Kidney News and Research

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Quercetin and ferulic acid antioxidants aggravate kidney cancer in severely diabetic rats

Scientists are calling for more research on the possibility that some supposedly healthful plant-based antioxidants - including those renowned for their apparent ability to prevent cancer - may actually aggravate or even cause cancer in some individuals. Their recommendation follows a study in which two such antioxidants - quercetin and ferulic acid - appeared to aggravate kidney cancer in severely diabetic laboratory rats. The study appears in ACS' bi-weekly Journal of Agricultural and Food Chemistry.

9 Sep 2010

Johns Hopkins Children's Center urges new screening program to improve sickle cell trait

The Johns Hopkins Children's Center top pediatrician is urging a "rethink" of a new sickle cell screening program, calling it an enlightened but somewhat rushed step toward improving the health of young people who carry the sickle cell mutation.

9 Sep 2010

Researchers demonstrate how insulin prepares cells for glucose uptake

Using high-resolution microscopy, researchers at the National Institutes of Health have shown how insulin prompts fat cells to take in glucose in a rat model. The findings were reported in the Sept. 8 issue of the journal Cell Metabolism.

9 Sep 2010

Jennerex, Transgene enter partnership to develop JX-594 product for tumor treatment

Jennerex, Inc., a private clinical-stage biotherapeutics company focused on the development and commercialization of first-in-class targeted oncolytic products for cancer, and Transgene Euronext, a bio-pharmaceutical company specialized in the development of immunotherapeutic products, today announced that they have entered into an exclusive partnership to develop and commercialize JX-594 for the treatment of solid tumors in Europe, the Commonwealth of Independent States (CIS) and the Middle East.

8 Sep 2010

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they slow tumor growth. Now, researchers in the Developmental Therapeutics Program at Fox Chase Cancer Center have identified an activation signal for AurA. They report in the September 7 issue of Nature Communications that a quick increase in the calcium concentration in a cell rapidly triggers AurA kinase activity.

8 Sep 2010

Promedior initiates PRM-151 Phase 2a clinical study in prevention of scarring post glaucoma filtration surgery

Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic and inflammatory diseases, announced today that it has initiated a Phase 2a clinical study of PRM-151 to evaluate the efficacy, safety, and tolerability of PRM-151 in preventing post-surgical scarring in glaucoma patients following glaucoma filtration surgery. There currently are no approved drugs for preventing post-surgical scarring in glaucoma, and there are no approved anti-fibrotic drug therapies in the U.S. or Europe for any fibrotic disease.

7 Sep 2010

Risk of late onset TRAS in living unrelated donor kidney recipients

Patients who have received a new kidney are significantly more likely to develop transplant renal artery stenosis (TRAS) if they are obese or over 50, according to research published in the September issue of the Journal of Renal Care.

7 Sep 2010

Genetic predisposition reduces breast, ovarian cancer risk with preventive surgeries: Study

A long-term study of women with a genetic predisposition for breast or ovarian cancer showed that those who elected major preventive surgeries had a significantly reduced risk of those cancers.

4 Sep 2010

Fibrosis with inflammation after one year predicts risk of long-term kidney transplant failure

Kidney transplants that show a combination of fibrosis (scarring) and inflammation after one year are at higher risk of long-term transplant failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

3 Sep 2010

Study establishes critical roles for cancer-causing Myc gene in stem cell biology

Stem cells might be thought of as trunks in the tree of life. All multi-cellular organisms have them, and they can turn into a dazzling variety other cells-kidney, brain, heart or skin, for example. One class, pluripotent stem cells, has the capacity to turn into virtually any cell type in the body, making them a focal point in the development of cell therapies, the conquering of age-old diseases or even regrowing defective body parts.

3 Sep 2010

Researchers identify two proteins in cellular response to mechanical stimulation

Scripps Research Institute scientists have identified two proteins with potential to be important targets for research into a wide range of health problems, including pain, deafness, and cardiac and kidney dysfunction.

3 Sep 2010

Study reveals factors linked to cognitive impairment in Type 2 diabetes

Older adults with diabetes who have high blood pressure, walk slowly or lose their balance, or believe they're in bad health, are significantly more likely to have weaker memory and slower, more rigid cognitive processing than those without these problems, according to a new study published by the American Psychological Association.

3 Sep 2010

Researchers unveil prototype model of first implantable artificial kidney

UCSF researchers today unveiled a prototype model of the first implantable artificial kidney, in a development that one day could eliminate the need for dialysis.

3 Sep 2010

Blood pressure treatment may prevent end-stage kidney disease in some patients: Study

Intensively treating hypertension in some African Americans with kidney disease by pushing blood pressure well below the current recommended goal may significantly decrease the number who lose kidney function and require dialysis, suggests a Johns Hopkins-led study publishing in the New England Journal of Medicine Thursday.

2 Sep 2010

Beaumont Hospital expands new multi-organ transplant program

Beaumont Hospital, Royal Oak became Michigan's third liver transplant center on Aug. 31. A 59-year-old man from Royal Oak was the first patient to receive a liver transplant through Beaumont's new multi-organ transplant program.

2 Sep 2010

Illinois profs receive grant to work with kidney dialysis patients

University of Illinois scientists will learn whether protein supplements and cycling during treatments can help dialysis patients fight cardiovascular disease and retain physical function, thanks to a $2.1 million grant from the National Institutes of Health (NIH).

2 Sep 2010

Study on kidneys may help to treat high blood pressure

A study of the body system that deals with Americans' love affair with salt may yield more insight into why so many end up hypertensive and how to better treat them.

2 Sep 2010

Non-kidney transplant patients likely to undergo kidney transplant prior to dialysis: Study

Kidney failure may accompany or complicate transplantation of the liver, heart, or lung. Because increasing numbers of individuals are receiving non-kidney transplants, researchers have wondered whether more of such patients are being listed for kidney transplants.

2 Sep 2010

High vitamin D level improves survival rate in heart failure patients: Study

Survival rates in heart failure patients with reduced levels of vitamin D are lower than in patients with normal levels. This is the finding of a major study carried out at University Medical Center, Groningen, Netherlands. Results also suggest that low levels of vitamin D are associated with activation of the Renin Angiotensin System (RAS - a pivotal regulatory system in heart failure) and an altered cytokine profile.

2 Sep 2010

Michigan, New York roll out high-risk pools

In Michigan, enrollment begins today and is open to adults 19 to 64, the Detroit Free Press reports. The pool "will provide comprehensive but not necessarily cheap coverage for people who can prove they have been denied health insurance in the past six months" and is "intended for any uninsured people in the last six months and who had been turned down by an insurer because of a pre-existing health problem.

2 Sep 2010

Kidney News and Research

Quercetin and ferulic acid antioxidants aggravate kidney cancer in severely diabetic rats

Johns Hopkins Children's Center urges new screening program to improve sickle cell trait

Researchers demonstrate how insulin prepares cells for glucose uptake

Jennerex, Transgene enter partnership to develop JX-594 product for tumor treatment

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

Promedior initiates PRM-151 Phase 2a clinical study in prevention of scarring post glaucoma filtration surgery

Risk of late onset TRAS in living unrelated donor kidney recipients

Genetic predisposition reduces breast, ovarian cancer risk with preventive surgeries: Study

Fibrosis with inflammation after one year predicts risk of long-term kidney transplant failure

Study establishes critical roles for cancer-causing Myc gene in stem cell biology

Researchers identify two proteins in cellular response to mechanical stimulation

Study reveals factors linked to cognitive impairment in Type 2 diabetes

Researchers unveil prototype model of first implantable artificial kidney

Blood pressure treatment may prevent end-stage kidney disease in some patients: Study

Beaumont Hospital expands new multi-organ transplant program

Illinois profs receive grant to work with kidney dialysis patients

Study on kidneys may help to treat high blood pressure

Non-kidney transplant patients likely to undergo kidney transplant prior to dialysis: Study

High vitamin D level improves survival rate in heart failure patients: Study

Michigan, New York roll out high-risk pools

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