant to develop small-molecules that counter antibiotic resistance in Gram-negative bacteria. If successful, the research could lead to new drugs for treating bacterial infections that are resistant to most antibiotics.

1 Apr 2015

New study sheds light on natural small molecule with antimicrobial effects

31 Mar 2015

New research reveals how a deadly fungus grows and kills immune cells

New research from the University of Toronto has scientists re-thinking how a lethal fungus grows and kills immune cells. The study hints at a new approach to therapy for Candida albicans, one of the most common causes of bloodstream infections.

31 Mar 2015

Less-toxic drug combined with fasting may kill cancer cells

Fasting in combination with chemotherapy has already been shown to kill cancer cells, but a pair of new studies in mice suggests that a less-toxic class of drugs combined with fasting may kill breast, colorectal and lung cancer cells equally well.

31 Mar 2015

Synageva announces submission of Kanuma application to Cofepris for treatment of LAL Deficiency

Synageva BioPharma Corp., a biopharmaceutical company developing therapeutic products for rare disorders, announced today the submission to the Comisión Federal para la Protección contra Riesgos Sanitarios in Mexico for Kanuma as a treatment for patients with lysosomal acid lipase deficiency (LAL Deficiency), a rare genetic disease with significant morbidity and early mortality.

30 Mar 2015

Synthetic Biologics begins SYN-004 Phase 2a clinical trial to prevent C. difficile infection

Synthetic Biologics, Inc., a developer of pathogen-specific therapies for serious infections and diseases, with a focus on protecting the microbiome, today announced the initiation of a Phase 2a clinical trial to evaluate the gastrointestinal (GI) antibiotic-degrading effects and the safety of SYN-004, the Company's investigational oral beta-lactamase enzyme designed to protect the microbiome and prevent C. difficile infection (CDI).

30 Mar 2015

MDC scientists find solution to increase efficiency of precise genetic modifications

CRISPR-Cas9 is a powerful new tool for editing the genome. For researchers around the world, the CRISPR-Cas9 technique is an exciting innovation because it is faster and cheaper than previous methods. Now, using a molecular trick, Dr. Van Trung Chu and Professor Klaus Rajewsky of the Max Delbrück Center for Molecular Medicine Berlin-Buch and Dr. Ralf Kühn, MDC and Berlin Institute of Health, have found a solution to considerably increase the efficiency of precise genetic modifications by up to eightfold.

30 Mar 2015

Genes crucial for vision multiplied in early stages of vertebrate evolution

A new study from SciLifeLab at Uppsala University published in PLOS ONE shows that genes crucial for vision were multiplied in the early stages of vertebrate evolution and acquired distinct functions leading to the sophisticated mechanisms of vertebrate eyes.

30 Mar 2015

Experimental nanoparticle therapy speeds healing of all sorts of wounds

An experimental therapy developed by researchers at Albert Einstein College of Medicine of Yeshiva University cut in half the time it takes to heal wounds compared to no treatment at all. Details of the therapy, which was successfully tested in mice, were published online in the Journal of Investigative Dermatology.

30 Mar 2015

AACR to honor Lewis C. Cantley with Princess Takamatsu Memorial Lectureship

The American Association for Cancer Research will honor Lewis C. Cantley, PhD, with the ninth annual Princess Takamatsu Memorial Lectureship at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

29 Mar 2015

Enzyme News and Research

Leukemia drug could prevent and control growth of colorectal tumours

New enzymatically active, ultrathin pepsin membrane splits proteins, separates products

Penn Med's BLINKER Team named one of 16 finalists in NIH 'Follow that Cell Challenge'

Novel molecule inhibits cancer-causing transcription factors

American scientists develop simple system to detect influenza virus from nasal or throat swabs

Low doses of imatinib drug can push immune system to combat bacterial infections

MD Anderson, NanoString Technologies collaborate to accelerate development of 'multi-omic' assays

Folic acid supplements can improve blood vessel dilation in older adults

Worthington introduces new line of Animal/Xeno-Free products for biomedical research at EB 2015

TSRI scientists uncover unique mechanism of natural product with antimicrobial, anti-cancer effects

NIH awards $2.1 million grant to counter antibiotic resistance in Gram-negative bacteria

New study sheds light on natural small molecule with antimicrobial effects

New research reveals how a deadly fungus grows and kills immune cells

Less-toxic drug combined with fasting may kill cancer cells

Synageva announces submission of Kanuma application to Cofepris for treatment of LAL Deficiency

Synthetic Biologics begins SYN-004 Phase 2a clinical trial to prevent C. difficile infection

MDC scientists find solution to increase efficiency of precise genetic modifications

Genes crucial for vision multiplied in early stages of vertebrate evolution

Experimental nanoparticle therapy speeds healing of all sorts of wounds

AACR to honor Lewis C. Cantley with Princess Takamatsu Memorial Lectureship

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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